Article

Tea and Coffee Consumption and Cardiovascular Morbidity and Mortality

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Arteriosclerosis Thrombosis and Vascular Biology (Impact Factor: 6). 08/2010; 30(8):1665-71. DOI: 10.1161/ATVBAHA.109.201939
Source: PubMed

ABSTRACT

To examine the associations of coffee and tea consumption with risk of morbidity and mortality of stroke and coronary heart disease (CHD) and with all-cause mortality.
Coffee and tea consumption were assessed with a validated food-frequency questionnaire, and 37 514 participants were observed for 13 years for the occurrence of cardiovascular morbidity and mortality. A U-shaped association between coffee and CHD was found, with the lowest hazard ratio (HR [95% CI]) for 2.1 to 3.0 cups per day (0.79 [0.65 to 0.96]; P(trend)=0.01). Tea was inversely associated with CHD, with the lowest HR (95% CI) for more than 6.0 cups per day (0.64 [0.46 to 0.90]; P(trend)=0.02). No associations between tea or coffee and stroke were found (P(trend)=0.63 and P(trend)=0.32, respectively). Although not significant, coffee slightly reduced the risk for CHD mortality (HR, 0.64; 95% CI, 0.37 to 1.11; P(trend)=0.12) for 3.1 to 6.0 cups per day. A U-shaped association between tea and CHD mortality was observed, with an HR of 0.55 (95% CI, 0.31 to 0.97; P(trend)=0.03) for 3.1 to 6.0 cups per day. Neither coffee nor tea was associated with stroke (P(trend)=0.22 and P(trend)=0.74, respectively) and all-cause mortality (P(trend)=0.33 and P(trend)=0.43, respectively).
High tea consumption is associated with a reduced risk of CHD mortality. Our results suggest a slight risk reduction for CHD mortality with moderate coffee consumption and strengthen the evidence on the lower risk of CHD with coffee and tea consumption.

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    • "Case-control and cohort studies have brought inconsistent results. The former have mostly demonstrated an increased risk of cardiovascular diseases (CVD) among regular coffee consumers [Kawachi et al., 1994; Riksen et al., 2009; Sofi et al., 2007], whereas the latter have found no evidence of a detrimental effect of coffee [Higdon & Frei, 2006; Lopez-Garcia et al., 2011; Silletta & Marchioli, 2008], and reported a lower risk of coronary heart disease to be correlated with coffee consumption [de Koning et al., 2010; Kleemola et al., 2000; Woodward & Tunstall-Pedoe, 1999]. Numerous studies conducted by Lopez Garcia et al. have provided strong evidence against the hypothesis that coffee consumption increases the risk of cardiovascular dis- eases [Lopez-Garcia et al., 2006. "
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    • "Epidemiologic studies have indicated that regular coffee consumption is associated with a lower risk for CVD [3] [12] [13]. However, the coffee compounds responsible for the suggestive TAFC contributed to the study design, data collection, analysis, and interpretation , and wrote the manuscript. "
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    • "Several epidemiological and experimental investigations have described an inverse association between tea consumption and cardiovascular diseases [1]. A recent study described an association between coffee and tea consumption and a low morbidity and mortality risk from stroke, coronary heart disease (CHD), and all causes of mortality in 37,514 subjects followed for 13 years [2]. A possible causal factor associated with tea and coffee consumption is the role of bioactive compounds present in these foods in metabolic pathways related to body weight loss, and a consequent reduction of the overall risk for developing metabolic syndrome [3]. "
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