Article

Lycorine and its Derivatives for Anticancer Drug Design

Laboratoire de Chimie Analytique,Toxicologie et Chimie Physique Appliquée, Institut de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.
Mini Reviews in Medicinal Chemistry (Impact Factor: 2.9). 01/2010; 10(1):41-50. DOI: 10.2174/138955710791112604
Source: PubMed

ABSTRACT

Amaryllidaceae alkaloids are extensively studied for their biological activities in several pharmaceutical areas, including, for example, Alzheimer's disease for which galanthamine has already reached the market. Among this chemical family, lycorine displays very promising anti-tumor properties. This review first focuses on the chemical diversity of natural and synthetic analogues of lycorine and their metabolites, and then on mechanisms of action and biological targets through which lycorine and its derivatives display their anti-tumor activity. Our analysis of the structure-activity relationships of this family of compounds highlights the existence of various potential leads for the development of novel anticancer agents.

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    • "The present observations on structure activity relationship (SAR) are similar to those of previous findings regarding lycorine-and haemanthamine-type skeletons [25] [26]. In the present study there were five lycorine type AAs (lycorine, galanthine, tortuosine, ungeremine and zephgrabetaine). "
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    ABSTRACT: Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.
    Full-text · Article · Feb 2013 · Natural product communications
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    • "The present observations on structure activity relationship (SAR) are similar to those of previous findings regarding lycorine-and haemanthamine-type skeletons [25] [26]. In the present study there were five lycorine type AAs (lycorine, galanthine, tortuosine, ungeremine and zephgrabetaine). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.
    Full-text · Article · Feb 2013 · Natural product communications
  • Source
    • "The present observations on structure activity relationship (SAR) are similar to those of previous findings regarding lycorine-and haemanthamine-type skeletons [25] [26]. In the present study there were five lycorine type AAs (lycorine, galanthine, tortuosine, ungeremine and zephgrabetaine). "

    Full-text · Dataset · Jan 2013
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