Soft Drink and Juice Consumption and Risk of Pancreatic Cancer: The Singapore Chinese Health Study

Cancer Control Program, Georgetown University Medical Center, Washington, District of Columbia, USA.
Cancer Epidemiology Biomarkers & Prevention (Impact Factor: 4.13). 02/2010; 19(2):447-55. DOI: 10.1158/1055-9965.EPI-09-0862
Source: PubMed


Sugar-sweetened carbonated beverages (called soft drinks) and juices, which have a high glycemic load relative to other foods and beverages, have been hypothesized as pancreatic cancer risk factors. However, data thus far are scarce, especially from non-European descent populations. We investigated whether higher consumption of soft drinks and juice increases the risk of pancreatic cancer in Chinese men and women.
A prospective cohort analysis was done to examine the association between soft drink and juice consumption and the risk of pancreatic cancer in 60,524 participants of the Singapore Chinese Health Study with up to 14 years of follow-up. Information on consumption of soft drinks, juice, and other dietary items, as well as lifestyle and environmental exposures, was collected through in-person interviews at recruitment. Pancreatic cancer cases and deaths were ascertained by record linkage of the cohort database with records of population-based Singapore Cancer Registry and the Singapore Registry of Births and Deaths.
The first 14 years for the cohort resulted in cumulative 648,387 person-years and 140 incident pancreatic cancer cases. Individuals consuming > or = 2 soft drinks/wk experienced a statistically significant increased risk of pancreatic cancer (hazard ratio, 1.87; 95% confidence interval, 1.10-3.15) compared with individuals who did not consume soft drinks after adjustment for potential confounders. There was no statistically significant association between juice consumption and risk of pancreatic cancer.
Regular consumption of soft drinks may play an independent role in the development of pancreatic cancer.

Download full-text


Available from: Noel T Mueller
  • Source
    • "Analiza ryzyka u osób, które spożywały tylko soki owocowe nie wykazała żadnego istotnie statystycznego związku z zachorowalnością na raka trzustki. Analiza statystyczna z uwzględnieniem innych czynników, takich jak BMI, występowanie cukrzycy typu 2 oraz palenie papierosów nie zmieniła wyników w żadnym z tych dwóch przypadków [57]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Treatment of cancer involves not only appropriate pharmacological or psychological therapy and rehabilitation, but also diet aimed at prevention of the process of cachexia. Postprandial hyperglycemia exerts a significant effect on the growth and proliferation of tumor cells. It promotes formation of a number of metabolic changes in every tissue of the organism. Chronic postprandial hyperglycemia, occurring in type 2 diabetes, enhances all these changes. Although the results of epidemiological studies on the relationship between the overall risk of cancer development, or tumors in different parts of the organism, are heterogeneous, most of them indicate that the risk increases with an increase in glycemic load of the examined population's diets. Researchers also suggest a beneficial effect of limiting the amount of easily assimilable carbohydrate in the diet to stabilize the disease and for better tolerance of chemoor radiation therapy. However, further studies are required.
    Full-text · Article · Jan 2013 · Postępy Higieny i Medycyny Doświadczalnej (Advances in Hygiene and Experimental Medicine)
  • Source
    • "Despite difficulty with many statistical ideas, big and small, the overwhelming mistake that journalists make in writing about health involves their addiction to the immediate, most recent study on any topic. For example, a recent study of Chinese men in Singapore (Mueller, 2010) came out pointing to increased risk of pancreatic cancer associated with soda consumption. The media described this result with little reference to the scientific literature around the topic and often with no qualifiers. "
    [Show abstract] [Hide abstract]
    ABSTRACT: News increasingly depends on a careful dissection of numbers. Statistics are everywhere, from how many people are not covered by health insurance to whether Vitamin E is good for you or not. Yet for being so prevalent, statistics are badly understood by journalists and the general public. Misguided representations of science can actually shape public policy, legislation, and individual choices. We describe why it is so important that media writers understand basic concepts from statistics, epidemiology and even toxicology using examples in current media coverage. We also discuss the gulf between the scientific and media cultures, which can lead to bad science coverage. We finish with constructive suggestions for improvements in communication of scientific progress by media writers. BACKGROUND It may be a national pastime to deride the media. As we discuss below, scientists have little confidence that most media outlets can talk about issues involving statistics cogently. Statistics education has slowly started to be recognized as having central importance in a newly data-drive society. While much statistical education is school-based, there is without a doubt a need to improve the understanding of statistics by those who use it in a public forum, such as journalists. In this essay, we describe some of the perceptions that scientists have about media sources of information, and then continue to discuss some of challenges that journalists face in using statistics effectively in their work. Much, much more can be found at the website for Statistical Assessment Service (STATS), where I am Director of Research. This role, in addition to my "main" appointment as a professor of mathematics at George Mason University, has led me on an unusual path toward non-institutional public education.
    Full-text · Article ·
  • [Show abstract] [Hide abstract]
    ABSTRACT: Soft drinks usually contain sugar and caffeine that might influence pancreatic carcinogenesis. We considered the association between carbonated drink consumption and pancreatic cancer risk in an Italian case-control study conducted in 1991-2008 on 326 pancreatic cancer cases and 652 matched controls. We also combined the results from all the studies on soft drinks or sweetened beverages and pancreatic cancer published before June 2010, using a meta-analytic approach. In the case-control study, compared with non-drinkers, the multivariate odds ratio was 1.02 (95% confidence interval, CI, 0.72-1.44) for carbonated drink consumers and 0.89 (95% CI 0.53-1.50) for regular consumers (at least one drink/day). Besides our study, from the literature search, we identified 4 other case-control (1,919 cases) and 6 cohort studies (2,367 cases). The pooled relative risks (RR) for soft drink consumers vs. non-consumers were 0.97 (95% CI 0.81-1.16) for case-control, 1.05 (95% CI 0.94-1.17) for cohort, and 1.02 (95% CI 0.93-1.12) for all studies. The pooled RRs for heavy drinkers were 1.08 (95% CI 0.73-1.60) for case-control, 1.21 (95% CI 0.90-1.63) for cohort, and 1.16 (95% CI 0.93-1.45) for all studies. In conclusion, soft drink consumption is not materially related to pancreatic cancer risk.
    No preview · Article · Oct 2010 · Cancer Causes and Control
Show more