Androgen Regulation of Gene Expression

ArticleinAdvances in Cancer Research 107:137-62 · December 2010with16 Reads
Impact Factor: 5.32 · DOI: 10.1016/S0065-230X(10)07005-3 · Source: PubMed

    Abstract

    The biological action of androgenic male sex steroid hormones in prostate tissue is mediated by the androgen receptor, a nuclear transcription factor. The transcriptional program of androgenic signaling in the prostate consists of thousands of gene targets whose products play a role in almost all cellular functions, including cellular proliferation, survival, lipid metabolism, and differentiation. This review will provide a summary of the most recent data regarding androgen-regulated target genes and modulation of androgen receptor activity, especially with regard to androgen-dependent and castration-recurrent prostate cancer.