Article

Cytokine evaluation in individuals with low back pain using discographic lavage

New York University Hospital for Joint Diseases, New York, NY 10003, USA.
The spine journal: official journal of the North American Spine Society (Impact Factor: 2.43). 03/2010; 10(3):212-8. DOI: 10.1016/j.spinee.2009.12.007
Source: PubMed

ABSTRACT

The pathophysiology underlying degenerative disc disease and its implication in painful syndromes remain unclear. However, spine magnetic resonance imaging (MRI) can demonstrate changes in disc water content and the annulus; provocative discography purportedly identifies degenerate discs causing serious low back pain; and biochemical assays have identified local inflammatory markers. No study to date has correlated pain on disc injection during discography evaluation with relevant MRI findings and biochemical markers.

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