Baseline Genotypic and Phenotypic Susceptibilities of HIV-1 Group O to Enfuvirtide

Laboratoire associé au Centre National de Référence du VIH, EA2656, CHU Charles Nicolle, Rouen, France.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.48). 09/2010; 54(9):4016-9. DOI: 10.1128/AAC.00100-10
Source: PubMed


We assessed the natural genotypic and phenotypic susceptibilities to enfuvirtide of 171 HIV group O (HIV-O) samples and 29
strains, respectively. The N42D resistance-associated mutation in the gp41 region was detected in 98% of cases. The phenotypic
assay showed a wide range of baseline susceptibilities, with 50% inhibitory concentrations (IC50s) from 4 to 5,000 nM, a range similar to that reported for HIV-1 group M. Thus, despite the natural genotypic resistance
conferred by the N42D signature mutation, HIV-O variants appear to be phenotypically susceptible. Enfuvirtide could therefore
potentially be used in antiretroviral treatments for HIV-O-infected patients.

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