Article

A family history study of intermittent explosive disorder

Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA. .
Journal of Psychiatric Research (Impact Factor: 3.96). 11/2010; 44(15):1101-5. DOI: 10.1016/j.jpsychires.2010.04.006
Source: PubMed

ABSTRACT

Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial.
Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria.
Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands.
IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions.

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    • "and substance use (35.1–48%) disorders (Kessler et al., 2006; Grant, 2008). A recent family history study found that first-degree relatives of individuals with IED are more likely to have a psychiatric condition compared to control subjects, however specific rates of psychiatric conditions were not reported (Coccaro, 2010). "
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    ABSTRACT: Intermittent explosive disorder is an impulse control disorder characterized by the occurrence of discrete episodes of failure to resist aggressive impulses that result in violent assault or destruction of property. Though the prevalence intermittent explosive disorder has been reported to be relatively rare in frontier studies on the field, it is now common opinion that intermittent explosive disorder is far more common than previously thought especially in clinical psychiatry settings. Etiological studies displayed the role of both psychosocial factors like childhood traumas and biological factors like dysfunctional neurotransmitter systems and genetics. In differential diagnosis of the disorder, disorders involving agression as a symptom such as alcohol and drug intoxication, antisocial and borderline personality disorders, personality changes due to general medical conditions and behavioral disorder should be considered. A combination of pharmacological and psychotherapeutic approaches are suggested in the treatment of the disorder. This article briefly reviews the historical background, diagnostic criteria, epidemiology, etiology and treatment of intermittent explosive disorder.
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    ABSTRACT: Intermittent explosive disorder (IED) is characterized by recurrent episodes of impulsive, uncontrollable aggression out of proportion to the severity of provoking agents. Few epidemiological studies have been carried out on the prevalence and correlates of IED. Data are reported here from the most recent and largest of these studies: the U.S. National Comorbidity Survey Replication (NCS-R) and the World Health Organization World Mental Health (WMH) surveys. These studies show that IED is a commonly occurring disorder that typically has an early age of onset, a persistent course, and strong comorbidity with a number of other usually secondary mental disorders. This disorder is almost twice as common among men as women. It is often associated with substantial distress and impairment. However, only a minority of people with IED obtain treatment for their uncontrollable anger. This combination of features makes IED an ideal target for early detection and intervention aimed at secondary prevention of anger attacks as well as primary prevention of secondary disorders.
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