Time-of-Day-Dependent Dietary Fat Consumption Influences Multiple Cardiometabolic Syndrome Parameters in Mice

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
International journal of obesity (2005) (Impact Factor: 5). 03/2010; 34(11):1589-98. DOI: 10.1038/ijo.2010.63
Source: PubMed


Excess caloric intake is strongly associated with the development of increased adiposity, glucose intolerance, insulin resistance, dyslipidemia, and hyperleptinemia (that is the cardiometabolic syndrome). Research efforts have focused attention primarily on the quality (that is nutritional content) and/or quantity of ingested calories as potential causes for diet-induced pathology. Despite growing acceptance that biological rhythms profoundly influence energy homeostasis, little is known regarding how the timing of nutrient ingestion influences development of common metabolic diseases.
To test the hypothesis that the time of day at which dietary fat is consumed significantly influences multiple cardiometabolic syndrome parameters.
We report that mice fed either low- or high-fat diets in a contiguous manner during the 12  h awake/active period adjust both food intake and energy expenditure appropriately, such that metabolic parameters are maintained within a normal physiologic range. In contrast, fluctuation in dietary composition during the active period (as occurs in human beings) markedly influences whole body metabolic homeostasis. Mice fed a high-fat meal at the beginning of the active period retain metabolic flexibility in response to dietary challenges later in the active period (as revealed by indirect calorimetry). Conversely, consumption of high-fat meal at the end of the active phase leads to increased weight gain, adiposity, glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and hyperleptinemia (that is cardiometabolic syndrome) in mice. The latter perturbations in energy/metabolic homeostasis are independent of daily total or fat-derived calories.
The time of day at which carbohydrate versus fat is consumed markedly influences multiple cardiometabolic syndrome parameters.

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    • "). It is now well established that the temporal pattern of food consumption can profoundly affect weight gain and adiposity independent of total caloric intake (Arble et al., 2009; Bray et al., 2010; Hatori et al., 2012; Chaix et al., 2014). The increased adiposity in circadian mutant mice could also reflect increased lipid accumulation due to increased lipogenesis or decreased lipolysis, which will be discussed further below. "
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    No preview · Article · Apr 2015 · Journal of Biological Rhythms
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    • "Feeding regular chow diet during daytime alters energy balance in nocturnal mice, as compared to animals fed only during the night (Bray et al., 2013). When mice are forced to eat a high-fat diet during the light phase or at the end of the night, metabolic perturbations occur, inducing increased adiposity and decreased glucose tolerance (Arble et al., 2009; Bray et al., 2010). Furthermore, restricting high-fat feeding only to the active period of animals attenuates body weight gain and improves glucose and lipid metabolism (Hatori et al., 2012; Tsai et al., 2013). "
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