Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism
Department of Physiology, School of Medicine, Shahed University and Medicinal Plant Research Center, Tehran, Iran. Brain research bulletin
(Impact Factor: 2.72).
07/2010; 82(5-6):279-83. DOI: 10.1016/j.brainresbull.2010.06.004
Parkinson's disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of pelargonidin (Pel) has already been reported, therefore, this study examined whether Pel administration would attenuate behavioural and structural abnormalities and markers of oxidative stress in an experimental model of PD in rat. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA, 12.5mug/5mul of saline-ascorbate)-lesioned rats were pre-treated p.o. with Pel (10 and/or 20mg/kg). Pel administration dose-dependently attenuated the rotational behavior in lesioned rats and protected the neurons of SNC against 6-OHDA toxicity. In addition, pre-treatment with Pel (20mg/kg) significantly decreased the 6-OHDA-induced thiobarbituric acid reactive substances (TBARS) formation, indicative of a neuroprotection against lipid peroxidation. Furthermore, the increase of nitrite levels induced by 6-OHDA, indicate the nitric oxide formation and free radicals production and the decrease of antioxidant defense enzyme superoxide dismutase (SOD) was non-significantly prevented by Pel (20mg/kg). In summary, Pel administration has a dose-dependent neuroprotective effect against 6-OHDA toxicity, partly through attenuating oxidative stress. Our findings suggest that pelargonidin could provide benefits, along with other therapies, in neurodegenerative disorders including PD.
Available from: Behzad Iravani
- "After having the skull drilled carefully, single injection of 0.9 % saline containing 2.5 lg/ll of 6-hy- droxydopamine-HCl (6-OHDA, Sigma) and 0.2 % ascorbic acid (w/v) at a rate of 1 ll/min was injected through a 5 ll Hamilton syringe in anaesthetized rats. The act of injecting performed in a slow rate (1 ll/min) to minimize the possibility of damaging brain tissue . The rats were placed equally in two groups mentioned before. "
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ABSTRACT: Parkinson Disease (PD) is one of the most common neural disorders worldwide. Different treatments such as medication and deep brain stimulation (DBS) have been proposed to minimize and control Parkinson's symptoms. DBS has been recognized as an effective approach to decrease most movement disorders of PD. In this study, a new method is proposed for feature extraction and separation of treated and untreated Parkinsonan rats. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA, 12.5 μg/5 μl of saline-ascorbate)-lesioned rats were treated with DBS. We performed a behavioral experiment and video tracked traveled trajectories of rats. Then, we investigated the effect of deep brain stimulation of subthalamus nucleus on their behavioral movements. Time, frequency and chaotic features of traveled trajectories were extracted. These features provide the ability to quantify the behavioral movements of Parkinsonian rats. The results showed that the traveled trajectories of untreated were more convoluted with the different time/frequency response. Compared to the traditional features used before to quantify the animals' behavior, the new features improved classification accuracy up to 80 % for untreated and treated rats.
Available from: Naila Rasheed
- "Now, connection between DA activity and gastroduodenal ulcer disease is well established  . A number of pharmacological agents have now been designed and tested that showed protective role against brain dysfunctioning  , but whether they have antiulcer activity that remains to be investigated other than our paper . Previously, we have shown that a drug A68930 has antistress activity in acute and chronic unpredictable stress models . "
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ABSTRACT: For decades, it has been suggested that dysfunction of dopaminergic pathways and their associated modulations in dopamine levels play a major role in the pathogenesis of neurological disorders. Dopaminergic system is involved in the stress response, and the neural mechanisms involved in stress are important for current research, but the recent and past data on the stress response by dopaminergic system have received little attention. Therefore, we have discussed these data on the stress response and propose a role for dopamine in coping with stress. In addition, we have also discussed gastric stress ulcers and their correlation with dopaminergic system. Furthermore, we have also highlighted some of the glucocorticoids and dopamine-mediated neurological disorders. Our literature survey suggests that dopaminergic system has received little attention in both clinical and preclinical research on stress, but the current research on this issue will surely identify a better understanding of stressful events and will give better ideas for further efficient antistress treatments.
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ABSTRACT: Aspects of error performance of the land mobile satellite system
(LMSS) using QPSK (quaternary phase-shift keying) and MSK (minimum shift
keying) under fading channel conditions have been studied. In contrast
to the sole use of average bit-error rate (BER) as a performance
measure, bit-by-bit-error rates are calculated for the sequence of
transmitted data under various fading conditions by computer simulation.
For this purpose, various measured data from field experiments are
collected and processed to yield the scaled version of fade amplitudes
and phases for several data transmission cycles. Under the condition of
a moving vehicle at a speed of 55 m.p.h. at 850-MHz transmission, a
series of 256-b data streams at the rate of 2.4 kb/s are simulated using
coherent QPSK and MSK. A total of 203.2 wavelength fade data is used to
give actual fading effects. Results show that bit-by-bit error under
fast varying fade can predict the exact location of error bits among the
sequence of transmitted data, which cannot be done by using average BER
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