Nonprogressive and Progressive Primate Immunodeficiency Lentivirus Infections

Immunopathogenesis Unit, Lab of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Immunity (Impact Factor: 21.56). 06/2010; 32(6):737-42. DOI: 10.1016/j.immuni.2010.06.004
Source: PubMed


Natural hosts for simian immunodeficiency virus (SIV) can be, and are often naturally, infected with species-specific SIVs, but do not develop acquired immunodeficiency syndrome (AIDS). These natural hosts maintain high SIV viral loads, but avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to coexist with SIV without overt disease may provide crucial information for understanding AIDS pathogenesis. Over the past few years, several key features of natural SIV infections have been described in studies conducted predominantly in sooty mangabeys (SMs), African green monkeys (AGMs), and mandrills. Natural SIV hosts are able to avoid the chronic, generalized immune system activation that is associated with disease progression in HIV-infected individuals and are known to downmodulate the expression of the receptors for SIV. In this perspective we propose that a critical factor that differentiates nonprogressive from progressive HIV or SIV infection is the maintenance of T cell immune competence in the face of a virus that infects and kills CD4(+) T cells. Elucidation of the mechanisms underlying the preservation of immune function during and after the acute phase of natural SIV infection may lead to the design of novel preventive and therapeutic interventions for treatment of chronic HIV infection.

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    • "One important observation in this regard is that there are low levels of CCR5 coreceptor expression on central memory CD4 T cells in natural SIV hosts[11,29,48].Paiardini et al.demonstrated that central memory CD4 T cells in sooty mangabey resist CCR5 upregulation following activation and were relatively resistant to infection both in vivo and in vitro[49]. Thus, restricted and delayed expression of CCR5 on activated CD4 T cells may preserve the homeostasis of the pool of " resting " naïve and memory CD4 T cells while supporting high levels of virus production in activated effector CD4 cells that are likely to die as a consequence of activation-induced cell death[31]. "
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    ABSTRACT: Simian immunodeficiency virus (SIV)-infected natural hosts do not progress to clinical acquired immune deficiency syndrome yet display high viral replication and an acute immunologic response similar to pathogenic SIV/human immunodeficiency virus infections. During chronic SIV infection, natural hosts suppress their immune activation, whereas pathogenic hosts display a highly activated immune state. Here, we review natural host SIV infections with an emphasis on different immune cell subsets and their potential roles in suppressing immune activation during the chronic phase that contributes to the nonpathogenic outcome of these infections.
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    • "The early dynamics of SIV replication have also been studied in the African green monkeys, mandrills, and sooty mangabeys (Diop et al. 2000; Kornfeld et al. 2005; Onanga et al. 2006). SIV infection in these natural hosts is typically nonpathogenic despite persistent high viral loads (due to robust virus replication), and results in a substantial preservation of the immune system function, lack of chronic immune activation , and a lifespan similar to SIV-uninfected individuals (Brenchley et al. 2010; Paiardini et al. 2009). Interestingly, in both natural and non-natural hosts there is initially a robust innate immune response to the virus. "
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    ABSTRACT: Examining how pathogens cross species boundaries, spread within species, and persist within their hosts is an essential part of understanding the factors that underpin the evolution of virulence and host resistance. Here, we review current knowledge about the genetic diversity, molecular epidemiology, prevalence, and pathogenicity of simian immunodeficiency viruses (SIVs). SIVs have crossed species boundaries from simian hosts to humans on at least 12 separate occasions, one of which led to the global HIV–AIDS crisis. Though SIVs infect a wide range of primates, scientists have only recently begun to describe the natural history of SIV infection in their natural hosts. Several new studies reveal how both viral and host factors are responsible for the transmission to, and adaptation in, new hosts. These studies also suggest that the spread of the virus may be affected by host-specific traits, including social structure, mating system and demographic history. These studies challenge the traditional view that SIV is relatively benign in its natural host, and instead suggest that a highly dynamic relationship exists between SIV and its simian hosts.
    Full-text · Article · Mar 2014 · International Journal of Primatology
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    • "Chronic immune activation is a characteristic feature of HIV-1 infection contributing to CD4+ T cell loss and progression to AIDS and death [1-3]. In contrast, SIV infection of natural primate hosts does not cause chronic immune activation despite sustained systemic viral replication and thus disease progression and immunodeficiency are largely absent [4-6]. Persistent immune activation is characterized by elevated levels of serum cytokines and chemokines [7-9], B cell dysregulation (reviewed in [10]), interference with T cell homeostasis [11,12] and lymphocyte activation, reflected by expression of markers such as CD38 and HLA-DR [3,13], increased in vivo turnover [14,15] and enhanced spontaneous apoptosis [16]. "
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    ABSTRACT: Background HIV infection induces chronic immune activation which is associated with accelerated disease progression; the causes of this activation, however, are incompletely understood. We investigated the activation status of CD4+ T cells specific for chronic herpes viruses and the non-persistent antigen tetanus toxoid (TT) in HIV positive and HIV negative donors to assess whether persistent infections contribute to chronic CD4+ T cell activation. Methods Untreated HIV+ patients and healthy, aged matched controls were recruited and activation levels assessed and compared between cells specific for persistent and non-persistent antigens. Activation levels on antigen-specific CD4+ T cells were measured by intracellular cytokine staining following in vitro stimulation with various recall antigens (CMV, EBV, HSV, VZV and TT) in conjunction with cell surface phenotyping. Results Activation levels of herpes virus-specific CD4+ T cell populations, assessed by co-expression of CD38 and HLA-DR, were significantly elevated in HIV+ individuals compared to normal controls and compared to TT-specific responses. In contrast, we found similar levels of activation of TT-specific CD4+ T cells in HIV+ and HIV- donors. Conclusions These results show a disparate distribution of immune activation within CD4+ T cell populations depending on their specificity and suggest that the elevated level of immune activation that characterizes chronic HIV infection may be influenced by the persistence of other antigens.
    Full-text · Article · Feb 2013 · BMC Infectious Diseases
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