Sildenafil Increases Uterine Blood Flow in Nonpregnant Nulliparous Women

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, Vermont 05405, USA.
Reproductive sciences (Thousand Oaks, Calif.) (Impact Factor: 2.23). 04/2010; 17(4):358-65. DOI: 10.1177/1933719109354648
Source: PubMed


This study investigated the effect of sildenafil on uterine volumetric blood flow (UVF) and vascular impedance in nonpregnant, nulliparous women. Fifteen women were randomized in a double-blind fashion to receive either placebo or sildenafil (25 or 100 mg) during the luteal phase of the menstrual cycle. Color Doppler ultrasound of both uterine arteries was performed at baseline and at 1 and 3 hours postdosing to calculate resistance index (RI) and UVF. Those who received sildenafil significantly increased UVF and decreased RI over the 3-hour monitoring period. When UVF responses to sildenafil were examined as a function of baseline UVF, a significant increase in UVF was observed in only those participants with higher baseline UVF. Overall, women in the luteal phase demonstrated a significant increase in UVF in response to sildenafil. However, this increase appears to be directly associated with basal UVF.

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    • "Although in the human male adults treatment for erectile dysfunction is the main indication for PDE5administration, in recent years a search for new applications of this drug has been initiated (Boyce and Umland, 2001; Dishy et al., 2001; Paulus et al., 2002; Alatas and Yaqci, 2004). Most of them were related to the reproductive organs and concentrated on the question of increased fertility in the women undergoing IVF/ET procedures after intravaginal administration of the sildenafil (Sher et al., 2000; Fisch and Sher, 2002; Sher and Fisch, 2002; Chanona et al., 2004; Margreiter et al., 2004; Sher and Fisch, 2004; Vidal et al., 2004; Sher et al., 2007; Hale et al., 2010). "
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