No full-text available
To read the full-text of this research,
you can request a copy directly from the author.
Abstract
Background/Aim: With the availability of biosimilars, hospital formulary drug selection among biologics extends beyond clinical and safety considerations when comes to hospital resource management, to factors like human resource allocation and financial sustainability. However, research assessing the time and cost of labor, supplies, and waste disposal of biologics from the standpoint of hospitals remains limited. This study focuses on short-acting granulocyte-colony stimulating factor originators (Granocyte® and Neupogen®) and biosimilar (Nivestim®), comparing them based on mean total handling times per dose and total annual expenses. Materials and Methods: Ten nurses from a Taiwanese cancer center were recruited; they each prepared three doses of each drug. Results: Findings showed that the mean total handling times per dose of Granocyte® and Neupogen® were significantly higher than that of Nivestim®. Handling Nivestim® required the lowest total annual expense. Conclusion: Nivestim® is an advantageous alternative to Granocyte® and Neupogen®, benefiting hospital resource management.
ResearchGate has not been able to resolve any citations for this publication.
The transfer function and the transfer coefficient of a precision electromagnetoelastic engine for nanobiomedical research are obtained. The structural diagram of an electromagnetoelastic engine has a difference in the visibility of energy conversion from Cady and Mason electrical equivalent circuits of a piezo vibrator. The structural diagram of an electromagnetoelastic engine is founded. The structural diagram of the piezo engine for nanobiomedical research is written. The transfer functions of the piezo engine or are obtained.
A electroelastic engine with a longitudinal piezoeffect is widely used in nanotechnology for nanomanipulators, laser systems, nanopumps, and scanning microscopy. For these nanomechatronics systems, the transition between individual positions of the systems in the shortest possible time is relevant. It is relevant to solve the problem of optimizing the nanopositioning control system with a minimum control time. This work determines the optimal control of a multilayer electroelastic engine with a longitudinal piezoeffect and minimal control time for an optimal nanomechatronics system. The expressions of the control function and switching line are obtained with using the Pontryagin maximum principle for the optimal control system of the multilayer electroelastic engine at a longitudinal piezoeffect with an ordinary second-order differential equation of system. In this optimal nanomechatronics system, the control function takes only two values and changes once.
We obtained the condition absolute stability on the derivative for the control system of electromagnetoelastic actuator for communication equipment. We applied the frequency methods for Lyapunov stable control system to calculate the condition absolute stability control system of electromagnetoelastic actuator. We used Yakubovich criterion absolute stability system with the condition on the derivative. The aim of this work is to determine the condition of the absolute stability on the derivative for the control system of electromagnetoelastic actuator. We received the stationary set of the control system of the hysteresis deformation of the electromagnetoelastic actuator. The stationary set is the segment of the straight line.
In this work, the parametric structural schematic diagrams of a multilayer electromagnetoelastic actuator and a multilayer piezoactuator for nanomechanics were determined in contrast to the electrical equivalent circuits of a piezotransmitter and piezoreceiver, the vibration piezomotor. The decision matrix equation of the equivalent quadripole of the multilayer electromagnetoelastic actuator was used. The structural-parametric model, the parametric structural schematic diagram, and the matrix transfer function of the multilayer electromagnetoelastic actuator for nanomechanics were obtained.
The parametric block diagram of the electromagnetoelastic actuator nanodisplacement or the piezoactuator is determined in contrast the electrical equivalent circuit types Cady or Mason for the calculation of the piezoelectric transmitter and receiver, the vibration piezomotor with the mechanical parameters in form the velosity and the pressure. The method of mathematical physics is used. The parametric block diagram of electromagnetoelastic actuator is obtained with the mechanical parameters the displacement and the force. The transfer functions of the electroelastic actuator are determined. The the generalized parametric block diagram, the generalized matrix equation for the electromagnetoelastic actuator nanodisplacement are obtained. The deformations of the electroelastic actuator for the nanotechnology are described by the matrix equation. Block diagram and structural-parametric model of electromagnetoelastic actuator nanodisplacement for nanodisplacement of the communications systems are obtained, its transfer functions are bult. Effects of geometric and physical parameters of electromagnetoelastic actuators and external load on its dynamic characteristics are determined. For calculations the communications systems with the piezoactuator for nanodisplacement the parametric block diagram and the transfer functions of the piezoactuator are obtained.
The generalized parametric structural schematic diagram, the generalized structural-parametric model, and the generalized matrix transfer function of an electromagnetoelastic actuator with output parameters displacements are determined by solving the wave equation with the Laplace transform, using the equation of the electromagnetolasticity in the general form, the boundary conditions on the loaded working surfaces of the actuator, and the strains along the coordinate axes. The parametric structural schematic diagram and the transfer functions of the electromagnetoelastic actuator are obtained for the calculation of the control systems for the nanomechanics. The structural-parametric model of the piezoactuator for the transverse, longitudinal, and shift piezoelectric effects are constructed. The dynamic and static characteristics of the piezoactuator with output parameter displacement are obtained.
Last decade has seen growing research interest in vibration energy harvesting using piezoelectric materials. When developing piezoelectric energy harvesting systems, it is advantageous to establish certain analytical or numerical model to predict the system performance. In the last few years, researchers from mechanical engineering established distributed models for energy harvester but simplified the energy harvesting circuit in the analytical derivation. While, researchers from electrical engineering concerned the modeling of practical energy harvesting circuit but tended to simplify the structural and mechanical conditions. The challenges for accurate modeling of such electromechanical coupling systems remain when complicated mechanical conditions and practical energy harvesting circuit are considered in system design. In this article, the aforementioned problem is addressed by employing an equivalent circuit model, which bridges structural modeling and electrical simulation. First, the parameters in the equivalent circuit model are identified from theoretical analysis and finite element analysis for simple and complex structures, respectively. Subsequently, the equivalent circuit model considering multiple modes of the system is established and simulated in the SPICE software. Two validation examples are given to verify the accuracy of the proposed method, and one further example illustrates its capability of dealing with complicated structures and non-linear circuits.
The field of mechatronics using piezoelectric and electrostrictive materials is growing rapidly with applications in many areas, including MEMS, adaptive optics, and adaptive structures. Piezoelectric Actuators and Ultrasonic Motors provides in-depth coverage of the theoretical background of piezoelectric and electrostrictive actuators, practical materials, device designs, drive/control techniques, typical applications, and future trends in the field. Industry engineers and academic researchers in this field will find Piezoelectric Actuators and Ultrasonic Motors an invaluable source of pertinent scientific information, practical details, and references. In the classroom, this book may be used for graduate level courses on ceramic actuators.
Decision wave equation, structural - parametric model and block diagram of electro magneto elastic actuators are obtained, its transfer functions are bult. Effects of geometric and physical parameters of electro magneto elastic actuators and external load on its dynamic characteristics are determined. For calculation of communications systems with piezoactuators the block diagram and the transfer functions of piezoactuators are obtained.
Structural-parametric models, parametric structural schematic diagrams and transfer functions of electromagnetoelastic actuators are determined. A generalized parametric structural schematic diagram of the electromagnetoelastic actuator is constructed. Effects of geometric and physical parameters of actuators and external load on its dynamic characteristics are determined. For calculations the mechatronic systems with piezoactuators for nano- and microdisplacement the parametric structural schematic diagrams and the transfer functions of piezoactuators are obtained.
We received the structural circuit of the multilayer piezo engine for nanomedicine research. The characteristics of the multilayer piezo engine are obtained
The block diagram and the transfer functions of the electromagnetoelastic actuator are received for control systems in nanoscience and nanotechnology. The block diagram of the electromagnetoelastic actuator is reflected the transformation of electrical energy into mechanical energy, in contrast to Cady’s and Mason’s electrical equivalent circuits of piezotransducer. The electromagnetoelasticity equation and the second order linear ordinary differential equation with boundary conditions are solved for calculations the block diagram of the electromagnetoelastic actuator. The block diagram of the piezoactuator is obtained with using the reverse and direct piezoelectric effects. The back electromotive force is determined from the direct piezoelectric effect equation. The transfer functions of the piezoactuators are obtained for control systems in nanoscience and nanotechnology.
A generalized structural–parametric model of an electromagnetoelastic actuator is derived by solving the wave equation. Its transfer function is determined. The influence of geometric and physical parameters and the external load on its static and dynamic characteristics in the control system is established.
We developed a structural-parametric models, obtained solution for the wave equation of electroelastic actuators and constructed their transfer functions. Effects of geometric and physical parameters of electroelastic actuators and external loading on their dynamic characteristics determined. For calculation of automatic control systems for nanometric movements with electroelastic actuators, we obtained the parametric structural schematic diagrams and the transfer functions of piezoactuators. Static and dynamic characteristics of piezoactuators determined.
The use of nano- and micro-scale piezomotors in precision electromechanical systems is considered. The deformation of the piezoconverter corresponding to its stress state is investigated.
Based on the solution of a wave equation, a structural-parametric model of electromagnetoelastic converter for the electromechanical
drive of nano-and micrometric movements was constructed. A transformation was conducted for the structural-parametric model
and the parametric structural circuits. The influence of the geometric and physical parameters of this converter and of the
external load on the static and dynamical characteristics was estimated.
We design the static and dynamic characteristics of a piezoelectric nanomicrotransducer intended for use in nanotechnology
and microelectronic hardware, devise its parametric structural schematic diagram, and determine the influence of its physical
and geometric parameters on its static and dynamic characteristics.
The stability conditions for a system controlling the deformation of an electromagnetoelastic transducer under deterministic and random actions are discussed. Manufacturing high-precision electromechanical drives based on electromagnetoelasticity are offering challenges under the scope of nanotechnology, nanobiology, power engineering, microelectronics, and adaptive optics. High precision drives are operated within operating loads ensuring elastic strains of the executive electromagnetoelastic transducer. A system designed for the control of micro and nanoscale strains of an electromagnetoelastic transducer. The absolute stability conditions for a system with hysteresis nonlinearity are analytically described by using Yakubovic's absolute stability criterion. The absolute stability conditions obtained for a system can be used for stability estimation and the calculation of the characteristics of the control system.
The use of the solution to the wave equation to construct a generalized structural parametric model of an electromagnetoelastic transducer to determine the effect of its geometry and physical parameters is discussed. High-precision electromechanical drives are operated under working loads ensuring elastic strains of the executive device. Piezoelectric transducers are characterized by high piezoelectric moduli and they are frequently used to produce nanoscale displacements. The solution of the wave equation supplemented with the corresponding electromagnetoelasticity equation and boundary conditions on the transducer's two working surfaces allows to construct a structural parametric model of an electromagnetoelastic transducer. The transfer functions of a piezoelectric transducer are derived from its generalized structural parametric model and are obtained as the ratio of the Laplace transform of the transducer face displacement to the Laplace transform of the input electric parameter.
A study was conducted to prepare a structural parametric model of a pie piezoelectric nanodisplacement transducer. The structural parametric model was prepared to investigate the potential application of the piezoelectric transducer in the equipment of nanotechnology, microbiology, microelectronics, astronomy, for high-precision superposition, compensation, and wavefront correction. It was found that the piezoelectric transducer operates on the basis of the inverse piezoelectric effect, in which a displacement is due to the deformation of the piezoelectric element, caused by the application of an external electric voltage. The wave equations also needed to solved, to construct a structural parametric model of the voltage-controlled piezoelectric transducer.
The characteristics of the compound pawl and the compound central piezo converter of the step piezodrive are considered. The
influence of the geometric and physical parameters of the compound piezo converter and the external load on its static and
dynamical characteristics is determined. The transfer functions of the piezo converter as an electromechanical system with
distributed or lumped parameters are obtained. The static and dynamical characteristics of the step piezodrive are studied.
Calculation deformation of an engine for nano biomedical research
- S M Afonin
Afonin SM (2021). Calculation deformation of an engine for
nano biomedical research. International Journal of Biomed
Research 1(5): 1-4,
Solution wave equation and parametric structural schematic diagrams of electromagnetoelastic actuators nano-and microdisplacement
- S M Afonin
Afonin SM (2016). Solution wave equation and parametric
structural schematic diagrams of electromagnetoelastic actuators
nano-and microdisplacement. International Journal of
Mathematical Analysis and Applications 3(4): 31-38.
Multilayer engine for microsurgery and nano biomedicine
- S M Afonin
Afonin SM (2020). Multilayer engine for microsurgery and nano
biomedicine. Surgery & Case Studies Open Access Journal 4(4):
423-425,
Electroelastic digital-to-analog converter actuator nano and microdisplacement for nanotechnology
- S M Afonin
Afonin SM (2020). Electroelastic digital-to-analog converter
actuator nano and microdisplacement for nanotechnology.
Chapter 6 in Advances in Nanotechnology. Volume 24. Eds.
Bartul Z, Trenor J, Nova Science, New York, pp. 205-218.
Characteristics of an electroelastic actuator nano-and microdisplacement for nanotechnology
- S M Afonin
Afonin SM (2021). Characteristics of an electroelastic actuator
nano-and microdisplacement for nanotechnology. Chapter 8 in
Advances in Nanotechnology. Volume 25. Eds. Bartul Z, Trenor
J, Nova Science, New York, pp. 251-266,
Structural scheme of electroelastic actuator for nanomechatronics
- S M Afonin
Afonin SM (2020). Structural scheme of electroelastic actuator
for nanomechatronics, Chapter 40 in Advanced Materials.
Proceedings of the International Conference on "Physics and
Mechanics of New Materials and Their Applications",
PHENMA 2019. Eds: Parinov IA, Chang SH, Long BT.
Springer, Switzerland, Cham, pp. 487-502.
Absolute stability of control system for deformation of electromagnetoelastic actuator under random impacts in nanoresearch
- S M Afonin
- I A Parinov
- S H Chang
- Y H Kim
- N A Noda
- Springer
Afonin SM (2021). Absolute stability of control system for
deformation of electromagnetoelastic actuator under random
impacts in nanoresearch. Chapter 43 in Physics and Mechanics
of New Materials and Their Applications. PHENMA 2020.
Springer Proceedings in Materials. Volume 10. Eds. Parinov IA,
Chang SH, Kim YH, Noda NA. Springer, Switzerland, Cham,
pp. 519-531,