Malignant granular cell tumor: case report with a novel karyotype and review of the literature. Ann Diagn Pathol

Department of Pathology, St John Hospital and Medical Center, Detroit, MI 48236, USA.
Annals of diagnostic pathology (Impact Factor: 1.12). 08/2010; 14(4):273-8. DOI: 10.1016/j.anndiagpath.2009.08.004
Source: PubMed


Malignant granular cell tumor is a rare neoplasm reported to occur at various sites in the body. Histogenesis of these tumors is still vaguely understood; however, their metastatic potential and adverse prognosis is well-described in the literature. The histologic criteria of malignancy proposed by Fanburg-Smith et al are still debatable amongst pathologists, with metastasis being the sole criterion of malignancy with unanimous agreement. To our knowledge, no specific karyotype characterizes these tumors. Hence, the importance of detecting characteristic cytogenetic alterations in these tumors which might serve, in the future, as a possible aid in diagnosis or therapy. We report a new case of malignant granular cell tumor of the thigh with metastases to abdominal wall and both lungs causing severe dyspnea. Cytogenetic analysis demonstrated that 60% of cultured tumor cells display the following karyotype 46,XX,+X,dic(5;15).

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    • "p53 expression has been described in neoplastic cells of MGCTs with a variable frequency, ranging from 5% to 100% [15] [16] [22] [23]. Ki-67 proliferating index ranged from 10% to 50% [16] [19] [21] [23]. Le et al. reported that there was not any significant difference between benign and atypical cases' Ki-67 expression [19]. "
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    ABSTRACT: Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the true nature of the lesion. GCT is most commonly solitary but in about 10% of cases can be multifocal, usually involving various skin and soft tissue sites versus involving various internal sites. Therefore, these can involve skin and soft tissue or submucosa and viscera. GCT is usually benign; however, local recurrence is common due to incomplete removal. Malignant cases are rarely reported in 1-2% of cases. In this study, we report clinical and histopathological findings of a 36-year-old woman with metachronous GCT in breast and scalp. The clinical features raise the question of whether these are metachronous benign GCTs or whether this is establishment of malignant behavior. The aim of this report is to present the histopathological and clinical features of GCT and the diagnostic challenge of differentiating benign from malignant GCT.
    Full-text · Article · Jan 2016
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    • "A partial abruptio placenta was noted.28 Malignant granular cell tumor is a rare neoplasm reported to occur at various sites in the body.29 Granular Cell Tumors are rare mesenchymal soft tissue tumors that arise throughout the body and are believed to be of neural origin. "
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    ABSTRACT: Cancer complicates approximately 0.1% of all pregnancies. Primary tracheal carcinoma is one of very rarely seen tumors and the rate of its being seen makes up approximately % 0.2 of all tumors of respiratory tract. The patient, 28 years old, who has 28-weeks-pregnant, was diagnosed with primary tracheal adenocystic carcinoma. Patient was made operation as thoracotomy and tracheal tumor was removed at the 28(th) week of pregnancy. Patient was delivered with sectio abdominale at the 39(th) week of pregnancy. Primary tracheal adenocystic carcinoma is very rarely seen tumors and it is the first tracheal ACC with pregnancy case in literature to have been detected and surgically treated during pregnancy. We discussed primary tracheal adenocystic carcinoma and tracheal tumors during pregnancy with literature.
    Full-text · Article · Jul 2011 · Rare tumors
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    • "Recently, many studies on GCTs have mainly focused on the recognition and correct preoperative diagnosis of this tumor in clinical practice, and on determining the histogenesis of this tumor by performing immunohistochemical, ultrastructural studies and cytogenetic analysis, but not on the management and clinical behavior of the tumor [9]. "
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    ABSTRACT: Granular cell tumor (GCT) is a rare tumor that originates from the Schwann cells in the skin, soft tissues, and internal organs. Usually, GCTs are clinically benign, although malignant and multifocal forms are very rarely known to occur. Cases of GCT of the perianus are rare, and thus far, no study has reported synchronous GCTs of the perianus and the chest wall. We report a case of a 31-year-old woman with synchronous GCTs of the perianus and the chest wall to have a mind of consideration of the possibility of GCT in the differential diagnosis of perianal tumor.
    Full-text · Article · Jul 2011
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