"One drug that appears to be effective in this respect is off-label aprepitant, a neurokinin 1 (NK-1) receptor antagonist that was approved in 2003 for the prevention of chemotherapy-induced nausea and vomiting, both acute and delayed. The main ligand of the NK-1 receptor, substance P, has emerged as an important mediator of the induction and maintenance of pruritus
. Furthermore, increased levels of NK-1 have been reported in the keratinocytes of patients with chronic pruritus
[Show abstract][Hide abstract] ABSTRACT: Introduction. Paraneoplastic pruritus is defined as pruritus that occurs before or during the natural evolution of a hematologic disease. The reported prevalence is 30% in patients with Hodgkin's lymphoma. The severity of this pruritus has a very negative impact on patients' quality of life. Very few studies have been made to examine the efficacy of pharmacological treatments for this type of pruritus. One drug that appears to be effective in this respect is off-label aprepitant, a neurokinin 1 receptor antagonist.
Full-text · Article · Sep 2014 · Journal of Medical Case Reports
[Show abstract][Hide abstract] ABSTRACT: A new method of measuring and extracting bias dependent noise
parameters for GaAs MESFETs and PHEMTs is presented. This technique only
requires noise figure and S-parameter measurements over frequency. This
eliminates the need for time-consuming traditional sourcepull
measurements and facilitates rapid noise parameter extraction. This
technique makes the extraction of bias-dependent noise models of MESFETs
and PHEMTs practical, for the first time, in a production test
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