African Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity

Georgetown University, Washington, Washington, D.C., United States
Tissue Antigens (Impact Factor: 2.14). 03/2010; 76(1):31-4. DOI: 10.1111/j.1399-0039.2010.01460.x
Source: PubMed


KIR2DL1 alleles were identified by DNA sequencing of the coding region from amplified genomic DNA from 100 random African Americans. The majority of individuals (97%) carried a KIR2DL1 locus. Allele KIR2DL1*00302 was found in 68% of individuals but KIR2DL1*00401, *002, *00303, *006, and *007 were also frequent. Eleven new alleles were described: KIR2DL1*00403, *01101, *01102, *012, *013N, *014, *015, *016, *017, *018, and *019. Nine of the novel alleles encoded amino acid substitutions located throughout the receptor; one allele carried a stop codon in the exon encoding the first extracellular domain.

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