Stabilization of Curcumin by Complexation with Divalent Cations in Glycerol/Water System

Université de Toulouse-UMR 1010, Laboratoire de Chimie Agro-Industrielle, ENSIACET, INPT, INRA, 4 allée Emile Monso, 31432 Toulouse Cedex 4, France.
Bioinorganic Chemistry and Applications (Impact Factor: 1.66). 06/2010; 2010(4):292760. DOI: 10.1155/2010/292760
Source: PubMed


The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn(2+), Cu(2+), Mg(2+), Se(2+)), in "green media" and evaluate its stability in vitro compared to curcumin alone. The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent. Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively. On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

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Available from: Virginie Noirot, Jun 10, 2015
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Questions & Answers about this publication

  • Xabier Vázquez Campos added an answer in Curcumin:
    Why does curcumin have a red color in the alkaline condition?

    Curcumin is soluble in alkaline water. What is the main reason for the red color in alkaline condition?

    Xabier Vázquez Campos

    Because it is solubilized. At neutral or acidic pH is not soluble. Alkaline conditions cause the deprotonation of some of the functional groups making the molecule "more polar". It makes sense giving the pKa values (pKa1, pKa2, and pKa3 value of 7.8, 8.5, and 9.0, respectively, for three acidic protons, see the publication below).

    The color is frequently derived from alternating single and multiple bonds. The color change in alkaline conditions could be a derived effect from the deprotonation or due to complexation (check the patent linked)

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