ChemInform Abstract: Annulation of Thioimidates and Vinyl Carbodiimides to Prepare 2-Aminopyrimidines, Competent Nucleophiles for Intramolecular Alkyne Hydroamination. Synthesis of (-)-Crambidine

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Journal of the American Chemical Society (Impact Factor: 12.11). 02/2010; 132(6):1802-3. DOI: 10.1021/ja910831k
Source: PubMed
A convergent synthesis of (-)-crambidine is reported. The sequence capitalizes on two novel key transformations, including a [4+2] annulation of thioimidates with vinyl carbodiimides and an alkyne hydroamination employing 2-aminopyrimidine nucleophiles.


Available from: Sudeep Prajapati, Oct 05, 2015