Article

Depression and Cancer Mortality: A Meta-Analysis

Department of Psychology, Philipps University, Marburg, Germany.
Psychological Medicine (Impact Factor: 5.94). 11/2010; 40(11):1797-810. DOI: 10.1017/S0033291709992285
Source: PubMed

ABSTRACT

The goal of the present study was to analyze associations between depression and mortality of cancer patients and to test whether these associations would vary by study characteristics.
Meta-analysis was used for integrating the results of 105 samples derived from 76 prospective studies.
Depression diagnosis and higher levels of depressive symptoms predicted elevated mortality. This was true in studies that assessed depression before cancer diagnosis as well as in studies that assessed depression following cancer diagnosis. Associations between depression and mortality persisted after controlling for confounding medical variables. The depression-mortality association was weaker in studies that had longer intervals between assessments of depression and mortality, in younger samples and in studies that used the Beck Depression Inventory as compared with other depression scales.
Screening for depression should be routinely conducted in the cancer treatment setting. Referrals to mental health specialists should be considered. Research is needed on whether the treatment of depression could, beyond enhancing quality of life, extend survival of depressed cancer patients.

Download full-text

Full-text

Available from: Martin Pinquart
  • Source
    • "For the population in general, the depression prevalence rates, according to the study that compiled epidemiological data coming from 18 countries in Brazil, exclusively the data from the state of São Paulo, were considered, it was verified that the greater prevalence in the last 12 months was registered in Brazil with 10.4% and the lowest in Japan, with 2.2% [14]. The presence of depressive symptoms in cancer patients is associated with the worse perception of the health, greater levels of pain, worse quality of life, lower survival, greater risk of death, among others [15]-[18]. These factors could become chronical or recurrent and take the patient to substantial losses in the capacity of caring for his own daily responsibilities, as in the case of isolation, resulting in work leave [19] [20]. "

    Full-text · Article · Jan 2016 · Open Journal of Medical Psychology
  • Source
    • "Biopsychosocial models now highlight, however, that overall wellness must consider physical and mental health conjointly, with these elements being inextricably linked for both cancer patients and their caregivers. Patients expressing high levels of depressive symptoms (Hoppe et al., 2013; Pinquart & Duberstein, 2010; Satin, Linden, & Phillips, 2009) and stress (Chida, Hamer, Wardle, & Steptoe, 2008) have poorer physical health and treatment outcomes. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: Evidence suggests interdependence between cancer patients' and their caregivers' physical and mental health. However, the extent to which caregivers' health relates to their patients' recovery, or patients' health affects their caregivers' outcomes, is largely unknown. This dyadic investigation reports the relations between cancer patients' and their caregivers' physical and mental health trajectories during the year following diagnosis. Design: Ninety-two colorectal cancer patient-caregiver dyads completed questionnaires at two, six, and twelve months post-diagnosis. Outcome measures: Self-reported physical and mental health using the Medical Outcomes Study Short Form Health Survey-12. Results: Patients reported improved physical health over the year following their diagnosis, whereas caregivers reported declining physical health. Patients with lower mental health at diagnosis had stagnated physical health recovery. Caregivers' physical health declined most noticeably among those reporting low mental health at diagnosis and whose patients reported low physical health at diagnosis. Conclusion: Findings suggest targeting health interventions to cancer patients and caregivers reporting poor mental health at diagnosis may mitigate their long-term physical morbidity. Limited evidence of dyadic interdependence between patients' and caregivers' physical and mental health trajectories suggests future studies are warranted to identify psychosocial and medical characteristics moderating the relations between patients' and caregivers' health.
    Full-text · Article · Dec 2015 · Psychology & Health
  • Source
    • "Wassertheil-Smoller et al., 2004) or cancer (e.g. Pinquart and Duberstein, 2010). Specifically , increasing evidence suggests that the elevated risk for age-related disease in MDD may be due in part to an abnormal stress and immune response (e.g. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Leukocyte telomere length (LTL) is a marker of cellular turnover and oxidative stress. Studies suggest major depressive disorder (MDD) is associated with oxidative stress, but examinations of MDD and LTL have yielded mixed results, likely because of differences in measurement methods and unmeasured confounding. This study examined LTL and telomerase activity in 166 individuals with MDD compared to 166 age- and gender-matched matched controls free of any psychiatric disorder, using well-validated assays and clinical assessment methods, and controlling for a range of potential confounders. Subjects aged 18 to 70 were evaluated by trained raters and provided blood for LTL and telomerase activity measurement. LTL was assayed using Southern blot and replicated with qPCR, and telomerase activity was assayed with a repeat amplification protocol using a commercial kit. There was no significant difference in telomere length for individuals with MDD [mean (SD)=9.1 (3.0)kbp] compared to controls [mean(SD)=8.9(2.5)kbp] measured by Southern blot (p=0.65) or by confirmatory qPCR (p=0.91) assays. Controlling for potential confounders did not alter the results. Telomerase activity did not differ by MDD diagnosis overall (p=0.40), but the effect of MDD was significantly modified by gender (t(299)=2.67, p=0.0079) even after controlling for potential confounders, with telomerase activity significantly greater only in males with MDD versus controls. Our well-characterized, well-powered examination of concurrently assessed telomere length and telomerase activity in individuals with clinically significant, chronic MDD and matched controls failed to provide strong evidence of an association of MDD with shorter LTL, while telomerase activity was lower in men with MDD. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Full-text · Article · Apr 2015 · Psychoneuroendocrinology
Show more