Article

Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami. Nat Nanotechnol 5:121-126

Department of Nanoengineering, 9500 Gilman Drive M/C 0448, University of California San Diego, La Jolla, California 92093-0448, USA.
Nature Nanotechnology (Impact Factor: 34.05). 12/2009; 5(2):121-6. DOI: 10.1038/nnano.2009.450
Source: PubMed

ABSTRACT

The development of nanoscale electronic and photonic devices will require a combination of the high throughput of lithographic patterning and the high resolution and chemical precision afforded by self-assembly. However, the incorporation of nanomaterials with dimensions of less than 10 nm into functional devices has been hindered by the disparity between their size and the 100 nm feature sizes that can be routinely generated by lithography. Biomolecules offer a bridge between the two size regimes, with sub-10 nm dimensions, synthetic flexibility and a capability for self-recognition. Here, we report the directed assembly of 5-nm gold particles into large-area, spatially ordered, two-dimensional arrays through the site-selective deposition of mesoscopic DNA origami onto lithographically patterned substrates and the precise binding of gold nanocrystals to each DNA structure. We show organization with registry both within an individual DNA template and between components on neighbouring DNA origami, expanding the generality of this method towards many types of patterns and sizes.

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Available from: Luisa D Bozano, Dec 19, 2014
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    • "Numerous practices have since been made including the preparation of ordered nanostructures [9], gene and drug delivery [10] and biosensing [11]. For instance, DNA has been used as a rigid spacer between Au nanoparticles to prepare ordered architectures with distance-dependent optical [12] and physical properties [13] [14] in terms of heat, electron, and energy transfer. In Ref. [12], the authors reported the preparation of highly uniform DNAtailorable Au nanoparticle architectures with 1 nm inter-particle gap. "
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    • "Various approaches have been taken to control the placement of DNA nanostructures on surfaces. Electron-beam and nanoimprint lithography have been used to pattern hydrophilic regions in a hydrophobic matrix (on the substrate surface) to which DNA origami could physisorb [15] [16] [17]. Other strategies rely on non-covalent interactions, such as ionic attractions on carboxyl-functionalized Au surfaces [18], or physisorption on nanopatterned, and chemically modified, graphene films [19]. "
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    • "In another major step toward wafer scale origami applications, DNA origamies have been placed and oriented on lithographically patterned surfaces thus combining the top-down and bottom-up approaches [61]. Furthermore, Hung et al. reported specific positioning of gold nanoparticles on top of lithographically confined DNA origamies [62]. Positioning and alignment of origami between nanoelectrodes has been demonstrated using dielectrophoretic trapping [63]. "
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