NF-κB Fans the Flames of Lung Carcinogenesis

Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
Cancer Prevention Research (Impact Factor: 4.44). 03/2010; 3(4):403-5. DOI: 10.1158/1940-6207.CAPR-10-0042
Source: PubMed


This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-kappa B and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating protumorigenic roles of NF-kappa B activation in lung cancer pathogenesis. Our growing understanding of the tumor-promoting NF-kappa B downstream effector pathways could lead to the development of novel approaches for lung cancer therapy and chemoprevention. Cancer Prev Res; 3(4); 403-5. (C)2010 AACR.

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    • "NF-κB regulated genes include cytokines, adhesion molecules, angiogenic factors, anti-apoptotic factors, and matrix metalloproteinases (MMPs), which are involved in different steps of carcinogenesis. It has been suggested that NF-κB promotes lung cancer mainly through mediating inflammatory cytokines secretion to establish a cancer-prone inflammatory microenvironment [48]. Similarly, NF-κB pathways play a crucial role in the pathogenesis/development of COPD by increasing the release of pro-inflammatory mediators leading to chronic inflammation in the lung. "
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    • "Nuclear factor kappaB (NF-kB) plays a critical role in several biological processes, including cell cycle regulation [1e3], expression of specific genes [4] [5], regulation of cell differentiation [6] [7] and apoptosis [8e11]. On the other hand, alteration of NF-kB activity is associated with several human pathologies, including osteoporosis [12], rheumatoid arthritis [13] and cancer [14] [15]. In addition, NF-kB is one among the master transcription factors responsible for inflammation in cystic fibrosis (CF) cells infected with Pseudomonas aeruginosa [16e20]. "
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