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Traditional medicinal uses of Hibiscus rosa-sinensis
Abstract
Medicinal and Aromatic Plants ( MAPS ) are the ingredients of herbal drugs, herbal preparations, and herbal medicinal products, besides traditional/ complementary medicines, house hold remedies and nutraceuticals. Over 100 million women world wide are currently using hormonal contraceptives. Hibiscus rosa-sinensis with these drugs, fertility can be suppressed at will, for as long as desired, with almost 100% confidence and complete return of fertility on discontinuation. The efficacy, convenience, low cost and overall safety of oral contraceptives ( OCS ) has allowed women to decide if and when they will become pregnant and to plan their activities. This article highlights some of the traditional medicinal uses, chemical composition, therapeutic evaluation of Hibiscus rosa-sinensis.
... A member of the Malvaceae family, Hibiscus rosa sinensis Linn is a glabrous shrub widely cultivated in the tropics as an ornamental plant with a variety of flower shapes and colors [13]. The various parts of this plant have been reported to have various medicinal properties (hypoglicaemic, antitumour, antioxidant, antihypertensive, antipyretic, anti-inflammatory, analgesic, anti-bacterial, menstrual cycle regulator, contraceptive, etc.) [14,15,16,17,18], justifying its use by natural health practitioners [13]. ...
... A member of the Malvaceae family, Hibiscus rosa sinensis Linn is a glabrous shrub widely cultivated in the tropics as an ornamental plant with a variety of flower shapes and colors [13]. The various parts of this plant have been reported to have various medicinal properties (hypoglicaemic, antitumour, antioxidant, antihypertensive, antipyretic, anti-inflammatory, analgesic, anti-bacterial, menstrual cycle regulator, contraceptive, etc.) [14,15,16,17,18], justifying its use by natural health practitioners [13]. Flavonoids, tannins, terpenoids, saponins and alkaloids are the main phytochemical compounds present in various extracts from the leaves, seeds, bark and stem of Hibiscus rosasinensis and are most likely responsible for their biological activities [19]. ...
... The flavonoids contained in H. rosa-sinensis extracts have been shown to induce anti-implantation and antispermatogenic effects in animals [20,21,22,23]. Several authors have demonstrated the antifertility, anti-spermatogenic, anti-oestrogenic and abortifacient activities of extracts of different parts of the H. rosa-sinensis plant [24,21,13,25]. Vasudeva and Sharma [26] reported post-coital activity of ethereal extract of H. rosa-sinensis roots administered orally to female colony-bred albino rats (Wister strain) and adult albino mice. ...
Aims: The purpose of this study was to explore the possible use of Hibiscus rosa sinensis leaf powder as a reproductive inhibitor in Oreochromis niloticus Place and Duration of Study: From 10th February to 21st June 2021 at the Kanhé-Moyo Integrated Fisheries and Aquaculture Research and Application Farm located in the locality of Baho'o belonging to the Baham District,in the West Region of Cameroon Study Design: 720 Oreochromis niloticus fingerlings with an average weight of 13±2.5g were randomly distributed in 12 happas arranged in an earthen pond measuring approximately 10 x 20 m and fed 3 experimental diets, formulated from a control diet to contain Hibiscus rosa sinensis leaf powder at doses of 3.5, 4.5 and 5.5 g/kg of feed respectively. Methodology: After 45 days post-treatment, survival and zootechnical growth parameters were assessed. Histological examination of the gonads was used to determine the impact of treatment on gonadal development at 45 and 65 days post-treatment respectively. Results: The results show that the different treatments had a similar effect on survival (P˃0.05), with an average value of 97.91 ± 3.81%. Analysis of the growth parameters of fishes from the different batches treated with different doses of H. rosa sinensis leaf powder revealed that the dose of 4.5 g/kg of H. rosa sinensis had a significantly greater effect than the other treatments applied in terms of Mean Final Weight (with a mean value of 24.77±0.27g), Mean Weight Gain (with a mean value of 3.63±1.18 g), mean specific growth rate (with a mean value of 1.13 ± 0.40%/day) and Mean Daily Gain (with a mean value of 0.25±0.08 g/d). However, analysis of the gonado somatic index at 45 and 60 days post-treatment of batches treated with different doses of H. rosa sinensis leaves revealed a significantly higher effect of the 3.5 g/kg dose on the gonado somatic index in both males and females. Observation of the testicular structures of the males from the treated batches revealed alterations reflecting an inhibition of gonadal development, which justifies the low gonado somatic index values observed in these different treated batches compared with the control batches. These alterations were also observed in the ovarian tissues of the treated females both at 45 and 60 days post-treatment. However, observations of the gonadal structures of satellite males and females at 60 days post-treatment revealed partial restoration of gonadal tissue in both males and females. Conclusion: The results of this study indicate that Hibiscus rosa sinensis leaves could be used as an alternative ecological method for inhibiting reproduction in Oreochromis niloticus. The results will help local producer networks to improve tilapia production.
... The chemical characterization and nutritional value of the Hibiscus rosa-sinensis forage were also described based on its age and production conditions, which demonstrated its similarity with the chemical and nutritional composition of other quality protein forages, for which 26 references were used [1,. Likewise, a detailed characterization of the secondary metabolites of the Hibiscus rosa-sinensis forage was carried out using 15 bibliographic references [8][9][10][11][12][13][14][31][32][33][34][35][36][37][38], which demonstrated the high content of various secondary metabolites within the phenolic compounds and alkaloids groups, confirming the pharmacological properties identified in this forage through 31 bibliographic references [2,8,14,32,33,37,. ...
... The main secondary metabolites of Hibiscus rosa-sinensis according to Jadha et al. [31] are flavonoids (cyaniding-3-sophoroside-5-glucoside, kaempferol-3xylosylglucoside, cyaniding-3,5diglucoside, quercetin-3-sophorotrioside, quercetin-3,7-diglucoside, quercetin-3-diglucoside) with recognized antioxidant and pharmacological properties [31,32]. ...
... The main secondary metabolites of Hibiscus rosa-sinensis according to Jadha et al. [31] are flavonoids (cyaniding-3-sophoroside-5-glucoside, kaempferol-3xylosylglucoside, cyaniding-3,5diglucoside, quercetin-3-sophorotrioside, quercetin-3,7-diglucoside, quercetin-3-diglucoside) with recognized antioxidant and pharmacological properties [31,32]. ...
This review summarized for the first time the nutritional benefits of Hibiscus rosa-sinensis in animal feed. the agronomic characteristics for the hyperproduction of Hibiscus rosa-sinensis were reported, as well as the chemical composition of the forage meal (leaves + petioles + stems), with emphasis on crude protein, amino acids, minerals, neutral detergent fiber, acid detergent fiber, lignin detergent acid, secondary metabolites, and metabolizable energy for ruminants and non-ruminants. Additionally, their medicinal properties such as antimicrobial, antifungal, antiparasitic, antioxidant, anti-inflammatory, antidiarrheal, and antipyretic properties were detailed. Its use as a source of protein in ruminant feeding is attractive and can be combined with grasses. In rabbits, fresh forage in high concentrations in the diets reduces the feed palatability, which causes a decrease in animal response, although it depends on the forage quality. In addition, limits for Hibiscus rosa-sinensis forage were recommended in diets or feeding systems for poultry, pigs, rabbits, goats, and sheep.
... Kembang sepatu juga dikenal sebagai mawar cina yang telah dibudidayakan secara luas di daerah tropis sebagai tanaman hias dan mempunyai beraneka ragam warna bunga, namun yang paling disukai untuk pengobatan adalah bunga yang berwarna merah (Jadhav et al., 2009). Tumbuh dari dataran rendah sampai pegunungan (Lestari, 2011). ...
... Hasil uji fitokimia menunjukkan dalam daun dan bunga kembang sepatu mengandung flavonoid, tannin, saponin dan steroid . Pada bunganya mengandung flavonoid, antosianin (Jadhav et al., 2009), polifenol (Lestari, 2011) dan akar mengandung tannin, saponin, skopoletin, cleomiscosin A dan cleomiscosin C (Lestari, 2011). ...
... Masyarakat suku Saling, di Desa Taba, Kecamatan Tebing Tinggi, Kabupaten Empat Lawang, Provinsi Sumatera Selatan memanfaatkan daun kembang sepatu untuk pengobatan liver, lambung dan maag . Hal ini juga dikuatkan dengan hasil penelitian Jadhav et al. (2009) yang menunjukkan bahwa daun dan bunga kembang sepatu efektif untuk mengobati penyakit maag, sedangkan bunganya efektif untuk mengobati hipertensi dan kolesterol. Hasil studi secara klinis menunjukkan bahwa obat siddha yang bahan bakunya dari bunga kembang sepatu efektif menurunkan kadar kolesterol, fosfolipid dan trigliserida pada darah 30 pasien yang menderita hipertensi dan kolesterol. ...
Indonesia merupakan negara dengan keanekaragaman yang sangat tinggi. Tidak hanya pada keanekaragaman hayatinya saja, melainkan juga pada keanekaragaman etnis dan budaya, termasuk tradisi dalam penggunaan tumbuhan berkhasiat obat sebagai bagian dari pengobatan tradisional. Badan Pusat Statistik 2010 merinci terdapat 1.340 etnis di Indonesia yang masing-masing memiliki pengetahuan tentang pengobatan tradisional menggunakan tumbuhan berkhasiat obat. Oleh karena itu, tidak mengherankan jika tumbuhan berkhasiat obat yang dikenal sangat banyak jenisnya. Departemen Kesehatan Republik Indonesia dalam Kebijakan Obat Tradisional Indonesia tahun 2006 menyatakan bahwa terdapat sekitar 30.000 jenis tumbuhan yang terdapat di Indonesia, tidak kurang dari 9.600 jenis memiliki khasiat obat, namun hasil penelitian Turjaman (2015) menyebutkan baru sekitar 1.200 jenis tumbuhan obat yang telah digunakan dan diteliti sebagai obat tradisional, tetapi risetnya belum maksimal. Sedangkan Badan Pengawas Obat dan Makanan (BPOM) menyebutkan jumlah jenis tumbuhan yang sudah didaftarkan untuk penggunaan obat tradisional atau jamu berkisar 283 jenis tanaman dan 180 jenis di antaranya diperoleh dari hutan, 30% diantaranya sudah dibudidayakan, dan sisanya dipanen langsung dari alam. Tumbuhan berkhasiat obat merupakan tumbuhan yang memiliki senyawa yang bermanfaat untuk mencegah dan menyembuhkan penyakit, melakukan fungsi biologis tertentu, hingga mencegah serangan serangga dan jamur. Tumbuhan obat dapat berupa tumbuhan pangan, tumbuhan hortikultura maupun tumbuhan liar seperti semak belukar dan tumbuhan hutan. Badan Pusat Statistik tahun 2018 merilis data bahwa presentasi penduduk Indonesia yang mempunyai keluhan sakit adalah sebesar 28,62% dan dari jumlah tersebut ternyata 69,43% nya memilih untuk melakukan pengobatan sendiri. Salah satu penyebabnya adalah melonjaknya harga obat sintetis dan resiko efek sampingnya bagi kesehatan, sehingga masyarakat lebih memilih gaya hidup kembali ke alam (back to nature) dan cenderung menggunakan tumbuhan berkhasiat obat. Pengetahuan tentang jenis, tata cara penggunaan, manfaat serta kandungan farmakologi tumbuhan berkhasiat obat sangat berguna dalam pengembangan obat baru. Kehati (2017) menyebutkan 11% dari 252 senyawa obat yang oleh World Health Organization (WHO) dinyatakan sebagai senyawa obat dasar dan esensil, berasal dari tumbuhan berbunga. Bahkan sampai saat ini pun banyak senyawa-senyawa obat yang digunakan dalam pengobatan modern yang berasal dari tumbuhan dan berakar dari
... Traditionally the leaves and flowers are observed to be promoters of hair growth and aid in healing of ulcers. Flowers have been found to be effective in the treatment of arterial hypertension and to have significant antifertility effect [119] . Pharmacologically reported activities are anti-spermatogenic and androgenic [120] antitumor [121] , anticonvulsant [122] , anti-diabetic [123] , antiulcer [124] and hair growth promoter [125] . ...
... Pharmacologically reported activities are anti-spermatogenic and androgenic [120] antitumor [121] , anticonvulsant [122] , anti-diabetic [123] , antiulcer [124] and hair growth promoter [125] . Phytochemical constituents in this plant are anthocyanins and flavonoids, cyanidin-3,5-diglucoside, cyanidin-3-sophoroside-5-glucoside, quercetin-3,7-diglucoside, quercetin-3-diglucoside, a cyclopeptide alkaloid, cyanidin chloride, quercetin, hentriacontane and vitamins: riboflavin, ascorbic acid and thiamine have been reported [119] . ...
... In the past, different parts of the Hibiscus rosa sinensis plant were used to make traditional medicines (Jadhav et al 2009), such as antibacterial, antioxidant, and wound-healing medicines. Most people currently use natural products or biopolymeric materials for health care, such as sodium alginate hydrogel (Bahadoran et al 2020), carbopol, hyaluronic acid, chitosan, silk fibroin, xanthan gum, gum acacia, etc. Biopolymer also has certain advantages such as being biocompatible, biodegradable, well available, nonirritant in nature, cost-effective, and lastly, antimicrobial and anti-inflammatory properties making them an ideal component of wound healing (Jani et al 2009, Saha et al 2023. ...
... In the past, different parts of the Hibiscus rosa sinensis plant were used to make traditional medicines (Jadhav et al 2009), such as antibacterial, antioxidant, and wound-healing medicines. Most people currently use natural products or biopolymeric materials for health care, such as sodium alginate hydrogel (Bahadoran et al 2020), carbopol, hyaluronic acid, chitosan, silk fibroin, xanthan gum, gum acacia, etc. Biopolymer also has certain advantages such as being biocompatible, biodegradable, well available, nonirritant in nature, cost-effective, and lastly, antimicrobial and anti-inflammatory properties making them an ideal component of wound healing (Jani et al 2009, Saha et al 2023. ...
Mucilage is a sticky substance found in various plants and microorganisms and is made up of proteins and polysaccharides. Mucilage from Hibiscus rosa sinensisis is a complex polysaccharide traditionally used to treat different skin diseases. In our study, we fabricated mucilage polymer from Hibiscus rosa sinensis leaves and evaluated its potential application in second-degree burns and excision wounds. The physical properties of Hibiscus mucilage (HM) polymer were demonstrated by using ultraviolet-visible absorption spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, Dynamic light scattering, Scanning electron microscopy, Brunauer–Emmett–Tellerand, Swelling ratio. The human cell lines WI-38, and HaCaT have been used for in-vitro experiments like MTT, Scratch wound, BrdU, ROS scavenging assays, and western blot analysis. The results of the MTT, scratch-wound, and BrdU assay indicated that the HM polymer is nontoxic in nature and also enhances both the properties of cellular migration and proliferation, respectively. On the other hand, the result of the ROS scavenging assay suggested that HM polymer enhances the antioxidant activity of cells while the western blot analysis designated, that the HM polymer treatment caused down regulation of pro-inflammatory cytokine IFN-γ and upregulation of pAkt (Serine 473) protein, and TGF-β1 signaling pathway. Therefore, all in-vitro experiments studies recommended that HM polymer is biocompatible and has antioxidant and anti-inflammatory effects. In the in vivo experiment, second-degree burns and excision wounds were created on the dorsal surface of male BALB/c mice. After the sixth day of HM polymer treatment have developed new tissue, hair follicles, blood vessels, α-SMA, and Collagen type-1 fiber on the burn and excision wound area while the 11th day of HM polymer treatment cured the wound area significantly. Therefore, it could be contemplated that HM polymer is a potential agent for treating different wounds in the near future.
... Swiss mice weighing b/w 60-80g were divided into 4 groups each containing 6 animals- [21]. ...
Anxiety is a medical condition related to our psychological as well as physiological behavior having numerous characters like cognitive, emotional, behavioral, and somatic. The present study was based on a comparative phytochemical and anxiolytic screening of ethanolic extracts of leaves and flowers of Hibiscus rosa sinensis. Soxhlet extraction was done for flowers and leaves of Hibiscus rosa sinensis using solvent like ethanol at 60°C for 48hr. Phytochemical screening was performed for both the extracts and flavonoids was isolated utilizing TLC, Column chromatography and UV and FTIR spectrophotometry. Elevated plus maze and light/dark arena models were used for the pharmacological screening. In results, the percentage yield of Ethanolic flower and leaves extract of Hibiscus rosa sinensis were reported 2.98% & 8.3%, respectively. ethanolic leaves extracts of Hibiscus rosa sinensis showed an excellent anxiolytic activity in comparison to the flower extract of hibiscus rosa sinensis in both the models used-elevated plus maze and light/dark arena model. For flower, in elevated plus maze no. of entries in open arm of HFE (200mg/kg) was 5.26±0.68 and HFE (400mg/kg)7.36±0.72 and time spent in open arm area of HFE (200mg/kg) was 67.30±0.78 and HFE (400mg/kg) was 75.80±0.71 and in light/dark arena model no. of entries in light arena HFE (200mg/kg) was 5.13±0.43 and HFE (400mg/kg) was 7.19±0.58 and time spent in light arena HFE (200mg/kg) was 64.28±0.63 and HLE (400mg/kg) was 77.47±0.81 and for leaf, elevated plus maze in no. of entries in open arm HLE (200mg/kg) at 5.43±0.48 and HLE (400mg/kg) 7.56±0.76 and time spent in open arm area HLE (200mg/kg) at 74.30±0.60 and HLE (400mg/kg) at 76.50±0.81 and in light/dark arena model no. of entries in light arena HLE (200mg/kg) at 5.41±0.63 and HLE (400mg/kg) at 7.46±0.74 and time spent in light arena HLE (200mg/kg) at 65.27±0.18 and HLE (400mg/kg) at 81.30±0.43 were reported. In conclusion, ethanolic leaves extract of Hibiscus rosa sinensis has higher content of flavonoids and is an important herbal anxiolytic medication.
... [1][2][3][4][5][6]. Hibiscus flowers and leaves are used in India for the abortion, antifertility, contraceptive, Diuretic, Menorrhagia, Bronchitis, Emmengogue, emulcent, and Cough" [7]. Methanol and ethanol extracts of the plant have been reported for antioxidant activity" [8][9][10][11][12][13][14]. ...
We have undertaken to study the pharmacological activities of the hydro-methanolic leaves extract of Hibiscus rosa sinesis using standard screening methods such as disc diffusion and DPPH methods. In phytochemical screening, Secondary metabolites such as phenols, saponins, and tannins were present in. Hibiscus rosa sinesis leaf extract. The dose dependent antibacterial and antioxidant activities was also observed. The present study is important because Hibiscus Rosa sinensis plant is important in traditional medicine to cure various ailments.
... Various parts of plant are used in urinary complaints and in hysteria. In Samoa roots and others parts are taken as remedies for gonorrhea, vomiting of blood and in stomach trouble" [9,10,[77][78][79][80]. ...
Endophytes were first reported by the Freeman (1904) from dunel grass. 3,00,000 plant species known which exist on earth, all are host to one or more endophytes [1]. Endophytes are found in roots, leaves, stems, fruits, tubers, ovules etc. (Hallmann et al., 1997; Sturzet al., 1997: Hurek et al., 2002, Benhizia et al., 2004; Iniguez et al., 2004). Many different types of alkaloids, terpenoids, flavonoids and steroids are produced by endophytic fungi and these metabolites of endophytic fungi have antimicrobial, antiviral, anticancer, and antioxidant potential. The root of the Hibiscus rosa is used for cough treatment. The leaves of the H. rosa are used as a laxative and flowers has anti-diarrhea properties and are considered as demulcent, emollient, refrigerant, aphrodisiac and emmenagogue. The high level of antioxidants in H. rosa sinensis can slow down the aging process by eliminating the free radicals and neutralizing their harmful effects on the cells of human body. Hibiscus flowers are used as a remedy for relieving respiratory problem and to improve the health of respiratory system. This work reveals that the endophytic bacteria and fungi were isolated from healthy leaves and stem of medicinal plant, H. rosa-sinensis which were first sterilized in 70% ethanol. The bacterial endophytes were isolated on Nutrient Agar Medium and fungal endophytes were isolated on Potato Dextrose Agar Medium. Colonies showing similar morphology on one plate were considered as single colony and so the frequency of each colony is calculated and isolated in pure form. By pure culture isolation technique, 4 different isolates of bacterial endophytes and 2 different isolates of fungal endophytes from stem of H. rosa-sinensis and 3 different isolates of fungal endophytes from leaves of H. rosa-sinensis were obtained. Bacterial endophytes were identified on the basis of Gram Stain and biochemical characterization whereas the identification of fungal endophytes was carried out at Plant Pathology Department of Forest Research Institute (FRI), Dehradun. The secondary metabolites were isolated from isolated bacterial and fungal endophytes by using two different solvents (Ethyl acetate, chloroform) in the ratio 1:1 left for 15 minutes, the organic phase were collected and kept for drying at 37C. The antimicrobial activities were done against human pathogen (Stayphylococcus aureus and Klebsiella pneumonia) by using Disc diffusion method of isolated secondary metabolites.
... In a research study, Yashaswini et al. (2011) found that on a dry weight basis, 100 gram (g) of Hibiscus flowers contain 353 calories, 3.9 gm of protein, 3.9 gm of fat, 86.3 gm of carbohydrate, 15.7 gm of fibre, minerals like 39 mg of calcium, 265 mg of phosphorus, 1.7 mg iron, and different vitamins such as 5.9 mg of niacin, 3.9 mg ascorbic acid, 0.49 mg riboflavin (B2), 0.29 mg thiamine (B1) and 5.9 mg ash. In India, the flowers and leaves of this plant are used for emmenagogues, antifertility, contraceptives, menorrhagia, diuretics, bronchitis, cough, and menorrhagia (Jadhav et al., 2009). ...
... 2 Red flowered is normally used and preferred as medicinal agents. 3 It is originated from India and some claim that Hibiscus rosa-sinensis is not a natural herb, however it is a collection of man-made hybrids. 4 Hibiscus rosa-sinensis was previously known as 'rose mallow' or 'Queen of Tropical Flower' and in Malaysia it is called 'Bunga Raya' . ...
... The flower has been used in diabetes, leprosy, regulating the menstrual cycle, liver ailments, stomachaches, cough suppressant, eye problems, miscarriage problems, and as an aphrodisiac. The leaves are used in the treatment of headache, dysentery, diarrhea, arthritis, boils and cough (Chopra and Rashid 1969;Jadhav et al. 2009;Pekamwar et al. 2013;Nath and Yaday 2015). Phytochemical analysis showed that H. rosasinensis leaf extract is rich in protein, free amino acids, carbohydrates, steroids and essential oils as well as phenolic compounds (Divya et al. 2013). ...
Harmful rays coming from the sun cause negative effects on the human body. Sunscreens and UV protective products are used to reduce and prevent these negative effects. Plants have been used in medicine and cosmetics for centuries, and have the potential to treat skin diseases. Consumers tend to use sunscreens that contain natural ingredients instead of synthetic sunscreens. In this study, the in vitro solar protection factor (SPF) values of water extracts from flowers and leaves of Hibiscus rosa-sinensis were investigated. In addition, the SPF values of the water extracts and commercially available cream mixtures were also examined. The SPF values of the extracts were measured at the wavelengths of 290-320 nm of UV-B ultraviolet rays reaching the earth from the sun. SPF values of H. rosa-sinensis flower and leaf extracts were determined as 11.77 and 22.10. The leaf extract has the highest SPF value (21.70) in 10 mL concentration among the prepared extract and cream mixtures. Therefore, H. rosa-sinensis extracts with high SPF values may have the potential to be used as natural additives in the cosmetic industries.
... Some studies suggested that it contains tannins, flavonoids, steroids, alkaloids, saponins, otal phenol, total flavonoids, etc. In India, it is used as anti-fertility, contraceptive, diuretic, menorrhagia, emmengogue, demulcent, bronchitis, and cough [23]. ...
Nanoparticles are considered as most immerging subject in the field of medicines. There are several types of nanoparticles. Silver nanoparticles have been deeply examined due to their exclusive properties such as conductivity, chemical stability, catalytic activity, nonlinear optical behavior, and bactericidal activity. Silver nanoparticles is always been a trendy topic in pharmaceutical revolutions and various other fields. Also, green synthesis of silver nanoparticles has become new and promising field of research in current years. There are several merits of green synthesis as it is a simple approach towards research, also it is eco friendly and cost friendly approach. As we all know how silver is used since ancient times for its antimicrobial activities. So, in this project we have aimed on antimicrobial activity of silver nanoparticles along with ceftriaxone which is also a good anti-microbial agent.
... Roots of the plant have been known to show laxative and aphrodisiac properties 18 . Decoction of roots and leaves is used to cure arthritis, cough, and boils 19 . Leaves are also used for the treatment of dysentery, and diarrhea and to promote the draining of abscesses 20 . ...
This study aimed to investigate the chemical composition, antioxidant and synergistic antimicrobial potential of Hibiscus rosa-sinensis L. (China rose) leaves essential oil and its major compound, Dioctyl phthalate (DOP). The essential oil was extracted from leaves by hydro-distillation using the Clevenger apparatus. The essential oil was characterized by Gas Chromatography-Mass Spectrometry (GC/MS) analysis which revealed the presence of DOP as a major compound. The essential oil and DOP were tested for antibacterial activity against Klebsiella sp. and Pseudomonas aeruginosa using the disc plate method, antifungal activity against Fusarium oxysporum by agar well diffusion method, and antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radical scavenging assays. The synergistic antimicrobial interaction of essential oil and DOP was also tested against standard antimicrobials: tetracycline, chloramphenicol, fluconazole, and clotrimazole. The maximum antimicrobial potential was exhibited by China rose leaves essential oil with minimum inhibitory concentrations (MIC) of 18.5, 11.5, and 23.0 μg/mL against Klebsiella sp., P. aeruginosa, and F. oxysporum respectively. Moreover, the essential oil exhibited synergistic interaction with standard antimicrobials with a 3.75 to 10 times decrease in their MIC values. The essential oil also exhibited median inhibitory concentration (IC50) values of 780, 800, and 860 μg/mL in DPPH, NO, and ABTS free radical scavenging assays respectively. Hence it can be concluded that China rose leaves essential oil has a huge significance in pharmaceutical industries as an alternative to synthetic antioxidants and antimicrobials in near future.
... Hibiscus rosa-sinensis (HRS) is a member of the family Malvaceae. It is known by many other names, such as rose mallow, China rose, musk mallow rose of Sharon and sour tea [12][13][14]. There are about 300 species in the family Malvaceae, found across the tropical region of the world, including in North Africa, China, Japan, Malaysia and Thailand [15,16]. ...
The administration of drugs into the body is essential for the treatment of diseases. However, drugs need to reach the targeted site to be effective. Excipients such as polymers are used in drug formulations to ensure that drugs exert their therapeutic effects. Recently, plant-based polymers have been extensively explored in pharmaceutical research. These polymers, including gums and mucilages, are investigated for their roles in various pharmaceutical applications. The plant-based polymers have advantages compared to synthetic polymers due to their bioavailability, chemical inertness, non-toxicity and wide availability. When gums or mucilages are combined with other polymers, their final properties improve. In some instances, the characteristics of gums and mucilages such as swelling, flow and mucoadhesive properties are better than the abilities of synthetic materials. This article reviews the use of Hibiscus rosa-sinensis (HRS) mucilage as an excipient in several dosage forms to enhance drug delivery systems. Their physicochemical properties and mechanisms of action are also discussed. The review ends with a discussion of the limitations and future prospects of HRS mucilage in pharmaceutical applications.
... The plant extract was obtained from Hibiscus Sabdariffa. Before this experiment, it is widely known that the hibiscus extract are used for flavours, medicinal, pharmaceuticals, agrochemicals, fragrances, and local dyes [14][15][16]. The major component in the flower is the cyanidin 3-sophoroside. ...
This research focuses on ways to protect the photovoltaic solar panel from harmful radiation during harsh weather conditions. The bio-filter made up of copper coated hibiscus extract from methanol was proposed. It was discovered that the bio-filter was able stabilize the fluctuations and in some cases improved on the output of the PV panel. It was recommended that the onward study on this kind of bio-filter would enhance higher patronage of PV products in the African market.
... The bioactive compounds found in crude plant extracts make it suitable for a broad range of medicinal properties like anti-diabetic, antiproliferative, anti-inflammatory, anti-obesity, nephroprotective, anti-ulcer, hepatoprotective, hypersensitive, and hypolipidemic. 9 Indubitably, the existence of apparent biologically active compounds like tannins, flavonoids, saponins, carbohydrates, steroids, phenols, glycosides, quinones,terpenoids, cyclopeptide alkaloids, vitamins and flavonoids, has been increasingly reported with enormous prospective in modern therapeutic uses. Hereof, this review explores the pertinent data on biological elucidation, Phytochemistry, ethnomedicinal uses, pharmacological activity, antioxidant activities and pernicious, in addition to the preservation of Hibiscus Rosa Sinensis. ...
Hibiscus Rosa Sinensis Linn. (Malvaceae) is a popular medicinal plant found in tropical and sub-tropical region of world. All plant parts of Hibiscus Rosa Sinensis Linn are most widely used to treat several ailments like anti-Tumor, anti-fertility, anti-ovultory, anti-implantation, anti-Inflammatory, analgesic, anti-estrogenic, anti-pyretic, anti-spasmodic, anti-viral, anti-fungal, anti-bacterial, hypoglycemic, spasmolytic, CNS depressant, hypertensive and juvenoid Activity. Due to its multidimensional pharmacological approach it is certain to emerge as a effficient player in the flourising field of herbal supplements, medicines and health care system. This review aims to present recent details on botany, ethnomedicinal uses, photochemistry, pharmacological effects, toxic effects, with the purpose to find research gaps demanding for upcoming research and investigation of Hibiscus Rosa Sinensis Linn. Principal constituents reported in Hibiscus Rosa Sinensis Linn are flavones, containing quercetin-3-sophorotrioside, kaempferol-3xylosylglucoside,quercetin-3-diglucoside, quercetin-3,7-diglucoside, cyaniding-3,5-diglucoside, cyaniding-3-sophoroside-5-glucoside and other constituent are cyanidin chloride, cyclopeptide alkaloid, ascorbic acid, riboflavin, thiamine, hentriacontane, taraxeryl acetate, ß-sitosterol, malvalic acids and cyclic acids sterculic. Complete literature was probed via websites,online databases, thesis and texts. The available reports was portray physicochemical parameters, nutritional aspects and phytochemical analysis of bioactive plant parts. Friendly holistic conservation approaches offered by plant biotechnology applications are also discussed.
... It is a potential source of many bioactive natural products, which are used in folk medicinal system, especially for curing liver disorders and hypertension (Yasmin, 2010). Moreover, Jadhav et al. (2009) stated that more than 100 million women worldwide are using H. rosa-sinensis with contraception's to suppress fertility with almost 100% confidence and complete return to fertility at will. It is also used for regulation of the menstrual cycle, diuretic, antitussive, dysentery, amenorrhea and abortion. ...
This investigation was conducted under full sun conditions at the nursery of Hort. Res. Inst., A.R.C., Giza, Egypt during 2020 and 2021 seasons to examine the effect of salicylic acid (SA) as a foliar spray at concentrations of 0, 50, 75 and 100 ppm on growth, flowering and chemical composition of Hibiscus rosa-sinensis L. transplants grown in 16-cm-diameter plastic pots filled with about 1.6 kg of clay and subjected to four water treatments: 100% field capacity (F.C.) as control, 75, 50 and 25% of F.C. as water stress treatments. The effect of interactions between SA and water treatments was also studied. The results indicated that mean values of various vegetative and root growth parameters were progressively increased with increasing either water amount or SA concentration compared to the means of low levels of both, with few exceptions. Thus, the highest means of the different growth traits were attained by the highest levels of both water treatments (75 and 100% of F.C.) and SA ones (75 and 100 ppm) as well as their interactions, with the superiority of a combination between 75% of F.C. water treatment and SA spray at 75 ppm, giving almost the highest records. A similar trend was also obtained regarding flowering parameters and chemical composition of the leaves with the exception of chlorophyll a concentration that was slightly affected by the different treatments used in this study, and the percentages of P and K which were fluctuated, as well as proline concentration that was descendingly decreased with increasing either SA concentration or water quantity and their interactions. Thus, it can be recommended to spray Hibiscus rosa-sinensis L. plants with salicylic acid at 75 ppm, 3 times at 3-weeks intervals and irrigate them with only 75% of F.C. to save as much water as 25% of F.C. with keeping growth, flowering and quality of the plants.
... years. If once a kidney stone forms in any person then the probability of occurrence of stone in the body increase, the probability that a second stone will form within five to seven years is approximately 50% (2) . ...
The main objective of this study is to determine efficacy of Hibiscus rosa sinensis flowers hydro alcoholic extract used for dissolve Calcium oxalate stone by treating stones with different concentrations of extracts. UV Spectroscopy instrument were used to detected absorbance of light by the crystal in the present in the herbal extract in different concentration. Turbidity meter is the instrument which is used to determine the turbidity in the sample. As a result, this study data show hydro alcoholic extract of the hibiscus rosa sinensis show significant reduction in crystal size reduction 10% to 60% inhibition of crystal formation in the presence of different concentration 100 μg, 500 μg ,1000 μg. The studies data support significant inhibition of crystal formation using hydro alcoholic extract of hibiscus flower for vitro anti-urolithic activity. The formation of suitable dosage form and use on the animal models will be increase the chance of better results.
... (Malvaceae) is a shrub commonly found in the tropics of India. The plant is reported to possess hypoglycemic, cardioprotective, antitumor, anti-fertility, antiinflammatory, hair growth-promoting, and antioxidant properties [8]. It is broadly used as an ingredient in herbal teas; its beneficial effects are attributed to the antioxidant phenolic compounds. ...
Background: Hyperglycemia and oxidative stress are hallmarks of diabetes mellitus (DM). Excessive oxidative stress is implicated in diabetic pathogenesis when endogenous antioxidants are defective.Objective: The present study evaluates the effects of anthocyanins present in the petals of Hibiscus rosa- sinensis on oxidative stress and antioxidant status in streptozotocin-induced diabetic rats.Materials and methods: Diabetes was induced in male Sprague-Dawley rats by a single intraperitoneal injection (30mg/kg) of streptozotocin. Hibiscus rosa sinensis anthocyanins (HA) extract (50 mg/kg body weight) orally administered to diabetic rats for 30 days. Results compared with diabetic rats provided with the standard drug metformin (150 mg/kg body weight).Results: Altered levels of glucose, glycated hemoglobin, toxicity markers and lipid profile in serum were significantly modulated upon the administration of HA in diabetic rats. A supplementation of HA to diabetic rats reduced oxidative stress, as well as increased the levels of antioxidant enzymes in the liver. The present study demonstrates that HA has a protective effect on diabetic ratsConclusion: The present study indicates that Hibiscus anthocyanin supplementation could protect diabetic rats' livers by protecting the hepatocytes from oxidative stress and increasing the antioxidant enzymes' activity. Keywords: Diabetes mellitus, Hibiscus rosa sinensis anthocyanins, Oxidative stress
... This plant is a glabrous shrub cultivated as an ornamental plant. Among the different colors, red flowered variety is mostly used as a herbal remedy (Jadhav et al., 2009). Due to universal availability and good palatability, herbal home-made tea could be prepared with the petals of Hibiscus rosasinensis with a minimum preparation time. ...
According to traditional medicine, Hibiscus is used to treat hypertension, heart diseases and many other ailments. Commercially available Hibiscus tea is prepared with H. sabdariffa and is expensive. H. rosasinensis is the common variety which is abundant in tropical home-gardens, however the scientific data are lacking on the effects. The present review focuses on the available scientific data on the effects of H. rosasinensis on controlling diabetes and hypercholesterolemia. The endeavour was to identify whether H. rosasinensis flower petals as a ‘tea’ is effective for diabetic and hypercholesterolemic patients. Medical databases such as MEDLINE, BMC, BMJ, research gate, Mendelay literature search database, Google scholar and the general engine Google were searched from November 2018 to April 2019. Search was carried out using keywords such as “Hibiscus rosasinensis”, “antidiabetic effects”, “antihyperlipidemic effects”, “toxic effects”, “anti-inflammatory effects”, “phytochemicals in Hibiscus” etc. Data were critically analyzed to assess whether the effective doses of the research studies on a par with the doses present in H. rosasinensis teas. We found thirty-nine journal articles fulfilled the criteria. The data were categorized and extracted on uses of H. rosasinensis, anti-diabetic effects, anti-inflammatory effects, anti-hypercholesterolemic effects and its phytochemicals. The review revealed that the dose of H. rosasinensis petals present in a home-made Hibiscus tea is theoretically sufficient to elicit anti-hyperglycemic and anti-hyperlipidemic effects. Home-made Hibiscus tea is effective in controlling diabetes and hypercholesterolemia without causing acute toxicity.
... Kembang sepatu secara tradisional diyakini memiliki aktivitas dapat memacu pertumbuhan rambut yaitu bunga dan daun kembang sepatu (Hibiscus rosa-sinensis) (Kumar & Singh 2012;Pathan et al 2012). Daun dan bunga kembang sepatu kaya akan flavonoid, dimana komponen utama daun dan bunga kembang sepatu adalah antosianin dan flavonoid, sianidin-3,5-diglukosida, sianidin-3sophorosida-5-glukosida, kuersetin-3-7diglukosida, dan kuersetin-3-diglukosida (Jadhav et al. 2009). Hasil penelitian (Amelia et al. 2016) membuktikan bahwa ekstrak etanol daun kembang sepatu lebih poten merangsang pertumbuhan rambut dibandingkan dengan ekstrak etanol bunga kembang sepatu yang dibuat dalam sediaan hair tonik. ...
Kembang sepatu mengandung flavonoid, saponin dan polifenol yang berperan dalam mempercepat pertumbuhan rambut. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi ekstrak etanol daun kembang sepatu dalam sediaan creambath terhadap pertumbuhan rambut kelinci. Ekstrak etanol daun kembang sepatu diperoleh dengan metode remaserasi menggunakan etanol 70%. Sediaan creambath dibuat dalam 4 formula dengan konsentrasi ekstrak kembang sepatu sebanyak 10%, 15%, 20% dan kontrol negatif. Creambath diaplikasikan ke punggung kelinci yang telah dicukur kemudian diberi sediaan creambath 2 kali sehari selama 15 hari. Uji aktivitas pertumbuhan rambut kelinci dengan mengukur panjang rambut dan bobot rambut kelinci, serta dilakukan uji fisiknya yang meliputi bau, warna, pH, daya sebar, daya lekat, kemampuan proteksi, viskositas, tipe krim, dan stabilitas creambath. Data uji mutu fisik, bobot, dan rambut dianalisis dengan Saphiro-Wilk, kemudian menggunakan ANOVA dan Post Hoc Tests. Hasil penelitian menunjukkan bahwa sediaan creambath ekstrak etanol daun kembang sepatu dengan konsentrasi 10%, 15%, dan 20% memilki stabilitas fisik yang baik. Semakin tinggi konsentrasi ekstrak dalam sediaan creambath menghasilkan perbedaan aktivitas pertumbuhan rambut kelinci. Hasil dilihat dari parameter bobot dan panjang rambut, tetapi belum bisa seefektif kontrol pembanding. Formula creambath yang memberikan hasil efektif terhadap pertumbuhan rambut kelinci adalah creambath dengan konsentrasi 20%.
... Folk medicinal plants, particularly their extracts and phytochemicals, have been perceived as relatively safe with little or no side effects and often act at multiple and novel target sites, thereby reducing the risk of resistance development (4). A number of medicinal plant preparations traditionally used for treatment of topical wounds and gastrointestinal disorders have been reported to have anti-and also for regulation of menstruation and stimulation of blood circulation (7). Aerial part extracts of the plant have been known to possess antiulcerogenic activity on gastric ulcers (8). ...
Utilization of plant resources for treatment of Helicobacter pylori infections is one of the appealing approaches as rapid emergence of antibiotic-resistant strains is occurring throughout the world. Ethanol extract and its fractions from Hibiscus rosa-sinensis red flower were assessed for antibacterial and urease inhibitory activities towards forty-three clinical strains and two reference strains of H. pylori. The ethyl acetate fraction exhibited the most potent bacteriostatic activity with minimum inhibitory concentrations (MICs) of 0.2-0.25 mg/mL and minimum bactericidal concentrations (MBCs) of 1.25-1.5 mg/mL against all test strains, including forty-three strains resistant to one to four antibiotics, azithromycin (MICs, 8-256 µg/mL), erythromycin (MICs, 8-128 µg/mL), levofloxacin (MICs, 8-256 µg/mL), and/or metronidazole (MICs, 8-256 µg/mL). The fraction had similar antibacterial activities toward these test strains suggesting the preparation and the antibiotics do not have a common mechanism of anti-H. pylori activity. The fraction also had stronger effects on biofilm formation, morphological conversion, and urease activity of H. pylori than the other fractions and the ethanol extract. These flower preparations were non-toxic to three human cell lines, and nine compounds were also isolated and identified from the ethyl acetate fraction. In vivo research needs to be conducted to confirm the potential usefulness of H. rosa-sinensis flower and its constituents for effective prevention and treatment of H. pylori disease.
... Flowers were reported to be effective in hypertension treatment and possessed a good antifertility effect. 3 Furthermore, hibiscus acts as antioxidant, expectorant with mild laxative and diuretic effect. It was also found to decrease cholesterol levels. ...
... It acts as an antioxidant and helps in the reduction of cholesterol levels (Esa, 2010); as emollients and aperients to treat burning sensations, skin disease, and constipation (Kirtikar and Basu, 1999), and has anti inflammatory and astringent properties (Yazan et al., 2011). In India, flowers and leaves are used for the abortion, antifertility, contraceptive, diuretic, menorrhagia, bronchitis, emmengogue, demulcent and cough (Jadhav et al., 2009). Various parts of the plant are also used in the preparation of jams, spices, soups, and sauces (Baranova et al., 2011). ...
Survey conducted on Hibiscus rosa-sinensis Linn. growing in Karnataka revealed 20 species of insect pests. Of these, five species are new records.
... In particular, Hibiscus rosa sinensis L. (Malvaceae) is an evergreen shrub or small tree native to tropics and subtropics with varying colors of flowers, but the red flower variety is widely planted as a fence or hedge plant and used for medicine. 10 All parts of the plant have been traditionally used in folk medicine. The phytochemical constituents, pharmacological effects, and medicinal uses of H. rosa sinensis have been well described. ...
The aim of the present study was to assess antimicrobial effects of naringenin (NRG), luteolin (LUT), myricetin (MCT), and protocatechuic acid (PCA) identified in a Hibiscus rosa sinensis flower against two reference strains and five clinical isolates of Helicobacter pylori. NRG displayed the most growth inhibitory and bactericidal activities to seven bacterial strains including six strains resistant to one or several antibiotics, azithromycin (MIC, 16–32 mg/L), erythromycin (MIC, 32 mg/L), levofloxacin (MIC, 32 mg/L), and/or metronidazole (24–64 mg/L), followed by LUT and MCT, while PCA showed weak activities toward the strains. These constituents had similar antibacterial activities toward the seven tested strains suggesting that these constituents and the antibiotics do not have a common mechanism of anti-H. pylori activity. NRG, LUT, and MCT resulted in a high percentage of coccoid forms of H. pylori. NRG exhibited the highest anti-biofilm formation activity. MCT produced the strongest inhibition of urease activity followed by LUT and PCA, whereas the activity of NRG was similar to standard inhibitor thiourea. The four constituents had no significant toxicity to human cell lines. A global attempt to decrease utilization of antibiotics justifies the need for further research on H. rosa sinensis derived materials containing NRG, LUT, MCT, and PCA as potential products or lead compounds for the prevention or treatment of diseases caused by H. pylori infection.
... The plant extract was obtained from Hibiscus Sabdariffa as shown Figure 1. Before this experiment, it is widely known that the hibiscus extract are used for flavours, medicinal, pharmaceuticals, agrochemicals, fragrances, treatment of wastewaters and local dyes [12][13][14][15]. The major component in the flower is the cyanidin 3-sophoroside. ...
p>The challenges facing solar power grid system in Africa is huge. Most salient of these challenges is the inefficiency of the photovoltaic (PV) panel to sustain its output for more than a year. Certainly, the harsh weather condition in the region can be said to be one of the reasons for the shortcoming that was earlier highlighted. In this research, bio-filters were suggested to filter the harmful radiation hitting the PV panel. The bio-filter is made up of copper coated hibiscus extract. The hibiscus extract was done using ethanol solution. It was observed that the bio-filter was able to filter the some of the harmful radiation as expected. The quantity of the harmful solar radiation was not estimated because of the limitations of the equipment used for the research. It is recommended that this highlighted shortcoming of the research should be taken further to ascertain i.e. in percentage the harmful radiation that has been filtered by the bio-filter during the experiment.</p
... It has immense potential of hair growth and healing of ulcers [24,25]. The extensive study of the uses of Hibiscus plant for the various purposes in many countries was reported by the V.M. Jadhav et al. [26]. The leaves of the A. reticulata is used as a germicide and for the treatment of the skin diseases [27]. ...
Elemental concentrations namely P, S, Cl, K, Ca, Sc, Ti, Mn, Fe, Cu, Zn, Rb, Br and Sr were determined using Particle Induced X-ray Emission method in leaves and flowers of medicinal plants namely flowers of Hibiscus rosa-sinensis, leaves and flowers of Annona reticulata, leaves of holy basil and leaves of Psidium guajava. No toxic elements were detected in these samples. The method was validated by analyzing the reference materials namely IAEA RM V-10 and NIST SRM 1632a. The main objective of this study is to provide a good source of elemental concentration data for Ayurvedic medicine dosage.
... The fruit is a dry five-lobed capsule, containing several seeds in each lobe released when the capsule splits open at maturity. Some of the traditional medicinal uses, chemical composition, therapeutic evaluation of Hibiscus rosasinensis, has been carried out by Jadhav et al. (2009). H. rosa sinensis plant as a whole is used in various ailments from centuries. ...
... They are simple, effective, inexpensive, caffeine-, and drugfree ways to get taste and health benefits from herbs (Killedar & Pawar, 2017). reported to be rich in antioxidants and used as herbal teas (Jadhav, Thorat, Kadam, & Sathe, 2009;Naithani, Nair, & Kakkar, 2006). The combination of different plant-based foods might exhibit additive, synergistic, or antagonistic interactions, which in turn alter their biological activities (Gawlik-Dziki, 2012). ...
Meta‐analysis reports suggested that green tea (GT) consumption is associated with mild to moderate effects on major global killers. To enhance the health promoting potential of GT, one of the strategies is to combine it with traditionally used medicinal plants (Ocimum gratissimum, Cymbopogon citratus, Cymbopogon flexuosus, and Hibiscus rosa‐sinensis). The aim of this investigation was to evaluate and compare the possible synergistic antioxidant interaction of binary combinations of GT with medicinal plants. Overall, GT and O. gratissimum combination showed the highest antioxidant potential and strongest synergistic interaction at EC50. A strong correlation was found between antioxidant capacity (DPPH, ABTS, NO, and hemolysis) and total phenolic content (TPC) (except lipid peroxidation) for individual infusions, but very weak correlation was observed for GT combinations. Whereas, for both individual and binary aqueous infusions, moderate to strong correlation was observed between antioxidant parameters and FTIR‐selected peak (3250–3290 cm⁻¹) omitting lipid peroxidation for single infusions.
Practical applications
The combination of GT with certain medicinal plants used as herbal teas can demonstrate synergistic interactions that may boost the health promoting potential of GT. This study provides basis for future designing and formulation of beverages containing GT combinations based on their antioxidant interactions that can potentially enhance the efficacy of GT as a chemopreventive agent. It may also promote the consumption of GT combinations that may help in realizing untapped potential of underutilized plants.
... Plants produce secondary metabolites for their survival and acclimation (Zandalinas et al., 2017) as well as to perform its various functions (Stevenson et al., 2017), such chemical constituents are useful for human beings as it can help them to combat against different diseases (Jadhav et al., 2015). Such metabolites provides a good source of new drug in pharmaceutical research (Seca and Pinto, 2018). ...
The review focused on Ficus carica stem bark therapeutic importance as it is traditionally being used by people of rural areas as an anti-diabetic agent, anti-oxidant, anti-obesogenic, analgesic, anti-inflammatory, antipyretic, anti- bacterial, anti-fungal, anti-diarrheal, anti-cancer, anti-viral as well as used scientifically for the reduction of silver and gold nanoparticles (green nano-technology). Various research studies confirmed the presence of poly-phenolic compounds, flavonoids, cardiac glycoside, tannins, saponins, lipids and proteins in F. carica stem bark. Documented data available regarding the chemical constituents of F. carica stem bark are limited and there are only few known anti-microbial compounds previously isolated from. These chemicals compounds include ingenol, stigmasterol, campesterol, taraxerone, hexacosanate, hentriacontanol and euphorbol. The purpose of present paper is to assess the pharmacological and phytochemicals importance of Ficus carica stem bark.
... Cây dâm bụt (cây bụp) (Hibiscus rosa-sinensis L.) thuộc họ Bông Bụp (Malvaceae) với nhiều màu sắc khác nhau, được trồng phổ biến như là cây cảnh ở các nước nhiệt đới. Trong y học dân gian, hoa và lá dâm bụt được sử dụng như là chất kích thích sự mọc tóc, chữa lành vết loét và ung nhọt [7]. Theo y học cổ truyền, dược liệu này được gọi là xuyên can bì, có vị ngọt, tính bình, không độc, có tác dụng thanh nhiệt, lợi tiểu, giải độc và tiêu sưng. ...
Antibiotic resistance of bacterial strains causing serious diseases is one of the major concerns of public health worldwide. Metabolites of plants, particularly higher plants, have been suggested as alternative potential sources for antibacterial products due to their safe. They have little or no side effects and may act at multiple and novel target sites to bacteria. The study aims to evaluate antibacterial activities of leaf and flower extracts and solvent soluble fractions of the extracts against Proteus mirabilis, Pseudomonas aeruginosa, and Klebsiella pneumoniae, the major causes of infection-related kidney stones (struvite stones). Diameters of inhibitory zones, and MIC and MBC values of the extracts and fractions against the bacteria were evaluated. The results showed that the extracts and fractions derived from flowers have activities stronger than those from leaves, especially the ethyl acetate fraction (EtOAc fr.). The inhibitory zone diameters of 10 mg per paper disc of the EtOAC fr. towards Ps. aeruginosa, Pr. mirabilis, and K. pneumoniae were 17, 15 and 13 mm, respectively. The EtOAC fraction. had antibacterial activity against both Ps. aeruginosa and Pr. mirabilis with MIC (MBC) values of 2.5–5.0 (7.5) mg/mL and against K. pneumoniae with MIC (MBC) values of 7.5 (10) mg/mL. The fraction needs to be more studied for identifying its major active constituents. These leaf and flower extracts of H. rosa-sinensis could be used to treat against urinary tract infections caused by multiple drug resistant bacteria.
Endophytic fungi are defined as a population of micro-organisms which may present
themselves in the plant tissues without causing any apparent infection or disease symptoms to the host. These endophytes are found in almost all angiosperms. Hibiscus rosa-sinensis Linn. leaves have been used widely for their therapeutic uses as described in traditional medicine. It has various phyto-components that can confer properties such as anti-diabetic, antioxidant, and even anti-cancer. In the present study, H. rosa-sinensis Linn. leaves were used for isolating endophytic fungi. These isolated fungal organisms, after identification, were qualitatively
assessed for the production of enzymes such as amylase, protease, lipase and L-asparaginase. These enzymes have pharmaceutical and industrial significance. This study sheds valuable insight into the diversity of these microorganisms from Hibiscus rosa-sinensis L. which produces important host plant associated enzymes.
Abstarct The Hibiscus rosa sinensis is also known as Chinese rosa. The Hibiscus rosa sinesis plant are one of the most important sources of medicines. The medicinal plant are utilized the world in traditional system of medicine "Ayurveda". The Hibiscus rosa sinesis belong to the member of family of Malvaceae, and is one of the 300 species of the genus hibiscus. Rich source of the medicinal plant in India and is called "Botanical Garden of the World" with spacious wealth of biodiversity. In India recorded in 45,000 plant species so for of which 7,500species are used for medicinal purposes. Hibiscus rosa-sinensis are national flower of Malaysia. The genus of Hibiscus comprises about 275 species in the tropics and subtropics. It is found in China, India, and Malaysia etc. The Hibiscus rosa-sinensis are study in the various chemical constituent like: anthraquinones, phenols, alkaloids, terpenoids, cardiac glycoside, saponins, protein, flanoides, tannins, quinines, free amino acid, carbohydrate, mucilage, essential oil reducing sugar, and steroids. The plant of Hibiscus rosa sinensis are used in the various important pharmacological activity like: activity. The review summarizes the phytochemistry, pharmacology, and flower of uses with the purpose of finding gaps demanding for future investigation and research its therapeutic therapeutic through clinical trials.
BACKGROUND: The alteration of endogenous antioxidants and generation of reactive oxygen species induce hyperglycemia which may lead to the emergence of chronic problems in diabetes. The key enzymes responsible for hyperglycemia are α-amylase and α-glucosidase. Owing to the various negative consequences caused by synthetic medicines, there is a requirement for natural antioxidants and inhibitors for α-amylase, and α-glucosidase enzymes to attenuate hyperglycemia. This article entails the antioxidant potential as well as the inhibitory potential of the Hibiscus rosa-sinensis flower extracts in contrast to the enzymes involved in regulating hyperglycemia. METHODS: Flower extracts were prepared using solvents with ascending polarity viz. hexane, chloroform, ethyl acetate, n-butanol, methanol, and distilled water by maceration. Antioxidant capacity was investigated using 2,2-diphenyl-1-picrylhydrazyl free radical activity, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid cation(s) scavenging assay, ferric ion reducing-antioxidant power assay, and total antioxidant capacity. The inhibitory efficacy against α-amylase and α-glucosidase enzyme were investigated by performing α-amylase, and α-glucosidase inhibitory assays. To validate the observed results in in-vitro assays, the existence of polyphenolic compounds in the most potent extract was detected using ultra-high-performance liquid chromatography (UHPLC). Furthermore, in-silico analysis of the detected polyphenols in the most potent extract was done to understand the binding energies and docking at different sites of α-glucosidase and α-amylase enzymes, and it was contrasted to standard (acarbose). RESULTS: The most significant amount of antioxidant activity was noticed in the ethyl acetate extract in all the assays. Moreover, the ethyl acetate extract had a stronger suppressant effect on α-glucosidase and α-ainilase enzymes than other extracts and it was more in the case of α-glucosidase (IC50 value 53.33 µg/mL) as compared to α-amylase (IC50 value 83.02 µg/mL) enzymes There was a finding that among the polyphenolic compounds detected from the ethyl acetate extract via UHPLC, in which the docking studies were carried out, caffeic acid showed maximum binding energy with the α-glucosidase enzyme while epicatechin showed maximum binding energy with the α-amylase enzyme. CONCLUSIONS: The whole study concluded that caffeic acid and epicatechin have shown good interactions with concerned enzymes, and hence might contribute to the inhibition of hyperglycemic conditions and other diabetic problems caused by oxidative stress.
Background: The leaves and owers of Hibiscus rosa-sinensis have hair growth-promoting and anti-greying properties as well as excellent antimicrobial and antifungal activity. Active ingredients when added in shampoos which classify them as drugs. Medicated shampoos, in addition to cleansing and conditioning, deliver extra benets to the hair and scalp. Objectives:The objective of this study was to formulate a shampoo making use of the therapeutic activities of Hibiscus rosa-sinensis Linn. Methods: The study was carried out using standardized procedures at ST. WILFRED'S INSTITUTE OF PHARMACY, Panvel from 21 August 2021 to 21 December 2021. Our study included identication, quantitative analysis, extraction, pre-formulation studies, evaluation along with all other standard procedures required. Results: The alcoholic extracts of Hibiscus rosa-sinensis Linn. showed antimicrobial and antifungal activity. The formulated shampoo preparation passed all the recommended standard evaluation tests viz: Organoleptic properties, rheological evaluations, pH, percent solid test, foam producing, and foam retention capability, wetting time, surface tension, dirt dispersion, and cleansing action. Conclusion: The formulated shampoo revealed the ideal characteristics of the shampoo and is devoid of any harmful preservatives like paraben. It can be used as a safer alternative to its synthetic counterparts.
Hibiscus sheet mask is a natural skin care solution made from hibiscus flower (Hibiscus rosa-sinensis L.). The purpose of this study was to analyze the physical, chemical, and organoleptic of hibiscus sheet mask as an alternative to natural skin care. This study used a red and layered hibiscus flower crown. Extracts were made using the maceration method. The results of the flower extract are then made in various variations of mask formulas. The Hibiscus sheet mask was then analyzed by 10 panelists for its physical, chemical and organoleptic. The results showed that the higher the concentration of hibiscus flower extract, the more it produced a mask that was red in color, had a hibiscus aroma and a thick texture. The higher the concentration of hibiscus flower extract, the more the mask has a low pH. Meanwhile, the panelists prefer the hibiscus sheet mask with the 75% formula (F3). Thus, the hibiscus sheet mask can be accepted by the panelists.
Hibiscus rosasinensis and Butea monosperma have been traditionally claimed to be protective against liver injury. However, the hepatoprotective effect against iron overload is not yet validated scientifically. The present study was undertaken to evaluate the possible ameliorating effect of aqueous extract of Hibiscus rosasinensis (AQEHR) and Butea monosperma (AQEBM) against ferric nitrilotriacetate (Fe-NTA) induced hepatotoxicity in rats. After extraction, total phenolics and flavonoids content of AQEHR and AQEBM were estimated. Further, antioxidant effect followed by hepatoprotective efficacy of AQEHR and AQEBM were evaluated against chronic iron overload by administering Fe-NTA for 8 successive days to rats in increasing order of doses from 6-15mg Fe/kg. Treatments with both the extracts were started 3 days before the administration of iron and together with iron administration for 8 days. Level of liver function tests, triglycerides, protein, and lipid were recorded. Oxidative biomarkers and histopathology were performed to find out the level of protection by extracts. AQEBM contains a high amount of total phenolic and flavonoids contents and exhibited potent antioxidant effects in all assays. Supplementation of both the extract showed hepatoprotective effect by amelioration of biochemical changes and oxidative biomarkers. AQEBM possesses a higher amount of phenolic components and exhibited better therapeutic potential than AQEHR.
Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority of people living in underdeveloped countries. Medicinal plants have been used traditionally throughout the ages to treat various ailments due to their availability and safe nature. Medicinal plants are a rich source of phytochemicals that possess several health benefits. As diabetes continues to become prevalent, health care practitioners are considering plant-based medicines as a potential source of antidiabetic drugs due to their high potency and fewer side effects. To better understand the mechanism of action of medicinal plants, their active phytoconstituents are being isolated and investigated thoroughly. In this review article, we have focused on pharmacologically active phytomolecules isolated from medicinal plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes. These natural compounds may represent as good candidates for a novel therapeutic approach and/or effective and alternative therapies for diabetes.
Hibiscus sinensis is an annual/Perennial plant belongs to Malvaceae family commonly referred to as "roselle" famous for its medicinal value found world wide and native to West and East Africa, South-East Asia, Northeastern India. Roselle is cultivated in humid and warm climate. The plant consist phytoconstituents like malic, citric, tartaric, allo-hydroxycitric acid also reach in vitamin C, Vitamin A. Roselle is popular for it's therapeutic and nutritional value. Seeds, leaves, fruits and roots are utilized in herbal medicine for hair growth treatment. The Roselle, having various medically important compounds called photochemical, is documented for its nutritional and medicinal properties. Many parts of Roselle including seeds, leaves, fruits and roots are utilized in various foods also as in herbal medicine as a possible non-pharmacological treatment. In the treatment of various medical conditions, including several cardiovascular diseases, helmentic disease and cancer, different extracts from Roselle play an important role. Phytochemical research has reported that flavonoids, tannins, terpenoids, saponins, and alkaloids are the most bioactive compounds responsible for their medicinal effects. Experiments from recent studies have shown that different types of extracts from all Hibiscus. The components of rosa sinensis showed a good range of beneficial effects, such as hypotensive, anti-pyritic, anti-inflammatory, anti-cancer, antioxidant, anti-bacterial, anti-diabetic, wound healing, and abortifacient activities. Hibiscus rosa sinensis has been utilized in many herbal mix and drinks. This review plan to highlight the therapeutic application of Hibiscus rosa sinensis.
Background: The use of traditional medicine among people living with HIV/AIDS in Kisii County Kenya is high. There is need for more knowledge on how these therapies are concomitantly used with conventional antiretroviral therapy in the county.
Hibiscus rosa sinensis L. is one of medicinal plant and belongs to the family Malvaceae , Hibiscus species are used in the treatment of many disease, flowers are used to stimulate hair growth , wounds healing activity , anti-parasitic effect , Antidiabetic anti-hyperlipidemic activity. and have many pharmacological properties including anti-fertility , antipyretic, antispasmodic, , antifungal, anti-inflammatory and many more.
A pesticide is a substance used for controlling pests that damage the crops. Azadirachta indica (Neem) is widely studied and commercially used as a biopesticide against various pests. The present study aims to explore Momardica charantia (Bitter gourd) leaves as a biopesticide and compare its effectiveness with the Azadirachta indica (Neem) leaves and chemical pesticide (Admire). The test plant used for study is Hibiscus rosa-sinensis infected with Red Hibiscus mealy bug. Soil parameters (pH, conductivity, organic matter content, available potassium and available phosphorus) and plant characteristics (height, leaves count, flowering and chlorophyll content) of all test plants under study were estimated and compared. The soil parameter like pH showed no changes in control and treated plants while organic matter, available potassium and available phosphorus comparatively showed slight increase in concentration in plants treated with all pesticides. The plant characteristics viz. height, leaf count and branching showed improvement in growth after treatment with pesticides.All the pesticides under study were capable to kill mealy bugs in one month. Even though the biopesticidal property of Momardicacharantia leaves was found to be less as compared to Azadirachta indica leaves and chemical pesticide (Admire), it can be used effectively to control mealy bugs infecting Hibiscus plant.
The efficiency of the photovoltaic (PV) panel was queried in this research. Past research on spectra response has shown that the maximum solar response, i.e. using color filters is 24%. This result is not very good for a PV system exposed to the harsh weather condition in any part of the African continent. In this research, the bio-filter was used to perform spectral filtering of harmful solar radiation hitting the surface of the solar PV panel. The bio-filter was synthesized from the extract of the hibiscus flower. Hibiscus is a common plant found in almost all parts of Africa. The results show that the bio-filter has a relative efficiency of 94%. This makes the product a novel to be adopted in Africa and other tropical belts to elongate the life span and performance of the solar photovoltaic panel.
Ethnopharmacological relevance
The flowers of Hibiscus rosa sinensis has array of pharmacological actions. They are used in preparation of herbal decoction and teas, which have been used traditionally to reduce body weight and for its effect on metabolic syndrome.
Aim of the study
To investigate the anti adipogenic efficacy of major fraction from ethyl acetate extract of the Hibiscus rosa sinensis flower at 25 and 50 µg/mL (HRF 25 and 50 µg/mL) in 3T3-L1 cells and delineate its possible mechanism of action.
Materials and methods
Pre adipocyte 3T3-L1 cells were differentiated in the presence and absence of HRF 25 and 50 µg/mL, their lipid accumulation was measured qualitatively by Oil red O staining and quantitatively by triglyceride estimation. Effect on adipolysis was determined, adipogenic and its regulatory gene and protein expression were studied and effect of HRF 25 and 50 µg/mL on AMPK was confirmed in the presence of dorsomorphin.
Results
Treatment with HRF 25 and 50 µg/mL activated AMP-activated protein kinase (AMPK) and was found to alleviate triglyceride accumulation significantly (p < 0.001) by 1.6 and 2.3 times respectively in pre adipocytes during differentiation. HRF 25 and 50 µg/mL also nonsignificantly reduced lipolysis which releases free fatty acids, a major contributing factor for insulin resistance. Activation of AMPK by phosphorylation has led to reduced gene and protein expression of adipogenic factors Peroxisome proliferator- activated receptor gamma (PPAR-γ), CCAT/enhancer binding protein alpha (C/EBPα), Sterol regulatory element- binding protein-1c (SREBP-1c) and their targets Fatty acid binding protein 4 (FABP4), Fatty acid synthase (FAS), Perilipin and enhanced Adiponectin expression. Treatment with HRF 25 and 50 µg/mL also resulted in inactivation of Acetyl-CoA carboxylase (ACC) by enhancing ACC phosphorylation, which reduced the levels of malonyl-CoA an allosteric inhibitor of carnitine palmitoyl transferase 1 (CPT1). Enhanced CPT1 levels causes induction of fatty acid β- oxidation. Effects of HRF were nullified in the presence of AMPK antagonist dorsomorphin.
Conclusion
In summary, HRF treatments reduced adipogenesis, enhanced factors regulating fatty acid oxidation and this is mediated by AMPK activation. The results conclusively showed anti-obesity potential of HRF and it might be helpful in treatment of associated complications.
The modern day health care system in the Cook Islands is a combination of neo-traditional ways and Western medicine. The practice of "Maori medicine" is widespread in the Cook Islands, with native healers using a variety of herbal medicines and traditional practices to treat many of the common ailments affecting the people. After a historical review, the current methods of preparing and administering herbal medicines are discussed, followed by a discussion of what is commonly called "ghost sickness (maki tupapaku) in the islands. Included is a list of the 49 plants most commonly used in native cures, with information on how often and for what they are used. Also included is a glossary of Maori terms for the various ailments with which the healers are familiar.
Results are presented from a survey in which a sample of 887 people living in southern Ghana were questioned as to the chewing
sticks they use, reasons for choice, and whether sticks are collected or bought. It appears that four kinds of sticks account
for more than 85% of the total usage. Differences were recorded in preferred species and in diversity of species used, reason
for choice and source of supply, according to age, sex, ethnic origin, size of settlement and educational background.
In traditional Hawaiian society a wide variety of medicinal plants were used to promote the health and well-being of mothers and their offspring during pregnancy and childbirth. Some of these medicines are known to have therapeutic value and others may have unrecognized value. The scientific names for the botanical ingredients and recipes for some of the medicaments are provided. Medicinal plants were used for a variety of purposes. An expectant mother in addition to controlling her weight exercising and following food taboos was expected to ingest various substances in the belief that they would condition her body for birth and promote the health of the fetus. Pregnant women used other medicines as lubricants and laxatives. During birth the mother was given a medicinal liquid to drink between contractions in order to facilitate the delivery and this same liquid was used to lubricate the birth canal. After delivery the mother ingested a sap mixture to induce placenta expulsion a broth to expel blood and other potions to help her regain her strength and to cleanse the uterus. Medicaments were also used to promote healing of birth canal lacerations received during delivery. After birth the infant was oiled and powdered with plant materials and the mothers milk was used to cleanse the infants eyes. Additional plant medicines were used to stimulate lactation and still others to aid in conception.
Ethnobotanical data collection to select pharmacologically active species was carried out within a clearly defined therapeutic context: those plants used during the course of a woman's reproductive life. Extensive bibliographical and field data collection and cross-examination of the information thus gathered have provided us with a clearer picture of the effectiveness of these plant species. Various concepts, behaviours and practices relating to menstruation, pregnancy, birth and birth control were examined in detail from an ethnopharmacological point of view. A list of selected species of particular interest is proposed for further study.
Within Mexico's floristic abundance, plants with curative properties are outstanding due to their popularity in handling several illnesses, a fact that becomes specially important for the social groups of the tropical regions. In this paper the results of an ethnobotanical study carried out in 57 rural populations from the Mexican states of Oaxaca, Veracruz and Puebla are presented; questionnaire and interview methods were applied, with special attention to the use of plants for medical purposes. The most relevant results were: the taxonomic determination of 237 vegetal species from which 399 curative products are obtained, in order to combat 57 illnesses, the most frequent of which are those related to the digestive system, the skin, the reproductive system and those of supernatural origin, which can only be treated by the use of plants in special ceremonies known as 'limpias', due to their peculiar condition.
Traditional medicine has been practised in the South Pacific country of Fiji by almost all ethnic groups, both indigenous and immigrant. This paper reports on a survey on traditional medicinal practices in one major group, the Fiji Indians, who came from India in late 19th and early 20th century. The extent of knowledge and skills possessed by traditional healers and lay people, the plants and plant materials used by them for herbal remedies, parallel uses in India of the various plant species and their biodynamic properties are presented.
Various extracts of HIBISCUS ROSA-SINENSIS flowers have been studied for their antifertility activity on female albino rats. Benzene extract was found to be the most effective. For isolation of active constituents, the benzene extract was separated chemically into a number of fractions and their antifertility activities were studied systematically. The ether soluble portion of the water insoluble fraction of a benzene extract showed significant anti-implantation and abortifacient activities.
A representative mucilage, called Hibiscus-mucilage RL, was isolated from the leaves of Hibiscus rosa-sinensis L. It was homogeneous on electrophoresis, and its molecular mass was estimated to be roughly 1.0 x 10(7). Its intrinsic viscosity value in aqueous solution was 23.2. The major constituent is an acidic polysaccharide composed of L-rhamnose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 5:8:3:2. Methylation analysis, partial hydrolysis and nuclear magnetic resonance studies indicated its main structural features including a unique backbone chain composed of alpha-1,4-linked D-galactosyl alpha-1,2-linked L-rhamnosyl alpha-1,4-linked D-galacturonic acid units. The mucilage showed considerable anti-complementary activity.
PIP
A table of 76 selected species of plants which Indian medicine regards as having antifertility effects is presented. All the plants used for fertility control contain alkaloids, resins, tannins and bitter principles. The vulnerable points in the process of reproduction at which these plants act is not known.
PIP
The author collected folklore information on herbal treatments to control fertility from different parts of Assam, India. Temporary methods of birth control include Cissampelos pareira L. in combination with Piper nigrum L., root of Mimosa pudica L. and Hibiscus rosa-sinensis L. Plants used for permanent sterilization include Plumbago zeylanica L., Heliotropium indicum L., Salmalia malabrica, Hibiscus rosa-sinensis L., Plumeria rubra L., Bambusa rundinacea. Abortion is achieved through use of Osbeckia nepalensis or Carica papaya L. in combination with resin from Ferula narthex Boiss. It is concluded that there is tremendous scope for the collection of folklore about medicine, family planning agents, and other treatments from Assam and surrounding areas. Such a project requires proper understanding between the survey team and local people, tactful behavior, and a significant amount of time. Monetary rewards can also be helpful for obtaining information from potential respondents.
Petroleum ether extract of leaves and flowers of Hibiscus rosa-sinensis was evaluated for its potential on hair growth by in vivo and in vitro methods. In vivo, 1% extract of leaves and flowers in liquid paraffin was applied topically over the shaved skin of albino rats and monitored and assessed for 30 days. The length of hair and the different cyclic phases of hair follicles, like anagen and telogen phases, were determined at different time periods. In vitro, the hair follicles from albino rat neonates were isolated and cultured in DMEM supplemented with 0.01 mg/ml petroleum ether extract of leaves and flowers. From the study it is concluded that the leaf extract, when compared to flower extract, exhibits more potency on hair growth.