Formulation and Evaluation of Levofloxacin Using Different Types and Concentrations of Superdisintegrants

Journal of Pharmaceutical Sciences and Research 08/2010; 2(5).
Source: DOAJ


Levofloxacin is a fluoroquinolone anti bacterial drug effective in the treatment of bacterial conjunctivitis. Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. The objective of the present work was to comparison of super disintegrants on Levofloxacin oral formulations. Levofloxacin oral formulations were prepared with different concentrations (5%, 10%), of each super disintegrants. The super integrants were sodium starch glycolate (SSG), crosspovidone (XL-10) and crosscarmellose sodium (CCS) usedin the preparation of Levofloxacin oral formulations. The formulations were coded as Lev1 (SSG), Lev2 (Cross povidone) and Lev3 (CCS). The Levofloxacin oral formulation (Lev2) with cross povidone (XL-10) 10% has shown the better disintegration time and increases the dissolution rate when compared to the other super disintegrants.

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