Elimination of persistent toxicants from the human body

University of Alberta, 2935-66 Street, Edmonton, Alberta, Canada.
Human & Experimental Toxicology (Impact Factor: 1.75). 01/2011; 30(1):3-18. DOI: 10.1177/0960327110368417
Source: PubMed


There is compelling evidence that various chemical agents are important determinants of myriad health afflictions--several xenobiotics have the potential to disrupt reproductive, developmental, and neurological processes and some agents in common use have carcinogenic, epigenetic, endocrine-disrupting, and immune-altering action. Some toxicants appear to have biological effect at miniscule levels and certain chemical compounds are persistent and bioaccumulative within the human body. Despite escalating public health measures to preclude further exposures, many people throughout the world have already accrued a significant body burden of toxicants, placing them at potential health risk. As a result, increasing discussion is underway about possible interventions to facilitate elimination of persistent toxicants from the human organism in order to obviate health affliction and to potentially ameliorate chronic degenerative illness. An overview of the clinical aspects of detoxification is presented with discussion of established and emerging interventions for the elimination of persistent xenobiotics. Potential therapies to circumvent enterohepatic recirculation and a case report highlighting a clinical outcome associated with detoxification are also presented for consideration.

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Available from: Stephen Genuis, May 24, 2015
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    • "With recent recognition that various pollutants are neurotoxicants, there is emerging consideration of outcomes that might be achieved if measures are taken to eliminate the toxicant burden [66]. Recent research has highlighted assorted interventions that can be used to eliminate accrued persistent pollutants [67] [68] [69] [70] [71] [72] [73] [74]. Evidence of neuropsychiatric improvement has been observed with individuals receiving treatment to facilitate toxicant elimination of retained pollutants such as lead [70] and mercury [75]. "
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    ABSTRACT: Juxtaposed alongside the ongoing rise in the incidence and prevalence of dementia, is the surge of recent research confirming widespread exposure and bioaccumulation of chemical toxicants. Evidence from sources such as the Centers for Disease Control reveals that most people have accrued varying degrees of assorted toxic pollutants including heavy metals, flame retardants, and pesticide residues within their bodies. It has been well established that many of these toxicants have neurodegenerative as well as neurodevelopmental impact as a result of various pathophysiologic mechanisms including neuronal mitochondrial toxicity and disruption of neurotransmitter regulation. Elimination of stockpiled toxicants from the body may diminish adverse toxicant impact on human biology and allow restoration of normal physiological function. Incorporating a review of medical literature on toxicant exposure and dementia with a case history of a lead-exposed individual diagnosed with dementia, this paper will discuss a much overlooked and potentially widespread cause of declining brain function and dementia.
    Full-text · Article · Feb 2015 · Behavioural neurology
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    • "Public awareness campaigns may be effective in alerting individuals to concerns related to toxic element bioaccumulation and potential sources of exposure. Such awareness may facilitate further avoidance as well as medical intervention to eliminate accrued toxicants [48]. "
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    ABSTRACT: Background. Increasing concern is evident about contamination of foodstuffs and natural health products. Methods. Common off-the-shelf varieties of black, green, white, and oolong teas sold in tea bags were used for analysis in this study. Toxic element testing was performed on 30 different teas by analyzing (i) tea leaves, (ii) tea steeped for 3-4 minutes, and (iii) tea steeped for 15-17 minutes. Results were compared to existing preferred endpoints. Results. All brewed teas contained lead with 73% of teas brewed for 3 minutes and 83% brewed for 15 minutes having lead levels considered unsafe for consumption during pregnancy and lactation. Aluminum levels were above recommended guidelines in 20% of brewed teas. No mercury was found at detectable levels in any brewed tea samples. Teas contained several beneficial elements such as magnesium, calcium, potassium, and phosphorus. Of trace minerals, only manganese levels were found to be excessive in some black teas. Conclusions. Toxic contamination by heavy metals was found in most of the teas sampled. Some tea samples are considered unsafe. There are no existing guidelines for routine testing or reporting of toxicant levels in "naturally" occurring products. Public health warnings or industry regulation might be indicated to protect consumer safety.
    Full-text · Article · Oct 2013 · Journal of Toxicology
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    • "Oral clay has been reported to reduce body burdens of mycotoxins such as aflatoxins and fumonisins in lab animals and humans [42]. While clay compounds and zeolites have also been found to bind heavy metals and other toxins in water, soil, and other mediums [43], zeolites have thus far not been effective at removing PFCs [35]. As a significant proportion of the PFCs appear to persist in plasma bound to proteins, intermittent phlebotomy is currently being investigated as a means to rapidly diminish the body burden of PFCs. "
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    ABSTRACT: Background. While perfluorinated compounds (PFCs) are a family of commonly used synthetic compounds with many applications, some PFCs remain persistent within the human body due, in part, to enterohepatic recirculation and renal tubular reabsorption. With increasing recognition of potential harm to human health associated with PFC bioaccumulation, interventions to facilitate elimination of these toxicants are welcome in order to potentially preclude or overcome illness. Minimal research has been undertaken thus far on methods to accelerate human clearance of PFCs. Methods. To test for possible oral treatments to hasten PFC elimination, a group of individuals with elevated PFC levels was treated with cholestyramine (CSM) and, after a break, was subsequently treated with Chlorella pyrenoidosa (CP). Stool samples were collected from all participants (i) prior to any treatment, (ii) during treatment with CSM, and (iii) during treatment with CP. Results. With CSM treatment, significant levels of three distinct PFCs were found in all stools, while levels were mostly undetectable prior to treatment. Following treatment with oral CP, undetectable or very low levels of all PFCs were noted in each sample tested. Conclusion. CSM appears to facilitate elimination of some common PFCs and may have some role in the clinical management of patients with accrued PFCs.
    Full-text · Article · Sep 2013
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