Article

A Comparative Analysis of Completed Suicide Using High Resolution Brain SPECT Imaging

Amen Clinic, Department of Research and Information Systems, 4019 Westerly Pl., Suite 110, Newport Beach, CA 92660, USA.
The Journal of Neuropsychiatry and Clinical Neurosciences (Impact Factor: 2.82). 10/2009; 21(4):430-9. DOI: 10.1176/appi.neuropsych.21.4.430
Source: PubMed

ABSTRACT

The authors compared regional cerebral blood flow in the brains of 12 psychiatric patients who completed the act of suicide with groups of healthy and nonsuicidal depressed subjects using statistical parametric mapping. Results were consistent with prior imaging studies on depression and were indicative of impaired impulse control and limbic dysregulation, including significant perfusion deficits in the medial prefrontal and subgenual areas (Brodmann's areas 11, 25) and ventral tegmentum. These results warrant further research.

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Available from: Daniel G. Amen, Jun 25, 2014
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    • "Neuroimaging studies have revealed reduced glucose metabolism in the prefrontal cortex in depressive patients with high-lethality suicide attempts compared to those with low-lethality attempts (Oquendo et al., 2003). Depression patients who completed suicide, compared with non-suicidal depression patients, had significantly higher regional cerebral blood flow (rCBF) in the right hemisphere (Amen et al., 2009). Consistent with this, Hunter and colleagues reported increased right prefrontal EEG coherence when patients with depression experienced worsening of suicidal ideation and mood symptoms during anti-depressant treatment (Hunter et al., 2010). "
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