Pancreas transplantation in the United States: an analysis of the UNOS registry.

One Lambda Inc, Canoga Park, California, USA.
Clinical transplants 01/2009;
Source: PubMed


Pancreas transplantation is an important option to those with diabetes. Survival rates and number of pancreas transplants have improved with the advent of newer immunosuppressive agents (tacrolimus and mycophenolate). The median survival for pancreas transplants was approximately 9 years (10 years for SPK recipients). However, at 21-years the survival rate was < 10%. In all, the long-term success of pancreas transplants still has room for improvement. And with a new surge to look for HLA antibodies (8) and potentially to treat or prevent their development, there is hope that survival over the next 20 years will be much improved.

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    ABSTRACT: PURPOSE OF REVIEW: Due to the extreme lack of an international registry of pancreas transplantation, the purpose of this review was to conduct an extensive collection of data on the activity of pancreas transplantation in non-United States areas. RECENT FINDINGS: Over 10 000 pancreas transplants were collected in non-US areas. These countries together account for annual activity of about 1100 pancreas transplants out of which 85% are simultaneous pancreas-kidney transplants. Europe stands with 6766 pancreas transplantation, followed by Latin America with 1945, Canada with 671, Oceania with 499, Asia with 222 and Africa with five. Adding this activity of pancreas transplantation to the US data, we reach the mark of about 32 000 pancreas transplants performed worldwide and the overall activity roughly 'jumps' to approximately 2300 procedures annually. SUMMARY: From the data collected in this article, it is possible to have a current dimension of the pancreas transplantation activity worldwide. This study should serve as a stimulus for the creation of a single international registry and guide future analysis and protocols in the pancreas transplantation field in different continents.
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