Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

National Cancer Institute, Bethesda, Maryland 20852, USA.
American journal of epidemiology (Impact Factor: 5.23). 07/2010; 172(1):94-106. DOI: 10.1093/aje/kwq121
Source: PubMed


Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are
uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers.
This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort
Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer
cases and 1,066 age-, sex-, race-, and season-of blood draw–matched controls from 8 prospective cohort studies. In multivariate-adjusted
models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by
race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (<25 nmol/L) were associated with a statistically
significant decreased risk of upper GI cancer (reference: 50–<75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31,
0.91; P trend = 0.003). Never smokers with concentrations of <25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55,
95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support
the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers.

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    • "Although a number of studies have investigated associations between serum vitamin D levels and various cancers (Garland and Garland, 1980; Chen et al, 2007; Li et al, 2007; Abbas et al, 2008; Ahn et al, 2008; Abnet et al, 2010; Jenab et al, 2010; Stolzenberg- Solomon et al, 2010), little epidemiologic data for vitamin D and liver cancer are available, despite the important role of the liver in metabolising the circulating form of vitamin D. Supporting a possible association, vitamin D has been shown to inhibit liver carcinogenesis in cell lines and several animal models (Ghous et al, 2008), for example, vitamin D has been shown to reduce the number of chromosomal aberrations and double-strand breaks (Saha et al, 2001) as well as prevent cellular proliferation (Pourgholami et al, 2000; Caputo et al, 2003). For liver disease, results from existing epidemiologic studies, each modest in size, are mixed. "
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    ABSTRACT: C-reactive protein (CRP) is a marker of systemic inflammation that has been associated with the incidence and prognosis for a number of different cancers. Recent data suggest that CRP may be a prognostic factor for liver cancer and cirrhosis. However, few long-term studies are available. We prospectively examined associations between serum CRP and subsequent risk of liver cancer incidence or chronic liver disease mortality in a nested case-control study performed in the Linxian Nutrition Intervention Trials cohort. Baseline serum CRP was measured for 220 incident liver cancer cases, 276 participants who died of chronic liver disease, and 1,018 age-, sex-, and trial-matched controls. Unconditional logistical regression models were used to estimate ORs and 95% confidence intervals (CI). Compared with the lowest quartile, subjects in the fourth quartile of serum CRP had a higher risk of liver cancer incidence (OR, 1.63; 95% CI, 1.06-2.51), with a significant Ptrend across quartiles (P = 0.01). The association with liver cancer was only significant among men (Q4 vs. Q1; OR, 2.00; 1.10-3.62), but not among women (Q4 vs. Q1; OR, 1.15; 0.60-2.22). For chronic liver disease deaths, the corresponding risk estimate in men and women was 2.95 (1.90-4.57), with a monotonic trend (P < 0.001). Higher serum CRP concentrations at baseline were associated with subsequent incidence of liver cancer and death from chronic liver disease. Our findings suggest that levels of systemic inflammation may serve as a long-term marker of liver cancer and liver disease. Cancer Epidemiol Biomarkers Prev; 24(2); 1-7. ©2015 AACR. ©2015 American Association for Cancer Research.
    Full-text · Article · Sep 2013 · British Journal of Cancer
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    • "Upper gastrointestinal (UGI) cancers (gastric and esophagus cancer) constitute a major health problem worldwide (1). Although a decreasing incidence of gastric cancer has been observed during the last decades, it remains the fourth most common cancer worldwide and the second leading cause of cancer-related death (2, 3). "
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    ABSTRACT: The present study aimed to evaluate the prevalence of positive family history of these cancers in a large population-based sample of Tehran province, capital of Iran. Upper gastrointestinal (UGI) cancers (gastric and esophagus cancer) constitute a major health problem worldwide. A family history of cancer can increase the risk for developing cancer and recognized as one of the most important risk factors in predicting personal cancer risk. This study designed as a cross-sectional survey in general population (2006-2007) of Tehran province. Totally 7,300 persons (age > = 20 years) sampled by random sampling on the basis of the list of postal, of whom 6,700 persons agreed to participate (response rate 92%). Respondents were asked if any first-degree (FDR) or second-degree (SDR) relatives had gastric or esophageal cancer. Totally, 6,453 respondents (48% male) entered to the study. The mean age of responders with positive FH was significantly higher than those with negative FH (P < 0.05). In total, 341 respondents (5.3%) reporting a history of UGI cancers in their relatives, 134(2.1%) in FDRs, and 207(3.2%) in SDRs. Our findings showed that the reported prevalence of FH of UGI cancers was relatively low and varied by specific respondent characteristics such as age and sex. However, the estimates of prevalence presented here are likely to be conservative compared with actual prevalence because of self-reported data gathering.
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    • "Results were debatable, and consistent associations have only been demonstrated in colorectal cancer [12,13]. The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers have suggested that circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk, but analysis on race subgroup in that study showed that among Asians, lower concentrations of 25(OH)D were associated with a statistically significant decreased risk of upper GI cancer [14]. A prospective study built an index from factors that predicted higher vitamin D status were statistically significantly associated with a lower risk of esophageal cancer and non-statistically-significantly with a lower risk of stomach cancer [15]. "
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    ABSTRACT: Results from large epidemiologic studies on the association between vitamin D and gastric cancer are controversial. Vitamin D significantly promotes apoptosis in the undifferentiated gastric cancer cell, but the prognostic effects of its levels are unknown. 197 gastric carcinoma patients who received treatment in the cancer centre of Sun Yat-sen University from January 2002 to January 2006 were involved in the study. The stored blood drawn before any treatment was assayed for 25-hydroxyvitamin D levels. The clinicopathologic data were collected to examine the prognostic effects of vitamin D. The mean vitamin D levels of the 197 gastric patients was 49.85 ± 23.68 nmol/L, among whom 114(57.9%) were deficient in Vitamin D(< 50 nmol/L), 67(34%) were insufficient (50-75 nmol/L) and 16(8.1%) were sufficient (> 75 nmol/L). Clinical stage (P = 0.004) and lymph node metastasis classification (P = 0.009) were inversely associated with vitamin D levels. The patients with high vitamin D levels group (≥ 50 nmol/L) had a higher overall survival compared with the low vitamin D levels group (< 50 nmol/L)(P = 0.018). Multivariate analysis indicated that vitamin D levels were an independent prognostic factor of gastric cancer (P = 0.019). Vitamin D deficiency may be associated with poor prognosis in gastric cancer.
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