Cucurbitane-Type Triterpenoids from Momordica charantia

ArticleinPlanta Medica 76(15):1758-61 · April 2010with8 Reads
Impact Factor: 2.15 · DOI: 10.1055/s-0030-1249807 · Source: PubMed

    Abstract

    One new cucurbitane-type triterpenoid glycoside, momordicoside U (1), together with five known cucurbitane-type triterpenoids and related glycosides, 3β,7 β,25-trihydroxycucurbita-5,23 (E)-dien-19-al (2), momordicine I (3), momordicine II (4), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia. Their structures were determined by chemical and spectroscopic methods. Momordicoside U (1) was evaluated for insulin secretion activity in an in vitro insulin secretion assay and displayed moderate activity.