Article

Anodic voltammetry of zolmitriptan at boron-doped diamond electrode and its analytical applications

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, Ankara, Turkey.
Pharmazie (Impact Factor: 1.05). 04/2010; 65(4):245-50. DOI: 10.1691/ph.2010.9245
Source: PubMed

ABSTRACT

The electrooxidative behavior and determination of zolmitriptan at a boron-doped diamond electrode were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. Zolmitriptan undergoes irreversible oxidation at a peak potential of about +0.9 V (vs Ag/AgCl/3 M KCl). DPV and SWV techniques are proposed for the determination of zolmitriptan in phosphate buffer at pH 3.03, which allows quantitation over the two different ranges (8 x 10(-7) - 8 x 10(-6) M and 1 x 10(-5) - 1 x 10(-4) M) in supporting electrolyte for both methods. A linear response was obtained in phosphate buffer over two different ranges (6 x 10(-7) - 8 x 10(-6) M and 1 x 10(-5) - 1 x 10(-4) M) for spiked serum samples at pH 3.03 for both techniques. The repeatability and reproducibility of the methods for all media were determined. The standard addition method was used in serum. Precision and accuracy were also checked in all media. No electroactive interferences from the excipients and endegenous substances were found in the pharmaceutical dosage form and the biological sample, respectively.

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    • "The assay of ZMT in pure and dosage forms, as far as we know, is not official in any pharmacopoeia, and therefore, requires much more investigation. The different analytical methods that have been reported for its determination include HPLC with mass spectrometry detection [2] [3] [4] [5] [6] [7], with coulometric detection [8], electrospray ionization mass spectrometry [9], tandem mass spectrometry [10], fluorescence detection [11] [12] in pharmaceutical preparations and biological fluids and spectrophotometric and flourometric methods [13] [14] [15] [16] [17] [18] [19] [20]. In the present work, spectroscopic analytical study for the analysis of zolmitriptan in pure and its Syrian pharmaceutical dosage forms through complexation with Sulphonphthalein dyes in dichloromethan medium has been applied . "

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    • "Furthermore, high hardness, high thermal conductivity, and chemical inertness of the electrode [21] offer quick and reliable analysis. BDDE has been successfully applied in the voltammetric analysis of biologically active compounds [9,14,19,222324252627282930313233. The aim of this work was to develop the procedure to determine Fnf on a bare BDDE and methods for its SWV determination in spiked natural river waters and triticale samples. "
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    ABSTRACT: A simple, selective, and sensitive electroanalytical method for the determination of a novel fungicide, fenfuram (Fnf), on a bare boron-doped diamond electrode (BDDE) using square-wave voltammetry (SWV) was developed. For the first time, the electrochemical oxidation of Fnf at BDDE at about 1.5 V vs. Ag/AgCl reference electrode in 0.35 mol L−1 sulfuric acid was investigated. To select the optimum experimental conditions, the effects of the supporting electrolyte, pH, frequency, amplitude, and step potential were studied. The developed method allowed the determination of Fnf in the concentration range of 2.4×10−5 to 2.6×10−4 mol L−1 (LOD = 6.3×10−6 mol L−1, LOQ = 2.1×10−5 mol L−1). The validation of the method was carried out. The proposed procedure was successfully applied to determine Fnf in the spiked natural water samples collected from Polish rivers and in the spiked triticale seed samples by the standard addition method. To understand the Fnf electrode mechanism, the cyclic voltammetry (CV) technique was applied. The oxidation mechanism was also confirmed using mass spectrometry with the electrospray ionization (ESI-MS) technique. Using electrochemical techniques, the effect of Fnf on the corrosion properties of stainless steel which is used to produce agricultural tools was studied.
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    • "Most of the reported methods [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] require expensive instrumental setup, expertise personnel, and complicated procedure. Two of the reported visible spectrophotometric "
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    ABSTRACT: An accurate and precise spectrophotometric method is presented for the determination of zolmitriptan (ZMT) based on the formation of a red color product with vanillin in presence of concentrated H2SO4, with the chromogen being measured at 580 nm. The reaction proceeds quantitatively at room temperature in 10 min. The calibration curve is linear over the range 5.0–90.0 μg mL−1 and described by the regression equation 𝑌 = ( − ) 0 . 0 1 0 1 + 0 . 0 1 1 7 𝑋 with a regression coefficient ( 𝑟 ) of 0.9994 ( 𝑛 = 7 ) . The calculated molar absorptivity and Sandell sensitivity values are 3.3 × 103 L mol−1 cm−1 and 0.0872 μg cm−2, respectively. The limits of detection (LOD) and quantification (LOQ) calculated as per ICH guidelines are 1.26 and 3.81 μg mL−1, respectively. The within-day accuracy expressed as relative error was better than 1.78% with precision (RSD) ranging from 0.83 to 1.45%. The between-day accuracy ranged from 1.21 to 1.84% with a precision less than 1.66%. The method was successfully applied to the analysis of one brand of tablet containing zolmitriptan. The results obtained were in agreement with those obtained by published reference method. The accuracy was also checked by placebo blank and synthetic mixture analyses besides recovery study via standard addition procedure.
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