Prevention strategies for herpes zoster and post-herpetic neuralgia

ArticleinJournal of clinical virology: the official publication of the Pan American Society for Clinical Virology 48 Suppl 1:S14-9 · May 2010with12 Reads
Impact Factor: 3.02 · DOI: 10.1016/S1386-6532(10)70004-4 · Source: PubMed


    Impairment of varicella zoster virus (VZV)-specific cell-mediated immunity, including impairment due to immunosenescence, is associated with an increased risk of developing herpes zoster (HZ), whereas levels of anti-VZV antibodies do not correlate with HZ risk. This crucial role of VZV-specific cell-mediated immunity suggests that boosting these responses by vaccination will be an effective strategy for reducing the burden of HZ. Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants, anticonvulsants and analgesics.