Biotransformation of mefenamic acid by cell suspension cultures of Solanum mammosum

Natural product communications (Impact Factor: 0.91). 01/2011; 3(2).
Source: OAI


Five biotransformation products, mefenamic acid-7-O-β-D-glucopyranosyl ester (2), mefenamic acid-7-O-β-D-(β-1,6-O-D-glucopyranosyl)- glucopyranosyl ester (3), mefenamic acid-7-O-β-D-(β-1,2-O-D- glucopyranosyl)-glucopyranosyl ester (4), mefenamic acid-7-O-β-D-(β-1, 6-O-D-glucopyranosyl)-2-glucopyranose ester (5), and mefenamic acid-7-O-α-D-(β-1,6-O-D-glucopyranosyl)-2-glucopyranose ester (6) were isolated from cell suspension cultures of Solanum mammosum following administration of the therapeutic agent mefenamic acid (1). The structures of all new compounds were elucidated on the basis of their NMR and mass spectrometric data.

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Available from: Gunawan Indrayanto, Apr 06, 2015
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    ABSTRACT: Plant cell culture is an important approach for the production of secondary metabolites, which can obtain the natural products quickly and efficiently. The different ways and research progresses of producing secondary metabolites via plant cell culture in recent years were reviewed in this paper, from the three aspects of culture methods, culture techniques, biotransformation and genetic engineering. In addition, it was expounded the main types of secondary metabolites and synthetic pathways, and enumerated a large number of application examples and types of secondary metabolites and the corresponding culture conditions. Thence, all of these play a certain role in guiding the quick selection of culture conditions for the purpose of secondary metabolites.
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