Disease Genes and Gene Regulation by microRNAs

The John & Jennifer Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, ON, Canada, K1Y 4W7.
Journal of Cardiovascular Translational Research (Impact Factor: 3.02). 06/2010; 3(3):169-72. DOI: 10.1007/s12265-010-9186-6
Source: PubMed

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    ABSTRACT: Aging can be defined as a progressive decline in physiological efficiency regulated by an extremely complex multifactorial process. The genetic makeup of an individual appears to dictate this rate of aging in a species specific manner. For decades now, scientists have tried to look for tiny signatures or signs which might help us predict this rate of aging. MicroRNAs (miRNAs) are a unique class of short, non-coding RNAs that mediate the post-transcriptional regulation of gene expression ranging from developmental processes to disease induction or amelioration. Recently, they have also been implicated to have a role in aging in C.elegans. Based on the fact that there is a considerable similarity between aging in C.elegans and humans, these recent findings might suggest a possible role of miRNAs as bio-markers of aging. This mini-review brushes through the possibilities towards this direction.
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