Does D matter? The role of vitamin D in hair disorders and hair follicle cycling

Department of Dermatology, University of Texas and MD Anderson Cancer Center, Houston, Texas, USA.
Dermatology online journal 02/2010; 16(2):3.
Source: PubMed


The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology.
We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders.
A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss.
The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.
The review is broad and there are limited human studies available to date.
Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.

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    • "Vitamin D is a steroid hormone that regulates several endocrine functions and cell functions such as, proliferation and differentiation. [8] [9]. The 1,25(OH) 2 D is one of potent regulators of cell growth and differentiation, which is an effect on cell death, tumor invasion, and angiogenesis, which makes it a candidate compound for cancer regulation [9]. "
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    ABSTRACT: Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.
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    ABSTRACT: The patient with hair loss invariably complains “I am losing my hair,” which can mean vastly different things in different patients. Every patient with hair loss should have the following baseline lab studies: CBC, TSH, ferritin, and vitamin D 25OH because you do not want to miss other possible contributing factors of hair loss. KeywordsOstia-Scalp biopsy-Patient evaluation-Hair Card-Anagen hairs-Tug Test
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