Article

BDNF Va166Met polymorphism is associated with aggressive behavior in schizophrenia

IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy.
European Psychiatry (Impact Factor: 3.44). 10/2010; 25(6):311-3. DOI: 10.1016/j.eurpsy.2009.10.008
Source: PubMed

ABSTRACT

Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

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Available from: Gianfranco Spalletta, Dec 16, 2014
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    • "BDNF affects susceptibility to environmental stressors in the prediction of impulsive aggression (Wagner, Baskaya, Dahmen, Lieb, & Tadić, 2010) with met-allele carriers being more vulnerable to environmental risk than valval carriers. Moreover, carriers of the met-allele show an increased risk for psychopathological disorders related to aggression (e.g., Spalletta et al., 2010) and impulsivity (Oades et al., 2008). In line with previous research, Kretschmer et al. (2014) showed a stronger effect of peer on adolescents' own aggression in carriers of the met-met variant of this polymorphism. "

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    • "Aggression in schizophrenia or related psychotic disorders [SRPD] can occur because of a multitude of reasons, varying from positive psychotic symptoms, impulsivity, personality disorders, co-morbid substance use to even depression (Volavka & Citrome, 2008). Various studies have provided useful predictive socio demographic, clinical and genetic risk factors for aggression in schizophrenia (Swanson et al., 2006; Spalletta et al., 2010) but no single variable has been entirely explanatory and hence aggressive behaviour has come to be understood as arising out of an interaction between the patient's psychopathology and unique personal history with the social and cultural system he/she inhabits. "
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    ABSTRACT: Background/Context: There is high risk of violence and aggression in the medical emergency care settings (MECS) of which psychiatric services constitute an important part, forming lateral entry points for patients into the mental health care system. Psychosis has been imposed as the predominant cause for majority of aggressive presentation in MECS. There is scarcity of Indian data towards this facet. Objective(s): The aim of the study is to explore the principal reasons for referral to a psychiatric emergency and explore the disorders most commonly associated with violent and aggressive behavior. Methodology: This cross sectional descriptive study evaluated consecutive psychiatry referrals from the emergency ward for duration of six months at a tertiary care center. Data was gathered using a semi structured proforma and analyzed by SPSS version 17.0. Diagnosis of schizophrenia or related psychotic disorders (SRPD) and other psychiatric disorders was ascertained via ICD-10. Result(s): Majority of the overall emergency psychiatry referrals presented with aggression (42%) with no significant gender difference. About 72% of aggressive subjects were diagnosed with psychiatric disorders, of which 28% suffered from SRPD. Delirium and affective disorders constituted 12% and 16% of the aggressive subjects respectively, while diagnosis could not be ascertained in 28% subjects. Of the 462 referred cases, 13.6% subjects were suffering from SRPD. About 85% of these subjects presented with aggressiveness and behavioral disturbance. Apart from 12% previously diagnosed cases of SRPD, 88% of the subjects were new cases. Conclusion: Aggressive behaviour is the principal presentation in psychiatric emergency services, and schizophrenia & related psychosis contribute a significant proportion of these cases. There is a high rate of previously undiagnosed subjects seeking treatment in emergency, highlighting the role of emergency psychiatric services in not just acute crisis management but also in initiating long term treatment.
    Preview · Article · Jan 2015
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    • "Supporting an additive risk model, val-homozygotes were assigned a score of 0, val-met heterozygotes were assigned a score of 1, and met-met homozygotes were assigned a score of 2. Thus, each met-allele was assumed to add to individual genetic risk as has been found with regard to other phenotypes, including aggression (Spalletta et al., 2010) and in interplay with maternal care on personality traits (Suzuki et al., 2011). "
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    ABSTRACT: Peer antisocial behavior robustly predicts adolescents' own behavior but not all adolescents are equally vulnerable to their peers' influence and genetic factors may confer vulnerability. This study used data of n = 3081 adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) to examine whether BDNF, a polymorphism that affects psychological functioning, moderates the association between affiliation with aggressive peers at age 10 and own aggression at age 15. A significant gene-environment interaction was found, where those who affiliated with aggressive peers in childhood showed increased risk for being aggressive in adolescence if they carried the BDNF met-met variant compared to val-val carriers. Our findings underline the importance of both biological and social factors for adolescent development.
    Full-text · Article · Mar 2014 · Journal of Research on Adolescence
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