Selective Use of Embolic Protection Devices During Saphenous Vein Grafts Interventions: A Single-Center Experience

Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.
Catheterization and Cardiovascular Interventions (Impact Factor: 2.11). 12/2009; 75(7):1037-44. DOI: 10.1002/ccd.22392
Source: PubMed


To report on outcomes with selective use of embolic protection devices (EPD) during percutaneous coronary intervention (PCI) to saphenous vein grafts (SVG).
PCI to SVG is associated with increased risk and the use of EPD is recommended in this setting. Methods: Angiographic and clinical outcomes were prospectively obtained from 534 consecutive patients who underwent PCI to SVG with or without EPD at a tertiary cardiac centre. Long-term outcomes were obtained by linkage to a provincial registry.
EPD, deployed in 198 of 373 SVGs (53%) suitable for deployment of a distal EPD, were used more often in ectatic (33% vs. 19%, P = 0.003), ulcerated (17% vs. 9%, P = 0.03), thrombotic (26% vs. 10%, P < 0.0001) vein grafts, with longer degenerated segments (P = 0.002), and in lesions involving the body of the graft (85% vs. 66%, P < 0.0001), and less with lesions involving the graft ostium (29% vs. 44%, P = 0.003). Patients suitable for but not receiving EPD tended to be more likely to have a periprocedural myocardial infarction. During 3 years of follow-up, 49% of the patients had a cardiovascular event. Cumulative mortality was 8.4%, 18.8% and 14.7% in patients unsuitable for distal EPD, suitable but without EPD, and with EPD (p = 0.11). Nonuse of EPD was an independent predictor of MACE at 3 years. (P = 0.02).
Selective use of EPD is associated with low in-hospital cardiovascular event rates. Long-term outcomes are manifested by a high rate of events, especially in patients with SVG's suitable for but not receiving EPD. This suggests that routine use of distal EPD may be warranted in unselected patients with suitable SVG anatomy.

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Available from: Vladimir Dzavik, Mar 18, 2015
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    • "Some studies had revealed the benefit of the use of EPD in lowering in-hospital cardiovascular event rate and improving long-term outcomes.[8] The AHA/ACC guidelines suggested mandatory use of EPD in SVG graft PCI.[9] "
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