Combined Inhibitory Effects of Soy Isoflavones and Curcumin on the Production of Prostate-Specific Antigen

ArticleinThe Prostate 70(10):1127-33 · July 2010with68 Reads
DOI: 10.1002/pros.21147 · Source: PubMed
Sustained chronic inflammation in the prostate promotes prostate carcinogenesis. Since an elevated level of prostate-specific antigen (PSA) per se reflects the presence of inflammation in the prostate, intervention to improve the PSA value might potentially have beneficial effects for the prevention of the development of prostate cancer. Isoflavones and curcumin have anti-inflammatory and anti-oxidant properties. We examined the biological effects of soy isoflavones and curcumin on LNCaP cells. After that, we conducted a clinical trial for men who received prostate biopsies, but were not found to have prostate cancer, to evaluate the effects of soy isoflavones and curcumin on serum PSA levels. The expression of androgen receptor and PSA were examined in LNCaP cells before and after treatment of isoflavones and/or curcumin. Eighty-five participants were randomized to take a supplement containing isoflavones and curcumin or placebo daily in a double-blind study. Subjects were subdivided by the cut-off of their baseline PSA value at 10 microg/ml. We evaluated values of PSA before and 6 months after treatment. The production of PSA were markedly decreased by the combined treatment of isoflavones and curcumin in prostate cancer cell line, LNCaP. The expression of the androgen receptor was also suppressed by the treatment. In clinical trials, PSA levels decreased in the patients group with PSA >or= 10 treated with supplement containing isoflavones and curcumin (P = 0.01). Our results indicated that isoflavones and curcumin could modulate serum PSA levels. Curcumin presumably synergizes with isoflavones to suppress PSA production in prostate cells through the anti-androgen effects.
    • "The clinical trials in this section were identified from the PubMed database using the MeSH term " neoplasms " combined with " polyphenols " . [193] 158 men aged 50–75 with rising prostate specific antigen isoflavone (60 mg) daily for 12 months reducing prostate cancer incidence for patients aged 65 or more [194] 86 patients with localized prostate cancer soy isoflavone (80 mg total isoflavones, 51 mg aglucon units) daily for 6 weeks no significant change in serum hormone levels, total cholesterol, or PSA [195] 10 breast cancer patients undergoing radiotherapy EGCG (400 mg) thrice daily for 2–8 weeks enhancing efficacy of radiotherapy [196] [197] 87 patients with resected colorectal cancer or polypectomy flavonoid mixture (20 mg apigenin and 20 mg EGCG) for 3–4 years reducing recurrence rate of colon neoplasia in patients with resected colon cancer [198] 5 familial adenomatous polyposis patients with colectomy curcumin (480 mg) and quercetin (20 mg) thrice daily for 6 months reducing polyp number and size from baseline without appreciable toxicity [199] 85 patients with prostate cancer isoflavones (40 mg) and curcumin (100 mg) daily for 6 months decreasing level of serum PSA [200] 44 smokers with 8 or more aberrant crypt foci curcumin (2 or 4 g) daily for 30 days decreasing number of aberrant crypt foci [201] 126 patients with colorectal cancer curcumin (360 mg) thrice daily for 10–30 days increasing body weight and expression of p53, suppressing serum level of TNF-α [202] "
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