Article

Rose, M.F., Ahmad, K.A., Thaller, C. & Zoghbi, H.Y. Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc. Natl. Acad. Sci. USA 106, 22462-22467

Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.
Proceedings of the National Academy of Sciences (Impact Factor: 9.67). 12/2009; 106(52):22462-7. DOI: 10.1073/pnas.0911579106
Source: PubMed

ABSTRACT

Hindbrain networks important for sensation and arousal contain diverse neuronal populations with distinct projections, yet share specific characteristics such as neurotransmitter expression. The relationship between the function of these neurons, their developmental origin, and the timing of their migration remains unclear. Mice lacking the proneural transcription factor Math1 (Atoh1) lose neurons essential for hearing, balance, and unconscious proprioception. By using a new, inducible Math1(Cre*PR) allele, we found that Math1 is also required for the conscious proprioceptive system, including excitatory projection neurons of the dorsal column nuclei and for vital components of the interoceptive system, such as Barrington's nucleus, that is closely associated with arousal. In addition to specific networks, Math1 lineages shared specific neurotransmitter expression, including glutamate, acetylcholine, somatostatin, corticotropin releasing hormone, and nitric oxide. These findings identify twenty novel Math1 lineages and indicate that the Math1 network functions partly as an interface for conscious (early-born) and unconscious (late-born) proprioceptive inputs to the cortex and cerebellum, respectively. In addition, these data provide previously unsuspected genetic and developmental links between proprioception, interoception, hearing, and arousal.

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Available from: Matthew F. Rose, May 30, 2014
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    • "Potential functional divisions within the SOC GABAergic and glycinergic systems are less clear. This situation contrasts with the finding that all SOC glutamatergic neurons derive from the Atoh1 lineage (Maricich et al., 2009; Rose et al., 2009 ), and that expression of Atoh1 and Ptf1a parse cochlear nucleus neurons into glutamatergic and GABAergic/glycinergic populations (Hoshino et al., 2005). Given that Atoh1 and Ptf1a are both basic helix-loop-helix (bHLH) transcription factors, it is possible that an as yet unidentified bHLH protein lies upstream of En1 and plays a similar role in inhibitory SOC neurons. "
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    • "The DNLL originates primarily in the isthmic Atoh1 + lineage (Wang et al. 2005; Rose et al. 2009; Machold and Fishell 2005) (Fig. 2). The INLL is derived from the alar plate of r1 (Moreno-Bravo et al. 2014) and the VNLL from r4 (Fig. 2) (Di Bonito et al. 2013b). "
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    • "Development (2014) 141, 4031-4041 doi:10.1242/dev.106559 DEVELOPMENT that migrate into ventral and isthmic r1 (Machold and Fishell, 2005; Wang et al., 2005; Green et al., 2014), contributing cells to multiple nuclei that form part of a wider hindbrain network of nuclei controlling proprioception, interoception and arousal (Rose et al., 2009). "
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