Prevalence of Mycobacterium tuberculosis Infection in Children in Western Uttar Pradesh

Mangla Hospital, Shakti Chowk, Bijnor, Uttar Pradesh, India.
Indian pediatrics (Impact Factor: 1.04). 05/2010; 47(1):97-100. DOI: 10.1007/s13312-010-0013-6
Source: PubMed


This study was conducted to estimate the prevalence of tubercular infection and compute the Annual risk of tuberculosis infection (ARTI) in Bijnor district of western Uttar Pradesh through a hospital-based tuberculin survey conducted at a pediatric hospital. A total of 1085 children below 18 years (0-4 years 866, 5-17 years 219), attending the out-patient department during October 2007 through September 2008 were included. Tuberculin skin test using standard PPD RT23 with Tween 80 was performed on every 4th child attending the out-patient department and induration was measured after 48 to 72 hours. Using a cut-off of 15 mm among 0-4 y aged children, the average prevalence rate was 7.4%, and using cut-off of 10 mm in 5-17 y age group the average prevalence rate was 26.9%. ARTI was 4.11% (95% CI 3.09-5.14) and 3.50 % (2.46-4.48), respectively in the two age groups.

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    • "RT23 is the most widely used PPD product globally (Rangel- Frausto et al., 2001). Several studies throughout the world have used PPD RT23 to estimate the prevalence of infection with the tubercle bacillus, including India (Rao et al., 2008; Vashishtha & John, 2010), Ghana (Addo et al., 2010), Yemen (Al-Absi et al., 2009), South Africa (Hanifa et al., 2009; Kritzinger et al., 2009), Nepal (Shrestha et al., 2008), Brazil (Lopes et al., 2008), and Indonesia (Bachtiar et al., 2008). In addition, it has also been used to evaluate large-scale TB contacts in the Netherlands (Borgen et al., 2008). "
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    ABSTRACT: The tuberculin skin test, which involves monitoring the immune reaction to an injection of Purified Protein Derivative (PPD), has been the most widely used method for detecting infection with Mycobacterium tuberculosis since its development in 1930s. Until recently, the molecular composition of PPD was unknown. This thwarted the discovery of improved skin testing reagents and drastically hindered efforts to define the mechanism of action. Proteomic evaluation of PPD combined with a detailed analysis in the guinea pig model of tuberculosis led to further definition of the molecular composition of PPD. This communication reviews the history and current status of PPD, in addition to describing candidate next-generation PPD reagents, based on the use of an individual protein or protein cocktails. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
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