Article

Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 years

Department of Epidemiology and Social Medicine, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium.
Clinical & Experimental Allergy (Impact Factor: 4.77). 09/2010; 40(9):1378-87. DOI: 10.1111/j.1365-2222.2010.03538.x
Source: PubMed

ABSTRACT

Little data are available on the relationship between indirect antibiotic exposure of the child in utero or during lactation and allergic diseases. On the other hand, several studies have been conducted on the association with direct post-natal antibiotic exposure, but the results are conflicting.
The aim of this study was to investigate pre- and post-natal antibiotic exposure and the subsequent development of eczema, recurrent wheeze and atopic sensitization in children up to the age of 4 years.
We conducted an aetiologic study in 773 children based on a prospective birth cohort project in which environmental and health information were collected using questionnaires. Antibiotic exposure was assessed as maternal antibiotic intake during pregnancy and during lactation and as medication intake of the child. The chronology of exposures and outcomes was taken into account during the data processing. At the age of 1 and 4 years, a blood sample was taken for the quantification of specific IgE.
Prenatal antibiotic exposure was significantly positively associated with eczema, whereas no association was found with recurrent wheeze and atopic sensitization. We found a positive, although statistically not significant, association between antibiotic exposure through breastfeeding and recurrent wheeze. Neither eczema nor atopic sensitization was significantly associated with antibiotic exposure through breastfeeding. Finally, we observed a negative association between the use of antibiotics in the first year of life and eczema and atopic sensitization, and also between antibiotic use after the first year of life and recurrent wheeze, eczema and atopic sensitization.
Indirect exposure to antibiotics (in utero and during lactation) increases the risk for allergic symptoms in children, while direct exposure to antibiotics appears to be protective. The biological mechanisms underlying these findings still need to be elucidated.

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    • "Les mécanismes susceptibles d'expliquer les effets variables du paracétamol sur le risque de DA en fonction du niveau d'exposition précoce des enfants aux antibiotiques et en fonction des autres pathologies allergiques restent à déterminer. Dom et al. [49] ont effectué une étude prospective chez 773 enfants suivis, depuis la grossesse et jusqu'à l'âge de quatre ans, sur la base de l'histoire clinique maternelle et de l'enfant, et des résultats des dosages des IgE sériques spécifiques des trophallergènes et aéro-allergènes courants de l'enfant, dosages effectués aux âges de un et quatre ans. Ont tout particulièrement été étudiées les relations possibles entre l'exposition des enfants à des antibiotiques pendant la grossesse, pendant l'allaitement au sein et pendant le début de la vie, et les risques de sensibilisation allergénique et de développement d'une ou plusieurs maladies de type allergique (DA, wheezing récurrent). "

    Full-text · Dataset · Oct 2014
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    • "Les mécanismes susceptibles d'expliquer les effets variables du paracétamol sur le risque de DA en fonction du niveau d'exposition précoce des enfants aux antibiotiques et en fonction des autres pathologies allergiques restent à déterminer. Dom et al. [49] ont effectué une étude prospective chez 773 enfants suivis, depuis la grossesse et jusqu'à l'âge de quatre ans, sur la base de l'histoire clinique maternelle et de l'enfant, et des résultats des dosages des IgE sériques spécifiques des trophallergènes et aéro-allergènes courants de l'enfant, dosages effectués aux âges de un et quatre ans. Ont tout particulièrement été étudiées les relations possibles entre l'exposition des enfants à des antibiotiques pendant la grossesse, pendant l'allaitement au sein et pendant le début de la vie, et les risques de sensibilisation allergénique et de développement d'une ou plusieurs maladies de type allergique (DA, wheezing récurrent). "
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