Breast Cancer Chemoprevention: Progress and Controversy

National Surgical Adjuvant Breast and Bowel Project (NSABP), Four Allegheny Center - 5th Floor, Pittsburgh, PA 15212, USA.
Surgical Oncology Clinics of North America (Impact Factor: 1.81). 07/2010; 19(3):463-73. DOI: 10.1016/j.soc.2010.03.005
Source: PubMed


The chemoprevention of breast cancer using pharmacologic agents has had substantial clinical success. Randomized clinical trials evaluating selective estrogen-receptor modulators (SERMs) have shown that these agents reduce the incidence of breast cancer by up to 50% in healthy women at increased risk for the development of the disease. SERMs have been of particular value in women with biopsy-proven risk factors, including atypical hyperplasia or lobular carcinoma in situ of the breast. The agents of established value are important options for women today, and efforts are under way to identify additional more effective therapies.

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    • "Survival rates for breast cancer have greatly increased with significant improvement in surgical technology and therapy regimens over the last three decades, particularly for early-stage breast cancer. However, no effective treatments currently exist for metastatic breast cancer (2,3). As cancer development largely results from the uncontrolled growth of malignant cells, in which cell proliferation surpasses cell death, deregulation of apoptosis, which occurs frequently in a vast majority of cancer types, has become a non-negligible target for anticancer strategies (4,5). "
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