Aloe Supplementation for Aging Skin
Vol. 21, No. 1, 2009 11
daily recommended dosage of aloe by the manufacturer of
the study material. From the two doses used in this study,
no dose-response relationship could be demonstrated
clinically (wrinkles and the elasticity measures), biochemi-
cally (procollagen and the MMP-1 gene levels) or micro-
scopically (procollagen staining). Our results indicate no
added advantage of high-dose aloe vera gel ingestion for
cutaneous anti-aging purposes. The limitations of the
study include the lack of a control group. In addition,
daily sunblock use may have added to the protective
effects of aloe; however, sunblock alone does not actively
increase procollagen production or reduce the MMP-1
gene expression. It only renders skin less susceptible to
further photodamage that would occur with the passage of
time. Therefore, the role of sunblock as an active anti-
aging substance could be excluded. For determining the
optimal effective daily dosage of aloe, a placebo-con-
trolled study with a larger number of subjects and a longer
study period is warranted.
Since aloe significantly decreased wrinkles and it
increased elasticity in photoaged human skin in vivo with
an increase of the net procollagen, oral aloe gel sup-
plementation may be a novel anti-aging strategy that
prevents and repairs cutaneous photoaging. A future
challenge will be to determine the mechanism of action of
aloe gel in preventing cutaneous aging.
The authors are indebted to Ae-Kyong Woo and Joo-Mi
Shim for coordinating the study and procuring the cu-
taneous tissues. This research was supported by a grant
from the Korean Food and Drug Administration.
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