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DOI: 10.7759/cureus.80171
A Rare Case of Spontaneous Healing of an
Anterior Cruciate Ligament Tear
Daniel R. Baka , Erastus Thuo , Veniamin Barshay , Dug Su Yun
1. Orthopaedics, Cooper University Hospital, Camden, USA 2. Radiology, Cooper University Hospital, Camden, USA 3.
Sports Medicine, Cooper University Hospital, Camden, USA
Corresponding author: Daniel R. Baka, dbaka1997@gmail.com
Abstract
Anterior cruciate ligament (ACL) injuries are among the most common knee injuries in the United States.
The ACL is an intra-articular ligament that resists anterior tibial translation and provides rotational
stability. Most ACL injuries occur through non-contact mechanisms and are typically diagnosed based on
history, physical examination, and confirmatory MRI. Treatment options include operative and non-
operative management, with the latter focusing on restoring functional stability rather than expecting the
ACL to heal spontaneously.
In this case report, we present a 33-year-old female patient with a sedentary lifestyle who experienced a
popping sensation and immediate swelling after twisting her knee while sitting down. She presented to the
clinic one week later, reporting knee instability and a dull, aching pain rated 7/10. Physical examination
revealed pain with passive knee extension and positive patellar compression, Clarke’s inhibition,
McMurray’s, and Lachman’s tests. MRI confirmed a complete ACL tear and a full-thickness cartilage defect
in the medial facet of the patella. The patient opted for non-operative treatment, including a crossover knee
brace and physical therapy. Over multiple follow-up visits, her range of motion and pain improved. Eleven
months post-injury, a follow-up MRI ordered to evaluate a suspected reinjury unexpectedly revealed a
completely intact ACL, indicating spontaneous healing.
This case highlights a rare instance of spontaneous ACL healing in a sedentary adult who chose conservative
management. Although non-operative therapy typically aims to restore function rather than facilitate
ligament healing, emerging evidence suggests spontaneous ACL healing is possible, particularly in proximal
femoral single-bundle tears. Further research is needed to establish standardized conservative treatment
protocols that optimize outcomes and promote ACL regeneration.
Categories: Orthopedics, Sports Medicine
Keywords: acl injuries, acl tear, anterior cruciate ligament (acl), conservative therapy, spontaneous healing
Introduction
Anterior cruciate ligament (ACL) injuries are among the most common knee injuries, with more than 200,000
cases occurring annually in the United States [1]. The ACL is an intra-articular ligament in the knee
composed of two distinct bundles: the anteromedial and posterolateral bundles [2,3]. Its primary function is
to restrain anterior translation of the tibia while also contributing to rotational stability [2,3]. Anatomically,
the ACL originates from the medial intercondylar notch of the lateral femoral condyle and attaches to the
tibial plateau [2,3]. It receives its blood supply primarily from the middle genicular artery, with additional
contributions from the inferomedial and inferolateral genicular arteries, and it is predominantly composed
of Type I collagen [2].
More than 40% of ACL injuries occur in non-contact scenarios [1]. High-risk movements include cutting and
planting, sudden changes in direction or speed, landing from a jump, twisting, and pivoting motions [4].
Clinical diagnosis typically relies on a detailed history and physical examination, with confirmation
provided by magnetic resonance imaging (MRI) [4]. Common physical exam tests used to assess ACL
integrity include the anterior drawer test, Lachman test, and pivot shift test [2,4].
Management of ACL injuries may be surgical or non-surgical, with treatment decisions based on patient
demographics, injury severity, and long-term functional goals [5]. Despite extensive research, there is no
definitive consensus on the superiority of one approach over the other, and treatment should be
individualized to optimize patient outcomes. With conservative therapy, the primary goal is to restore
functional stability rather than facilitate ligament healing [6]. Spontaneous ACL healing is not typically
expected and there have been no reported cases of spontaneous healing in non-athletic patients [6].
In this case report, we present the evaluation and management of a patient with a confirmed ACL tear on
MRI who opted for conservative treatment. Remarkably, follow-up imaging 11 months later revealed an
intact ACL, suggesting spontaneous healing.
1 1 2 3
Open Access Case Report
How to cite this article
Baka D R, Thuo E, Barshay V, et al. (March 06, 2025) A Rare Case of Spontaneous Healing of an Anterior Cruciate Ligament Tear. Cureus 17(3):
e80171. DOI 10.7759/cureus.80171
Case Presentation
A 33-year-old female presented to our clinic one week after sustaining a non-traumatic right knee injury.
The injury occurred while she was sitting and twisted her knee, hearing a popping sound followed by
swelling. She sought treatment at the emergency department (ED) the same day, where she was placed in a
knee immobilizer. At her initial clinic visit, she reported knee instability and episodes of the knee giving way.
She described her pain as a dull ache, rated 7/10, which worsened with prolonged walking but improved with
rest and analgesics.
On physical examination, there was mild effusion (+1) and tenderness over both the medial and lateral joint
lines. Her right knee range of motion (ROM) was 0-100° with pain on passive extension. Special tests were
positive for patella compression, Clarke’s inhibition, McMurray’s, and Lachman’s tests. X-rays obtained in
the ED showed no fractures or dislocations (Figures 1, 2). An MRI performed 10 days post-injury confirmed a
complete ACL tear along with a full-thickness defect in the articular cartilage of the medial facet of the
patella (Figures 3-5).
2025 Baka et al. Cureus 17(3): e80171. DOI 10.7759/cureus.80171 2 of 12
FIGURE 5: Axial T2 of the right knee showing a full-thickness fissure in
the medial patellar cartilage (yellow arrow)
Treatment options, including surgical and non-surgical management, were discussed with the patient.
Given her sedentary lifestyle, she opted for non-operative treatment but requested a consultation with a
surgeon for further evaluation. This consultation occurred one month post-injury, after which she decided to
continue with conservative management. She was referred for physical therapy, placed on work restrictions,
and fitted with a crossover hinged knee brace.
At her six-week follow-up, after two weeks of physical therapy, she reported no knee pain. Examination
revealed resolution of knee effusion and joint line tenderness. ROM improved to 0-120° without pain on
passive extension. Patella compression, Clarke’s inhibition, and Lachman’s tests remained positive, while
McMurray’s test was negative. She was cleared to return to work and continue physical therapy.
At her two-month follow-up, she had completed physical therapy and reported minimal pain, rating it 2/10.
Examination findings were unremarkable, with ROM unchanged. Patella compression, Clarke’s inhibition,
and Lachman’s tests remained positive. She was advised to continue home exercises and follow up as
needed.
At 7.5 months post-injury, she experienced a sudden popping sensation during knee extension, followed by
increased pain. She returned to the clinic at eight months post-injury with pain rated 5/10. Examination
revealed medial joint line tenderness but no significant changes in ROM. Patella compression and Clarke’s
inhibition tests remained positive, while Lachman’s test was negative. A cortisone injection was
administered, and a crossover knee brace was provided. She was advised to follow up in one month.
At her nine-month follow-up, she continued to report knee pain, still rated 5/10. Examination showed
tenderness along both the medial and lateral joint lines, but ROM remained stable. Patella compression,
Clarke’s inhibition, McMurray’s, and Lachman’s tests were positive. Given her worsening symptoms and the
prior popping sensation, there was concern for a possible meniscus injury, prompting an MRI.
At her 11-month follow-up, she continued to experience knee pain, rated 5/10. Examination findings
2025 Baka et al. Cureus 17(3): e80171. DOI 10.7759/cureus.80171 7 of 12
remained largely unchanged, with no knee instability, medial and lateral joint line tenderness, and stable
ROM (0-120°). Patella compression and Clarke’s inhibition tests were still positive, while Lachman’s test
remained negative. MRI, performed 10.4 months post-injury, unexpectedly revealed decreased signal
intensity compared to before, and an intact ACL with evidence of a healed tear, as well as a full-thickness
fissure in the articular cartilage of the medial patellar facet (Figures 6-8). She declined further cortisone
injections but was referred for continued physical therapy and prescribed diclofenac gel.
FIGURE 6: Sagittal proton density MRI of the right knee demonstrating
an intact ACL (yellow arrow)
ACL: anterior cruciate ligament
2025 Baka et al. Cureus 17(3): e80171. DOI 10.7759/cureus.80171 8 of 12
FIGURE 8: Axial T2-weighted MRI showing a full-thickness fissure in the
medial patellar cartilage (yellow arrow)
Discussion
We present a case of a 33-year-old female who experienced a "pop" and immediate knee swelling after
twisting her knee while attempting to sit on a public bus. ACL tears should be strongly suspected in patients
who report hearing a “pop” at the time of injury, particularly when accompanied by immediate swelling,
pain, and knee instability. Physical examination plays a critical role in diagnosis, with tests such as the
anterior drawer, Lachman, and lever tests being commonly used. While earlier studies reported 100%
sensitivity and specificity for the lever test, a more recent blinded cross-sectional study found the Lachman
and anterior drawer tests to be superior in specificity, with the Lachman test also demonstrating greater
sensitivity [7,8]. In this case, the patient had a positive Lachman test, raising high clinical suspicion, which
was later confirmed on MRI as a full-thickness ACL tear.
Following an ACL tear diagnosis, treatment decisions should involve shared decision-making, considering
injury severity, patient activity level, concomitant injuries, and long-term goals [9]. As noted in the
introduction, studies report minimal differences in outcomes between conservative therapy and surgical
reconstruction of the ACL. A meta-analysis found that while surgery resulted in less knee laxity, it was also
associated with a higher incidence of osteoarthritis, with no significant differences in patient-reported
outcomes [10].
The KANON study, which followed 121 young, active adults with acute ACL tears, compared structured
rehabilitation with early ACL reconstruction to structured rehabilitation with optional delayed surgery. Of
the latter group, 36 patients did not undergo surgery; however, after two years, there was no significant
difference in Knee Injury and Osteoarthritis Outcome Scores (KOOS) between the groups [11].
In this case, the patient had an isolated ACL tear and a sedentary lifestyle, making conservative therapy an
appropriate choice. When opting for non-operative management, the goal is to restore knee stability, as the
ACL itself is not expected to reattach [6]. Histological studies by Murray et al. suggest that the ACL has poor
healing capacity due to a lack of bridging tissue between torn segments. After an ACL tear, inflammatory
cells migrate to the injury site, followed by fibroblast proliferation and synovial sheath formation around the
2025 Baka et al. Cureus 17(3): e80171. DOI 10.7759/cureus.80171 10 of 12
distal ACL stump; however, reattachment typically does not occur [12].
Despite histological evidence suggesting poor healing capacity, Blanke et al. analyzed 381 ACL tears and
found that 14% healed spontaneously. Their findings suggest that femoral single-bundle lesions and
minimal posterior tibial slope increase the likelihood of healing [13]. Notably, our patient had a femoral
single-bundle lesion with a posterior tibial slope of 0-1°, aligning with these favorable parameters.
Other reports have described spontaneous ACL healing, though most are based on small case series, and no
reports have been published on spontaneous ACL healing in a middle-aged, sedentary female. Previ et al.
studied six recreational athletes with proximal third ACL tears treated with a knee extension brace for three
weeks, followed by at least two months of physiotherapy. MRIs at six months showed end-to-end ACL
continuity in all cases (Howell grades I and II) [14]. Costa-Paz et al. retrospectively examined 14 athletically
active patients with proximal third and mid-ligament complete ACL ruptures who underwent unspecified
physical therapy without bracing. At the final follow-up, all had an intact ACL and were able to return to
sports, though two patients experienced retears [15]. Our patient was instructed to use a cross-over brace
and attend physical therapy which could have aided in spontaneous ACL healing. However, there are no
direct guidelines on how to treat ACL tears conservatively to maximize healing, so it is uncertain the
influence therapy and bracing had on the healing potential.
Historically, the ACL was considered incapable of healing; however, these reports challenge that notion and
suggest the potential for spontaneous recovery in select cases [13-15]. Unfortunately, there are no
established guidelines for conservative treatment to optimize healing. Further research is needed to explore
the role of bracing, physiotherapy protocols, and other factors in promoting ACL regeneration.
Conclusions
This case highlights a rare instance of spontaneous ACL healing in a sedentary 33-year-old female who
opted for conservative management. After almost a year of conservative treatment, the patient reported that
she was back to her functional status before the injury and was not experiencing any knee instability;
however, she still had pain in her knee. While ACL tears can be treated surgically or non-surgically,
conservative therapy traditionally focuses on restoring function and stability rather than ligament
healing. However, emerging evidence suggests that spontaneous healing may occur, particularly in cases of
single-bundle proximal femoral tears. Additionally, patient activity level, biological variability, physical
therapy, and bracing may all influence healing potential. Currently, no standardized conservative treatment
protocols exist to optimize healing. Further research is needed to establish effective non-operative
strategies and develop guidelines to promote spontaneous ACL regeneration.
Additional Information
Author Contributions
All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the
work.
Concept and design: Daniel R. Baka, Dug Su Yun
Acquisition, analysis, or interpretation of data: Daniel R. Baka, Erastus Thuo, Veniamin Barshay, Dug
Su Yun
Drafting of the manuscript: Daniel R. Baka, Erastus Thuo
Critical review of the manuscript for important intellectual content: Daniel R. Baka, Erastus Thuo,
Veniamin Barshay, Dug Su Yun
Supervision: Dug Su Yun
Disclosures
Human subjects: Consent for treatment and open access publication was obtained or waived by all
participants in this study. Conf licts of interest: In compliance with the ICMJE uniform disclosure form, all
authors declare the following: Payment/services info: All authors have declared that no financial support
was received from any organization for the submitted work. Financial relationships: All authors have
declared that they have no financial relationships at present or within the previous three years with any
organizations that might have an interest in the submitted work. Other relationships: All authors have
declared that there are no other relationships or activities that could appear to have influenced the
submitted work.
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