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Erratum to: An empirical index of insulin sensitivity from short IVGTT: validation against the minimal model and glucose clamp indices in patients with different clinical characteristics

DOI:10.1007/s00125-010-1740-x
Authors:
Andrea Tura at Italian National Research Council
Andrea Tura
Stefano Sbrignadello at Italian National Research Council
Stefano Sbrignadello
Elena Succurro at Universita' degli Studi "Magna Græcia" di Catanzaro
Elena Succurro
L Groop
L Groop
L Groop
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ERRATUM
Erratum to: An empirical index of insulin sensitivity
from short IVGTT: validation against the minimal
model and glucose clamp indices in patients with different
clinical characteristics
A. Tura &S. Sbrignadello &E. Succurro &L. Groop &
G. Sesti &G. Pacini
Published online: 7 April 2010
#Springer-Verlag 2010
Erratum to: Diabetologia
DOI 10.1007/s00125-009-1547-9
Unfortunately the αconstant used in the CS
I
equation was
incorrectly stated in the Methods and Discussion sections as
being 0.276, whereas it should have read 0.604. The correct
αconstant was used in all calculations, and so this mistake
does not affect any of the results in the paper.
The online version of the original article can be found at http://dx.doi.
org/10.1007/s00125-009-1547-9.
A. Tura :S. Sbrignadello :G. Pacini (*)
Metabolic Unit, ISIB-CNR,
Corso Stati Uniti, 4,
35127 Padova, Italy
e-mail: giovanni.pacini@isib.cnr.it
E. Succurro :G. Sesti
Department of Experimental and Clinical Medicine,
University Magna Græcia of Catanzaro,
Catanzaro, Italy
L. Groop
Lund University Diabetes Centre, Lund University,
Malmö, Sweden
L. Groop
Research Program for Molecular Medicine, Helsinki University,
Helsinki, Finland
Diabetologia (2010) 53:1245
DOI 10.1007/s00125-010-1740-x
Methods and Models for Metabolic Assessment in Mice
Article
Full-text available
  • Jan 2013
The development of new therapies for the treatment of type 2 diabetes requires robust, reproducible and well validated in vivo experimental systems. Mice provide the most ideal animal model for studies of potential therapies. Unlike larger animals, mice have a short gestational period, are genetically similar, often give birth to many offspring at once and can be housed as multiple groups in a single cage. The mouse model has been extensively metabolically characterized using different tests. This report summarizes how these tests can be executed and how arising data are analyzed to confidently determine changes in insulin resistance and insulin secretion with high reproducibility. The main tests for metabolic assessment in the mouse reviewed here are the glucose clamp, the intravenous and the oral glucose tolerance tests. For all these experiments, including some commonly adopted variants, we describe: (i) their performance; (ii) their advantages and limitations; (iii) the empirical formulas and mathematical models implemented for the analysis of the data arising from the experimental procedures to obtain reliable measurements of peripheral insulin sensitivity and beta cell function. Finally, a list of previous applications of these methods and analytical techniques is provided to better comprehend their use and the evidences that these studies yielded.
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