Identification of a new human leukocyte antigen A allele, HLA-A * 3020

ArticleinZhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 27(1):96-9 · February 2010with2 Reads
DOI: 10.3760/cma.j.issn.1003-9406.2010.01.021 · Source: PubMed

    Abstract

    To identify a novel human leukocyte antigen (HLA) A allele.
    A new HLA-A allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).
    The novel HLA-A*30 allele was identical to A*300101 except that a nucleotide C at position 294 of exon 2 is substituted by A, resulting in codon 98 changed from GAC (D) to GAA (E).
    A new HLA allele, HLA-A*3020, was identified, and was named officially by the WHO Nomenclature Committee.