Combined Inhibitory Effects of Soy Isoflavones and Curcumin on the Production of Prostate-Specific Antigen

ArticleinThe Prostate 70(10):1127-33 · July 2010with68 Reads
DOI: 10.1002/pros.21147 · Source: PubMed
Abstract
Sustained chronic inflammation in the prostate promotes prostate carcinogenesis. Since an elevated level of prostate-specific antigen (PSA) per se reflects the presence of inflammation in the prostate, intervention to improve the PSA value might potentially have beneficial effects for the prevention of the development of prostate cancer. Isoflavones and curcumin have anti-inflammatory and anti-oxidant properties. We examined the biological effects of soy isoflavones and curcumin on LNCaP cells. After that, we conducted a clinical trial for men who received prostate biopsies, but were not found to have prostate cancer, to evaluate the effects of soy isoflavones and curcumin on serum PSA levels. The expression of androgen receptor and PSA were examined in LNCaP cells before and after treatment of isoflavones and/or curcumin. Eighty-five participants were randomized to take a supplement containing isoflavones and curcumin or placebo daily in a double-blind study. Subjects were subdivided by the cut-off of their baseline PSA value at 10 microg/ml. We evaluated values of PSA before and 6 months after treatment. The production of PSA were markedly decreased by the combined treatment of isoflavones and curcumin in prostate cancer cell line, LNCaP. The expression of the androgen receptor was also suppressed by the treatment. In clinical trials, PSA levels decreased in the patients group with PSA >or= 10 treated with supplement containing isoflavones and curcumin (P = 0.01). Our results indicated that isoflavones and curcumin could modulate serum PSA levels. Curcumin presumably synergizes with isoflavones to suppress PSA production in prostate cells through the anti-androgen effects.
    • "The clinical trials in this section were identified from the PubMed database using the MeSH term " neoplasms " combined with " polyphenols " . [193] 158 men aged 50–75 with rising prostate specific antigen isoflavone (60 mg) daily for 12 months reducing prostate cancer incidence for patients aged 65 or more [194] 86 patients with localized prostate cancer soy isoflavone (80 mg total isoflavones, 51 mg aglucon units) daily for 6 weeks no significant change in serum hormone levels, total cholesterol, or PSA [195] 10 breast cancer patients undergoing radiotherapy EGCG (400 mg) thrice daily for 2–8 weeks enhancing efficacy of radiotherapy [196] [197] 87 patients with resected colorectal cancer or polypectomy flavonoid mixture (20 mg apigenin and 20 mg EGCG) for 3–4 years reducing recurrence rate of colon neoplasia in patients with resected colon cancer [198] 5 familial adenomatous polyposis patients with colectomy curcumin (480 mg) and quercetin (20 mg) thrice daily for 6 months reducing polyp number and size from baseline without appreciable toxicity [199] 85 patients with prostate cancer isoflavones (40 mg) and curcumin (100 mg) daily for 6 months decreasing level of serum PSA [200] 44 smokers with 8 or more aberrant crypt foci curcumin (2 or 4 g) daily for 30 days decreasing number of aberrant crypt foci [201] 126 patients with colorectal cancer curcumin (360 mg) thrice daily for 10–30 days increasing body weight and expression of p53, suppressing serum level of TNF-α [202] "
    [Show abstract] [Hide abstract] ABSTRACT: There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.
    Full-text · Article · Aug 2016
    • "Ide et al., conducted a randomized, double blind study, wherein the efficacy of a combination therapy of soy isoflavones and curcumin was evaluated [309]. Eighty five participants who underwent prostate biopsies because of increased PSA (prostate-specific antigen) levels but had negative prostate cancer findings were enrolled. "
    [Show abstract] [Hide abstract] ABSTRACT: Despite significant advances in treatment modalities over the last decade, neither the incidence of the disease nor the mortality due to cancer has altered in the last thirty years. Available anti-cancer drugs exhibit limited efficacy, associated with severe side effects, and are also expensive. Thus identification of pharmacological agents that do not have these disadvantages is required. Curcumin, a polyphenolic compound derived from turmeric (Curcumin longa), is one such agent that has been extensively studied over the last three to four decades for its potential anti-inflammatory and/or anti-cancer effects. Curcumin has been found to suppress initiation, progression, and metastasis of a variety of tumors. These anti-cancer effects are predominantly mediated through its negative regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other oncogenic molecules. It also abrogates proliferation of cancer cells by arresting them at different phases of the cell cycle and/or by inducing their apoptosis. The current review focuses on the diverse molecular targets modulated by curcumin that contribute to its efficacy against various human cancers.
    Full-text · Article · Feb 2015
    • "Recurrent or chronic inflammation has been implicated in the development of a variety of human can- cers [63,64] . Inflammation promotes cellular proliferation, angiogenesis, inhibits apoptosis, and induces DNA damage, increasing the risk of developing cancer656667 . "
    [Show abstract] [Hide abstract] ABSTRACT: Cruciferous vegetables belong to the plant family that has flowers with four equal-sized petals in the pattern of a crucifer cross. These vegetables are an abundant source of dietary phytochemicals, including glucosinolates and their hydrolysis products such as indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM). By 2013, the total number of natural glucosinolates that have been documented is estimated to be 132. Recently, cruciferous vegetable intake has garnered great interest for its multiple health benefits such as anticancer, antiviral infections, human sex hormone regulation, and its therapeutic and preventive effects on prostate cancer and high grade prostatic intraepithelial neoplasia (HGPIN). DIM is a hydrolysis product of glucosinolates and has been used in various trials. This review is to provide an insight into the latest developments of DIM in treating or preventing both prostate cancer and HGPIN.
    Article · Sep 2014
Show more