Voxel-based morphometry in eating disorders: Correlation of psychopathology with grey matter volume

ArticleinPsychiatry Research 182(2):146-51 · May 2010with13 Reads
DOI: 10.1016/j.pscychresns.2010.02.004 · Source: PubMed
Twenty-nine adult female patients with eating disorders (17 with bulimia nervosa, 12 with restrictive anorexia nervosa) were compared with 18 age-matched female healthy controls, using voxel-based morphometry. Restrictive anorexia nervosa patients showed a decrease of grey matter, particularly affecting the anterior cingulate cortex, frontal operculum, temporoparietal regions and the precuneus. By contrast, patients with bulimia nervosa did not differ from healthy controls. A positive correlation of "drive for thinness" and grey matter volume of the right inferior parietal lobe was found for both eating disorder groups. The strong reduction of grey matter volume in adult patients with restrictive anorexia nervosa is in line with results of adolescent patients. Contrary to other studies, this first voxel-based morphometry report of bulimic patients did not find any structural abnormalities. The inferior parietal cortex is a critical region for sensory integration of body and spatial perception, and the correlation of "drive for thinness" with grey matter volume of this region points to a neural correlate of this core psychopathological feature of eating disorders.
    • "Our ROIs consisted of the anterior cingulate cortex (ACC) and the supplementary motor area (SMA). These regions were chosen due to frequent reports of reduced GM volume in these areas in both the ill [6,[21][22][23][24][25]and recovered AN state [3, 6, 7] , making them the most commonly reported loci of GM reduction in AN. The ACC was defined using a maximum probability atlas [26] , available from www.brain-development .org. "
    [Show abstract] [Hide abstract] ABSTRACT: Background: Anorexia nervosa (AN) has consistently been associated with reduced gray (GM) and white matter (WM) brain volumes. It is unclear whether GM alterations are present following recovery from AN, as previous findings are inconsistent. The aim of the present study was to determine if women recovered from AN exhibit reduced global or regional GM volumes. Methods: Global GM and WM, as well as regional GM volumes, were investigated in 22 women recovered from AN and 22 age-matched healthy controls using magnetic resonance imaging. Women were considered recovered if they had maintained a body mass index above 18.0 and had not engaged in binge eating, purging, or restrictive eating behaviors during the past year. Results: There were no significant differences between recovered AN women and healthy controls in terms of GM and WM volumes. There were also no significant differences between restricting and binging-purging AN subtypes. Lowest lifetime weight was positively correlated with regional GM volumes in the precuneus and insula. Conclusions: The present study showed that regional GM and global GM and WM volumes were similar for women long-term recovered from AN and age-matched healthy controls. Further research is needed to determine the extent to which illness severity affect regional GM volumes.
    Full-text · Article · Dec 2016
    • "In general, AN is characterized by volume reductions across the brain, and specifically in the regions highlighted below. The two most consistently observed regional volume reductions among individuals with AN are in the amygdala (Friederich et al., 2012; King et al., 2015) and the ACC (Boghi et al., 2011; Friederich et al., 2012; Joos et al., 2010; King et al., 2015; McCormick et al., 2008; Mühlau et al., 2007). Interestingly, amygdala (Friederich et al., 2012; King et al., 2015 ) and ACC volumes have been shown to normalize with treatment (King et al., 2015), suggesting that reduced amygdala and ACC volume may be state markers of AN that are sensitive to weight restoration. "
    [Show abstract] [Hide abstract] ABSTRACT: Major depression and eating disorders (EDs) are highly co-morbid and may share liability. Impaired emotion regulation may represent a common etiological or maintaining mechanism. Research has demonstrated that depressed individuals and individuals with EDs exhibit impaired emotion regulation, with these impairments being associated with changes in brain structure and function. The goal of this review was to evaluate findings from neuroimaging studies of depression and EDs to determine whether there are overlapping alterations in the brain regions known to be involved in emotion regulation, evidence of which would aid in the diagnosis and treatment of these conditions. Our review of the literature suggests that depression and EDs exhibit common structural and functional alterations in brain regions involved in emotion regulation, including the amygdala, ventral striatum and nucleus accumbens, anterior cingulate cortex, insula, and dorsolateral prefrontal cortex. We present preliminary support for a shared etiological mechanism. Future studies should consider manipulating emotion regulation in a sample of individuals with depression and EDs to better characterize abnormalities in these brain circuits.
    Article · Jul 2016
    • "GM changes in the hypothalamus (Boghi et al., 2011) and the right frontal and temporal cortical structures (Brooks et al., 2011; Amianto et al., 2013); GM changes in the cingulum correlated with lowest lifetime BMI (Muhlau et al., 2007). Still, other studies did not find any correlations of GM changes with BMI (Joos et al., 2010; Fonville et al., 2013). The amount of weight loss prior to admission was associated with global GM loss in one small study (Bomba et al., 2013). "
    [Show abstract] [Hide abstract] ABSTRACT: Acute anorexia nervosa (AN) is associated with marked brain volume loss potentially leading to neuropsychological deficits. However, the mechanisms leading to this brain volume loss and its influencing factors are poorly understood and the clinical relevance of these brain alterations for the outcome of these AN-patients is yet unknown. Brain volumes of 56 female adolescent AN inpatients and 50 healthy controls (HCs) were measured using MRI scans. Multiple linear regression analyses were used to determine the impact of body weight at admission, prior weight loss, age of onset and illness duration on volume loss at admission and to analyse the association of brain volume reduction with body weight at a 1-year follow-up (N = 25). Cortical and subcortical grey matter (GM) and cortical white matter (WM) but not cerebellar GM or WM were associated with low weight at admission. Amount of weight loss, age of onset and illness duration did not independently correlate with any volume changes. Prediction of age-adjusted standardized body mass index (BMI-SDS) at 1-year follow-up could be significantly improved from 34% of variance explained by age and BMI-SDS at admission to 47.5-53% after adding cortical WM, cerebellar GM or WM at time of admission. Whereas cortical GM changes appear to be an unspecific reflection of current body weight ("state marker"), cortical WM and cerebellar volume losses seem to indicate a longer-term risk (trait or "scar" of the illness), which appear to be important for the prediction of weight rehabilitation and long-term outcome. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Article · Sep 2015
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