"Does Periodontal Therapy Reduce the Risk for Systemic Diseases?"

Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Foster Hall, Buffalo, NY 14214, USA.
Dental clinics of North America 01/2010; 54(1):163-81. DOI: 10.1016/j.cden.2009.10.002
Source: PubMed


Periodontal disease is treated by various approaches, including simple oral hygiene practices, professional mechanical debridement, antimicrobial therapy and periodontal surgery. There is evidence to associate periodontal disease with several systemic diseases and conditions, including myocardial infarction, adverse pregnancy outcomes, diabetes mellitus, and respiratory disease. This article reviews the published literature that describes the effects of periodontal treatment on cardiovascular diseases, adverse pregnancy outcomes, diabetes mellitus, and respiratory disease. While some progress has been made, further research is required to understand the value of periodontal interventions in the prevention of systemic diseases.

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Available from: Frank Scannapieco
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    • "Knowledge about the link between periodontal disease and systemic health is growing rapidly. Increasing evidence is available indicating periodontitis as a risk factor for various systemic diseases such as cardiovascular diseases, diabetes mellitus, low birth weight infants and pulmonary diseases (Cullinan et al., 2009; Scannapieco et al., 2010). To date, the bulk of evidence points to the higher levels of circulating periodontal bacterial components, such as endotoxins, that could travel via blood to other organs in the body and cause harm (Dave and Van Dyke, 2008). "

    Full-text · Dataset · Jun 2014
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    • "Periodontitis, a chronic infectious inflammatory disease, is highly prevalent among world populations [1]. Recently, it has been generally accepted that periodontal disease is not only an important impact factor to human oral health but also a critical risk factor promoting several systemic diseases [2]. A number of studies have indicated that the main pathogen of periodontal disease is the bacterial plaque accumulation predominantly including Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans [3–5]. "
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    ABSTRACT: Periodontal disease characterized by alveolar bone resorption and bacterial pathogen-evoked inflammatory response has been believed to have an important impact on human oral health. The aim of this study was to evaluate whether magnolol, a main constituent of Magnolia officinalis, could inhibit the pathological features in ligature-induced periodontitis in rats and osteoclastogenesis. The sterile, 3-0 (diameter; 0.2 mm) black braided silk thread, was placed around the cervix of the upper second molars bilaterally and knotted medially to induce periodontitis. The morphological changes around the ligated molars and alveolar bone were examined by micro-CT. The distances between the amelocemental junction and the alveolar crest of the upper second molars bilaterally were measured to evaluate the alveolar bone loss. Administration of magnolol (100 mg/kg, p.o.) significantly inhibited alveolar bone resorption, the number of osteoclasts on bony surface, and protein expression of receptor activator of nuclear factor- κ B ligand (RANKL), a key mediator promoting osteoclast differentiation, in ligated rats. Moreover, the ligature-induced neutrophil infiltration, expression of inducible nitric oxide synthase, cyclooxygenase-2, matrix metalloproteinase (MMP)-1 and MMP-9, superoxide formation, and nuclear factor- κ B activation in inflamed gingival tissues were all attenuated by magnolol. In the in vitro study, magnolol also inhibited the growth of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans that are key pathogens initiating periodontal disease. Furthermore, magnolol dose dependently reduced RANKL-induced osteoclast differentiation from RAW264.7 macrophages, tartrate-resistant acid phosphatase (TRAP) activity of differentiated cells accompanied by a significant attenuation of resorption pit area caused by osteoclasts. Collectively, we demonstrated for the first time that magnolol significantly ameliorates the alveolar bone loss in ligature-induced experimental periodontitis by suppressing periodontopathic microorganism accumulation, NF- κ B-mediated inflammatory mediator synthesis, RANKL formation, and osteoclastogenesis. These activities support that magnolol is a potential agent to treat periodontal disease.
    Full-text · Article · Mar 2013 · Evidence-based Complementary and Alternative Medicine
    • "The oral hygiene status of the case group was significantly poor as compared to the control group in the present study. Scannapieco, et al., reported that poor oral hygiene is associated with many systemic diseases, one of which is myocardial infarction.[21] Karhunen, et al., stated that low oral hygiene was related to an increased risk of sudden cardiac death.[22] "
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    ABSTRACT: To assess the periodontal status among the patients suffering from acute myocardial infarction (AMI) and to investigate whether periodontitis is a risk factor for AMI or not. A cross-sectional study of 60 subjects, 30 subjects in each AMI group and control group was conducted. Details of risk factors like age, sex, smoking, and alcohol consumption were obtained through a personal interview. Medical history was retrieved from the medical file. The oral hygiene status was assessed by using a simplified oral hygiene index (OHI-S) and the periodontal status was assessed by community periodontal index (CPI) and loss of attachment (LOA) as per World Health Organization (WHO) methodology 1997. Chi-square test was used to analyze qualitative data whereas t-test and one way analysis of variance (ANOVA) test was used for quantitative data. Multiple regression model was applied to check the risk factors for AMI. The mean OHI-S score for case and control group was 3.98 ± 0.70 and 3.11 ± 0.68, respectively, which was statistically highly significant ( P < 0.001). There was high severity of periodontitis (for both in terms of CPI and LOA) in the case group as compared with control group, that was found to be statistically highly significant ( P < 0.001). There was a significant result for OHI-S and LOA score with odds ratio of 0.13 and 0.79, respectively, when the multiple logistic regression model was applied. The results of the present study show evidence that those patients who have experienced myocardial infarction exhibit poor periodontal conditions in comparison to healthy subjects and suggest an association between chronic oral infections and myocardial infarction.
    No preview · Article · Mar 2013 · Heart Views
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