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Albendazole Pada Soil Transmitted Helminthiasis

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Abstract

Kecacingan masih merupakan problema kesehatan dan ekonomi yang utama pada masyarakat, pekerja maupun individu. Oleh CHAIRUDDIN P. LUBIS dkk anak-chairuddin12

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... In areas with poor sanitation, the prevalence can reach as high as 80% [2]. In different districts in North Sumatra province, the prevalence of helminthiasis in suburban and rural areas have been reported from 87% in 2004, 84.6% in 2005, 64.3% in 2012 to 84.66% in 2015 [3], [4], [5], [6], [7], [8], [9]. Helminthiasis affects the nutritional status and cognitive function of the children, and in the long-term may interfere with their growth [10]. ...
... Further, we also assessed the hygiene behaviour in those children. Similar to our earlier studies in other districts in North Sumatra province, the prevalence of STH infections remains high [3], [4], [5], [6], [7], [8], [9], [13], despite existing health promotion and education to reduce STH burden. Therefore, in this study, we complemented our data with the information regarding basic knowledge of STH infection, how they transmit and STH risk behaviours. ...
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Background: Soil-transmitted helminth (STH) infection remains of public health importance, particularly in developing countries. North Sumatra province of Indonesia has reported high prevalences of STH in many of its districts. Aim: In this study, we aimed to determine the prevalence of STH and evaluated STH knowledge and risk behaviours of school children in Mandailing Natal district. Methods: We conducted a cross-sectional study in two primary schools in Mandailing Natal district, North Sumatera province, Indonesia. Data were collected directly from the subjects using a questionnaire after receiving consent from their parents. A stool sample was also collected to determine the STH status of each subject. Samples were then transported to the parasitology laboratory at Universitas Sumatera Utara in Medan to be analysed by a trained analyst. Kato-Katz method was used to prepare the slides (World Health Organization, 2002). The intensity of infection is classified into light, moderate and heavy infection. Results: Prevalence of STH infections were 76.8% and 87.2% in Singkuand and Sikapas primary schools, respectively. The majority of infections were Ascaris lumbricoides and Trichuris trichiura at a light intensity. Only small numbers of children in the two schools used soap before eating, used soap after defecating, and wear sandal/shoes when walking outdoor. Less than 50% of children also knew the route of transmission of STH. Poorer knowledge and behaviours were shown in children from Sikapas than in Singkuang. Conclusion: High prevalence and poor hygiene behaviours found in this study reinforce the need to identify the correct intervention to address this STH problem in the region.
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Objective This study aims to assess the efficacy of single-dose albendazole in treating mild, moderate, and severe ascariasis. Methods Stool specimens were collected from randomly selected elementary school children in Suka village, Sumatera Utara, from March to April 2002. Based on the number of eggs per gram feces (NEPG), samples were categorized as mild (NEPG < 7000), moderate (NEPG 7000-35,000), or severe (NEPG > 35,000) ascariasis. All subjects then received 400 mg albendazole orally. NEPG count was repeated on the yth, 14th , 21 st and 28th day after treatment. The chi-square test was used to compare cure rates between subjects with mild, moderate, and severe ascariasis. The ANOVA and Kruskal-Wallis tests were employed to analyze quantitative data. Results From the 134 specimens collected, we found mild ascariasis in 57 (42.5%), moderate ascariasis in 57 (42.5%), and severe ascariasis in 20 (15%). There was no significant difference between the three groups in NEPG after treatment (P>0.05). The cure rate and egg reduction rate on day 28 after treatment was 100%. Conclusion A single dose of 400 mg albendazole is effective for the treatment of mild, moderate, and severe ascariasis. Paediatrica Indonesiana
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