Angiogenesis imaging with vascular-constrained particles: The why and how

ArticleinEuropean Journal of Nuclear Medicine 37 Suppl 1(S1):S114-26 · August 2010with9 Reads
DOI: 10.1007/s00259-010-1502-5 · Source: PubMed
Abstract
Angiogenesis is a keystone in the treatment of cancer and potentially many other diseases. In cancer, first-generation antiangiogenic therapeutic approaches have demonstrated survival benefit in subsets of patients, but their high cost and notable adverse side effect risk have fueled alternative development efforts to personalize patient selection and reduce off-target effects. In parallel, rapid advances in cost-effective genomic profiling and sensitive early detection of high-risk biomarkers for cancer, atherosclerosis, and other angiogenesis-related pathologies will challenge the medical imaging community to identify, characterize, and risk stratify patients early in the natural history of these disease processes. Conventional diagnostic imaging techniques were not intended for such sensitive and specific detection, which has led to the emergence of novel noninvasive biomedical imaging approaches. The overall intent of molecular imaging is to achieve greater quantitative characterization of pathologies based on microanatomical, biochemical, or functional assessments; in many approaches, the capacity to deliver effective therapy, e.g., antiangiogenic therapy, can be combined. Agents with both diagnostic and therapy attributes have acquired the moniker "theranostics." This review will explore biomedical imaging options being pursued to better segment and treat patients with angiogenesis-influenced disease using vascular-constrained contrast platform technologies.
    • "Perfluorocarbon nanoparticles consist of a liquid perfluorocarbon core encapsulated within a monolayer of phospho- lipids123456. The particles are around 250 nm in diameter allowing them to circulate easily through capillary beds. "
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    • "[2] In nanomedicine, the hydrophobic nature of paclitaxel has favored its incorporation into many nanoparticle formulations, including into the phospholipid outer membrane of perfluorocarbon nanoparticles. [3] Perfluorocarbon (PFC) nanoparticles have been targeted to a myriad of epitopes for diagnostic imaging and site-specific drug delivery for applications in atherosclerosis, restenosis, cancer and rheumatoid arthritis.4567 Early comparisons of hydrophobic drugs, including doxorubicin, paclitaxel, and fumagillin , revealed that fumagillin, a potent anti-angiogenic mycotoxin, was retained best in dissolution studies and was effective in vivo. "
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    Full-text · Article · Mar 2014
    • "Numerous studies have demonstrated intensive angiogenesis during the estrous cycle or pregnancy within reproductive tissues including the ovary, uterus and placenta (Reynolds et al., 1992Reynolds et al., , 2000Reynolds et al., , 2002Reynolds et al., , 2005Reynolds et al., , 2006Reynolds et al., , 2010 Redmer, 1995, 2001; Redmer and Reynolds, 1996; Fraser and Lunn, 2000; Jaffe, 2000; Fraser and Wulff, 2001; Grazul-Bilska et al., 2001; Shimizu et al., 2012). Angiogenesis and vascularization have been studied using several methods including (i) in vivo techniques (e.g., perfusion of blood vessels with a fluorescently labeled marker in an entire mouse, imaging of microcirculation with contrast ultrasound , and other imaging techniques (Thurston et al., 1999; Eisenblätter et al., 2010; Kagadis et al., 2010; Kiessling et al., 2010; Lanza et al., 2010; Roesli and Neri, 2010; Seevinck et al., 2010; Gheonea et al., 2011; Sboros et al., 2011; Smith et al., 2011); (ii) in situ techniques (e.g., chicken chorioallantoic membrane [CAM] assay; Redmer et al., 1988; Staton et al., 2009); (iii) in vitro techniques (e.g., migration and proliferation assays; Grazul-Bilska et al., 1995; Auerbach et al., 2003; Staton et al., 2004 Staton et al., , 2009); (iv) histological/immunohistochemical/immunofluorescence techniques (Vonnahme et al., 2006; Grazul-Bilska et al., 2007; Borowicz et al., 2008); (v) molecular biology techniques (Grazul-Bilska et al., 2010) and/or other methods (e.g., vascular casting; Hafez et al., 2010 ). In addition, power and/or color Doppler ultrasonography have been used to study blood flow and vascular tissue perfusion (Rubens et al., 2006; Gebb and Dar, 2011). "
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