Population study about the attitude toward organ xenotransplantation in the population from Eastern Europe resident in southeast Spain

Article · January 2010with6 Reads
Source: PubMed
Abstract
The objective of this paper is to analyze the attitude toward xenotransplantation and to determine the variables that influence this attitude in the population of southeast Spain who were born in Eastern European countries. A random sample was taken of natives from Eastern Europe residing in southeast Spain (n=320). The sample was obtained randomly between November 2005 and April 2006 and stratified according to the respondents' nationality. Attitude was evaluated using a validated questionnaire which was self-administered and completed anonymously. The control group was a random sample of the native Spanish population (n=250). The statistical analysis used included Student's t-test, the chi-square test, Fisher's exact test, and a logistic regression analysis. The questionnaire completion rate was 83% (n=267). Regarding the use of animal organs for transplantation in humans, if the outcome were similar to that achieved when using human organs, 43% (n=114) would be in favor, 32% (n=86) undecided, and the remaining 25% (n=67) would be against it. This attitude is less favorable than in the control group (43% versus 74%, p<0.001). The attitude was related to the following factors: 1) the country of origin (p<0.001); 2) participation in social help activities (p<0.001); 3) discussion on organ donation and transplantation within the family (p=0.005); 4) previous experience of organ donation and transplantation (p=0.002); 5) the respondent's religion (p=0.002); 6) knowing that one's partner had a favorable attitude toward transplantation (p<0.001); 7) the respondent's belief that he or she might need a transplant in the future (p<0.001); 8) the attitude toward human donation, both from cadaver (p<0.001) and living (p<0.001) donors. The following were also independent variables in the subsequent multivariate analysis: 1) favorable attitude toward cadaver organ donation (OR=4.998); 2) previous experience of donation (0R=2.857); 3) partner's attitude against transplantation (OR=0.079); and 4) attitude toward living donation (OR=12. 703). The attitude toward xenotransplantation is less positive among Eastern Europeans living in Spain than in the native Spanish population and is influenced by many psychosocial factors that are mainly related to human organ donation.
  • [Show abstract] [Hide abstract] ABSTRACT: The transplantation of pancreatic islets from animals as a treatment for diabetes mellitus could help with the current diabetes problem. Considerable advances have been made in recent years, with recent publications reporting improved conditions for carrying out clinical trials using porcine islets in humans with type 1 diabetes. Our objectives were (1) to analyze the acceptance of cell xenotransplantation for diabetes among Spanish adolescents and (2) to determine the psychosocial variables that might affect their attitudes and its relationship with other types of donation. Random sampling was carried out among secondary school students in Spanish Schools. All subjects completed a validated questionnaire evaluating the acceptance of pancreatic islet xenotransplantation together with psychosocial aspects. Questionnaire completion was anonymous and self-administered. Student t test and the chi-square test were used for statistics. The total number of respondents surveyed was 3633, and the mean age of the respondents was 11 ± 18 years. Most of the respondents (62%; n = 2195) would accept cells of animal origin if they suffered diabetes, 28% (n = 1005) were unsure, and 10% (n = 340) were against xenotransplantation. There is no connection with sex, age/year of study, or country. A high level of acceptance of animal cells was found among those who had a favorable attitude toward deceased organ donation and the xenotransplantation of solid organs and animal tissues (P < .001). Among Spanish adolescents, there was a good level of acceptance of the idea of using animal cells as a treatment for diabetes mellitus. Therefore, it would be beneficial to increase the information provided about these matters in secondary education to improve awareness further, as part of the general human organ donation and transplantation promotion campaigns.
    Full-text · Article · Feb 2011
  • [Show abstract] [Hide abstract] ABSTRACT: Objective. Because of the shortage of organs, it has become necessary to look for alternative sources of organs, such as xenotransplantation. The aim of this study was to analyze the attitude of nursing students at a university in the Eastern Poland toward xenotransplantation, to determine factors that affect their acceptance. Material and Method. During the 2011-2012 academic year, nursing students at the University of the Eastern Poland enrolled the 5 nursing courses self-administered a validated questionnaire (the PCID-XenoTx Rios) anonymously. We undertook a descriptive statistical analysis using the Student t test, chi(2) test, and logistic regression analysis. Results. The completion rate was 90% (608 of 672). When asked about the acceptability of organ donation from humans, 62% (n = 379) were in favor, 9% (n = 54) against, and 29% (n = 175) undecided. We found a significant association between the acceptability of transplantation and the university course and the respondents' religion (P < .05). Fourth-year students have a more favorable attitude toward xenotransplantation than third-year students (75% vs 54%; P = .018). Catholics accept this type of donation more readily than those belonging to other faith traditions (63% vs 37%; P = .053). In the multivariate analysis, academic course is a significant influence on attitude toward xenotransplantation (odds ratio, 2.421; 95% CI, 4.347-1.345; P = .003). Conclusions. Nursing students have an unfavorable attitude toward xenotransplantation. This attitude is influenced by the religious beliefs and their academic year.
    Article · Nov 2015