Ethynyldiisopropylsilyl: A New Alkynylsilane Protecting Group and “Click” Linker

ArticleinOrganic Letters 12(12):2860-3 · June 2010with9 Reads
Impact Factor: 6.36 · DOI: 10.1021/ol100968t · Source: PubMed


    A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group linker.