Sexually diergic, dose-dependent hypothalamic-pituitary-adrenal axis responses to nicotine in a dynamic in vitro perfusion system

Department of Biology, Saint Vincent College, Latrobe, Pennsylvania 15650, USA.
Journal of pharmacological and toxicological methods (Impact Factor: 2.39). 05/2010; 61(3):311-8. DOI: 10.1016/j.vascn.2010.01.009
Source: PubMed


The hypothalamic–pituitary–adrenal cortical (HPA) axis modulates physiological responses to stress. We previously reported sexually diergic, dose-dependent HPA responses in vivo following nicotine administration: Male rats had greater arginine vasopressin (AVP) responses than females, and female rats had greater adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses than males. The goal of the present study was to further investigate sexually diergic, dose-dependent HPA responses following nicotine addition to an in vitro model of the HPA axis, so that hormone output could be determined at each level of the axis.

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